Affimer proteins inhibit immune complex binding to FcγRIIIa with high specificity through competitive and allosteric modes of action.
Robinson JI, Baxter EW, Owen RL, Thomsen M, Tomlinson DC, Waterhouse MP, Win SJ, Nettleship JE, Tiede C, Foster RJ, Owens RJ, Fishwick CWG, Harris SA, Goldman A, McPherson MJ, and Morgan AW.
Proceedings of the National Academy of Sciences 2017;115:E72-E81
Real-time characterization of antibody binding to receptors on living immune cells.
Bondza S, Foy E, Brooks J, Andersson K, Robinson J, Richalet P, and Buijs J.
Real-time characterization of antibody binding to receptors on living immune cells.
Bondza S, Foy E, Brooks J, Andersson K, Robinson J, Richalet P, and Buijs J.
Fc gamma RIIIa Expression on Monocytes in Rheumatoid Arthritis: Role in Immune-Complex Stimulated TNF Production and Non-Response to Methotrexate Therapy.
Cooper DL, Martin SG, Robinson JI, Mackie SL, Charles CJ, Nam J, Isaacs JD, Emery P, Morgan AW, and YEAR Consortium.
Confirmation of association of FCGR3B but not FCGR3A copy number with susceptibility to autoantibody positive rheumatoid arthritis.
Robinson JI, Carr IM, Cooper DL, Rashid LH, Martin SG, Emery P, Isaacs JD, Barton A, Wilson AG, Barrettt JH, Morgan AW, and BRAGGSS.
Dissection of the FCGR3A association with RA: increased association in men and with autoantibody positive disease.
Robinson JI, Barrett JH, Taylor JC, Naven M, Corscadden D, Barton A, Wilson AG, Emery P, Isaacs JD, Morgan AW, YEAR Consortium, and BRAGGSS.
Inferring relative proportions of DNA variants from sequencing electropherograms.
Carr IM, Robinson JI, Dimitriou R, Markham AF, Morgan AW, and Bonthron DT.
Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake.
Willcocks LC, Lyons PA, Clatworthy MR, Robinson JI, Yang W, Newland SA, Plagnol V, McGovern NN, Condliffe AM, Chilvers ER, Adu D, Jolly EC, Watts R, Lau YL, Morgan AW, Nash G, and Smith KGC.