Research
Brain MAP (painted by Lee KY)
Research Focus
The goal of my research is to understand structural and molecular mechanisms underlying experience-dependent synapse remodeling in physiological and pathological conditions. To investigate these issues, I have studied how activity modulation and/or brain disorders modify the pattern of synaptic connectivity and reorganize molecular composition of excitatory synapses in the brain.
I have utilized systematic neurobiological approaches including 3D electron microscopy and live imaging, molecular cell biology, biochemistry, and behavioral tests with rodent models. In long-term perspective, I hope to provide key insights into neuronal circuit plasticity as well as therapeutic regimens for synaptic impairments involved in brain disorders such as Alzheimer's disease, autism and epilepsy.
Research Area I
Reconstruction of Neural Circuits using 3D Electron Microscopy
3차원 전자현미경 기반 시냅스 및 세포소기관 구조 분석
뇌질환동물모델(또는 환자 샘플)의 신경회로 구조변화 규명
Research Area II
Functional Role for Synaptic Proteins in health and disease
시냅스 단백질의 기능 규명 연구 (분자신호전달기전연구)
학습/뇌질환 시 변화하는 시냅스 단백질의 기능적 역할 규명
3D reconstruction of a Pyramidal neuron and a PV+ interneuron
We are hiring, come join us!
Undergraduate student researcher
Graduate student researcher
Postdoctoral Fellow
If interested, send an email (including CV and Research statement) to relaylee@kbri.re.kr.