Research

The central objective of my research is to elucidate the structural and molecular mechanisms underlying experience-dependent synaptic remodeling in both physiological and pathological contexts. In particular, I study how brain disorders, including autism and epilepsy, alter synaptic connectivity and reshape the molecular composition of synapses. 

To address these questions, I employ a comprehensive array of neurobiological methodologies, including live confocal and volume electron microscopy, molecular and cellular biology, biochemistry, computational modeling, and behavioral analyses in genetic mouse models and human brain tissues. By integrating these approaches, my work aims to uncover how synaptic architecture adapts to normal experiences as well as pathological disruptions. 

In the long term, my goal is to advance our understanding of synaptic remodeling and contribute to the development of therapeutic strategies for synaptic dysfunctions associated with brain disorders such as Alzheimer’s disease, autism, and epilepsy.