Publications

Papers

1. Park C, Gim J, Bahn S, Kim GH, Im Y, Lee SH, Lee K, Kim MS, Lee KJ†, Kim JS†. A cerebellar disinhibitory circuit supports synaptic plasticity. bioRxiv,  doi: https://doi.org/10.1101/2023.09.15.557147, 2023. †Co-correspondence.

2. Lee S, Jo M, Kwon Y, Jeon YM, Kim S, Lee KJ, Kim HJ. PTK2 regulates tau-induced neurotoxicity via phosphorylation of p62 at Ser403. J Neurogenet, 37(1-2):10-19,  2023.

3. Iwasaki H, Lee KJ. Editorial: Cutting-edge technology for the comprehensive analysis of neural circuits. Front Neuroanat, 16:1101560, 2022.

4. Park C, Gim J, Lee S, Lee KJ, Kim JS. Automated synapse detection method for cerebellar connectomics. Front Neuroanat, 16:760279, 2022. 

5. Kim J*, Park D*, Seo NY*, Yoon TH*, Kim GH, Lee SH, Seo J, Um JW, Lee KJ†, Ko J†. LRRTM3 regulates activity-dependent synchronization of excitatory synapse properties in topographically connected hippocampal neural circuits. PNAS USA, 119(3): e2110196119, 2022. *Equal contribution, †Co-correspondence.

6. Kim D, Jung H, Shirai Y, Kim H, Kim J, Lim D, Mori T, Lee H, Park D, Kim HY, Guo Q, Pang B, Qiu W, Cao X, Kouyama-Suzuki E, Uemura T, Kasem E, Fu Y, Kim S, Tokunaga A, Yoshizawa T, Suzuki T, Sakagami H, Lee KJ, Ko J, Tabuchi K, Um JW.  IQSEC3 deletion impairs fear memory through upregulation of ribosomal S6 kinase 1 signaling in the hippocampus. Biol Psychiatry, 91(9):821-831, 2022.

7. Jang YN, Jang H, Kim GH, Noh JE, Chang KA, Lee KJ. RAPGEF2 mediates oligomeric Aβ-induced synaptic loss and cognitive dysfunction in the 3xTg-AD mouse model of Alzheimer's disease. Neuropathol Appl Neurobiol, 47(5): 625-639, 2021.

8. Seo NY*, Kim GH*, Noh JE, Shin JW, Lee CH, Lee KJ. Selective Regional Loss of Cortical Synapses Lacking Presynaptic Mitochondria in the 5xFAD Mouse Model. Front Neuroanat, 15: 690168, 2021. *equal contribution.

9. Kim GH,  Zhang Y, Kang HR, Lee SH, Shin J, Lee CH, Kang H, Ma R, Jin C, Kim Y, Kim SY, Kwon SK, Choi SY†, Lee KJ†, Han K†. Altered presynaptic function and number of mitochondria in the medial prefrontal cortex of adult Cyfip2 heterozygous mice. Mol Brain, 13(1): 123, 2020. †co-correspondence. 

10. Kim JY, Park S, Park SH, Lee D, Kim GH, Noh JE, Lee KJ, Kim GJ. Overexpression of pigment epithelium-derived factor in placenta-derived mesenchymal stem cells promotes mitochondrial biogenesis in retinal cells. Lab Invest, 101(1): 51-69, 2020.

11. Lee SH, Zhang Y, Park J, Kim B, Kim Y, Lee SH, Kim GH, Huh YH, Lee CH, Do NY, Lee B, Kim Y, Lee Y, Kim JY, Kang H, Choi SY, Jang S, Li Y, Kim S, Jin C, Pang K, Kim E, Lee Y, Kim H, Kim E, Choi JH, Kim J, Lee KJ†, Choi SY†, Han K†. Haploinsufficiency of Cyfip2 causes Lithium-responsive prefrontal dysfunction. Ann Neurol, 88(3): 526-543, 2020. †co-correspondence.

12. Xu Z, Kim GH, Tan J, Riso A, Sun Y, Lee S, Liao G, Do NY, Lee CH, Cipperton-Allen A, Kwon S, Page D, Lee KJ, Xu B. Elevated protein synthesis causes autism-like synaptic and behavioral aberrations through microglia. Nat Commun, 11(1): 1797, 2020.

13. Kim Y, Jang YN, Kim JY, Kim N, Noh S, Kim H, Queenan BN, Bellmore R, Mun JY, Park H, Rah JC, Pak DTS, Lee KJ. Microtubule-associated protein 2 mediates induction of long-term potentiation in hippocampal neurons. Faseb J, 34(5): 6965-6983, 2020.

14. Jeon MT, Moon GJ, Kim S, Choi M, Oh YS, Kim DW, Kim HJ, Lee KJ, Choe Y, Ha CM, Jang IS, Nakamura M, McLean C, Chung WS, Shin WH, Lee SG, Kim SR. Neurotrophic interactions between neurons and astrocytes following AAV1-Rheb(S16H) transduction in the hippocampus in vivo. Br J Pharmacol, 177(3): 668-686, 2020.

15. Lee S, Jeon YM, Cha SJ, Kim S, Kwon Y, Jo M, Jang YN, Lee S, Kim J, Kim SR, Lee KJ, Lee SB, Kim K, Kim HJ. PTK2/FAK regulates UPS impairment via SQSTM1/p62 phosphorylation in TARDBP/TDP-43 proteinopathies. Autophagy, 16(8): 1396-1412, 2020.

