Research

My research centers on elucidating the structural and molecular mechanisms driving experience-dependent synaptic remodeling in both health and disease. Specifically, I investigate how neurodevelopmental and neurological disorders—such as epilepsy, autism (ASD), and Alzheimer's disease—disrupt synaptic connectivity and reorganize the molecular architecture of the synapse.

To dissect these complex circuit-level and molecular alterations, I employ a multi-scale, integrative toolkit combining live confocal and high-throughput volume electron microscopy, molecular biology, biochemistry, computational modeling, and quantitative behavioral assays across genetic mouse models and human brain tissues.

Ultimately, my long-term goal is to bridge basic synaptic biology with translational medicine, providing structural and mechanistic insights that will lay the foundation for novel therapeutic strategies targeting synaptic dysfunction in conditions such as Alzheimer’s disease, autism, and epilepsy.