16. Moon GJ, Kim S, Jeon MT, Lee KJ, Jang IS, Nakamura M, Kim SR, Therapeutic Potential of AAV1-Rheb(S16H) Transduction Against Alzheimer’s Disease. J Clin Med, 8(12): 2053, 2019.

17. Jang HC, Ryu JH, Shin KM, Seo N, Kim GH, Huh YH, Pae AN, Lee KJ. Gait ignition failure in JNPL3 human tau-mutant mice. Exp Neurobiol, 28(3): 404-413, 2019.

18. Lee JS, Lee Y, André E, Lee KJ, Nguyen T, Feng Y, Jia N, Harris B, Burns M, Pak DTS. Inhibition of Polo-like kinase 2 ameliorates pathogenesis in Alzheimer’s disease model mice. PLOS One, 14(7): e0219691, 2019.

19. Kim HW, Oh S, Lee SH, Lee S, Na JE, Lee KJ*, Rhyu IJ*. Different types of multiple-synapse boutons in the cerebellar cortex between physically enriched and ataxic mutant mice. Microsc Res Tech, 82(1): 25-32, 2019. *co-correspondence.

20. Leem E, Kim HJ, Choi M, Kim S, Oh YS, Lee KJ, Choe YS, Um JY, Shin WH, Jeong JY, Jin BK, Kim DW, McLean C, Fisher PB, Kholodilov N, Ahn KS, Lee JM, Jung UJ, Lee SG, Kim SR. Upregulation of neuronal astrocyte elevated gene-1 protects nigral dopaminergic neurons in vivo. Cell Death Dis, 9(5): 449, 2018.

21. Park SK, Ko SJ, Paik SK, Rah JC, Lee KJ, Bae YC. Vesicular glutamate transporter 1 (VGLUT1)- and VGLUT2-immunopositive axon terminals on the rat jaw-closing and jaw-opening motoneurons. Brain Struct Funct, 223(5): 2323-2334, 2018.

22. Hong M, Ryu L, Ow MC, Kim J, Je AR, Chinta S, Huh YH, Lee KJ, Butcher RA, Choi H, Sengupta P, Hall SE, Kim K. Early Pheromone Experience Modifies a Synaptic Activity to Influence Adult Pheromone Responses of C. elegans. Curr Biol, 27(20): 3168-3177, 2017.

23. Lee Y, Lee JS, Lee KJ, Turner RS, Hoe HS, Pak DT. Polo-like kinase 2 phosphorylation of amyloid precursor protein regulates activity-dependent amyloidogenic processing. Neuropharmacology, 117: 387-400, 2017.

24. Kim GH, Gim JW, Lee KJ. Nano-Resolution Connectomics Using Large-Volume Electron Microscopy. Appl Microsc, 46(4): 171-175, 2016.

25. Jeong SJ, Lee H, Hur EM, Choe Y, Koo JW, Rah JC, Lee KJ, Lim HH, Sun W, Moon C, Kim K. Korea Brain Initiative: Integration and Control of Brain Functions. Neuron, 92(3): 607-611, 2016.

26. Sun AX, Yuan Q, Tan S, Xiao Y, Wang D, Khoo AT, Sani L, Tran HD, Kim P, Chiew YS, Lee KJ, Yen YC, Ng HH, Lim B, Je HS. Direct Induction and Functional Maturation of Forebrain GABAergic Neurons from Human Pluripotent Stem Cells. Cell Rep, 16(7): 1942-1953, 2016.

27. Kim KH*, Lee SH*, Lee KJ. Reconstruction of neural circuits using serial block-face scanning electron microscopy. Appl Microsc, 46(2): 100-104, 2016. *equal contribution.

28. Queenan BN, Lee KJ, Tan H, Huganir RL, Vicini S, Pak DT. Mapping homeostatic synaptic plasticity using cable properties of dendrites. Neuroscience, 315: 206-216, 2016.

29. Kim JA, Ha S, Shin KY, Kim S, Lee KJ, Chong YH, Chang KA, Suh YH. Neural stem cell transplantation at critical period improves learning & memory through restoring synaptic impairment in Alzheimer's disease mouse model. Cell Death Dis, 6: e1789, 2015.

30. Lee KJ, Rhyu IJ, Pak DT. Synapses need coordination to learn motor skills. Rev Neurosci, 25(2): 223-230, 2014.

31. Lee KJ, Park IS, Kim H, Pak DT, Greenough WT, Rhyu IJ. Motor skill training induces coordinated strengthening and weakening between neighboring synapses. J Neurosci, 33(23): 9794-9799, 2013.

32. Lee KJ*, Queenan BN*, Rozeboom AM, Bellmore R, Lim ST, Vicini S, Pak DT. Mossy fiber-CA3 synapses mediate homeostatic plasticity in mature hippocampal neurons. Neuron, 77(1): 99-114, 2013. *equal contribution.

33. Queenan BN, Lee KJ, Pak DT. Wherefore art thou, Homeo(stasis)? Functional diversity in homeostatic synaptic plasticity. Neural Plasticity, 2012: 718203, 2012.

34. Lee KJ, Hoe HS, Pak DT. Plk2 Raps up Ras to subdue synapses. Small GTPases, 2(3): 162-166, 2011.

35. Lee KJ, Lee Y, Rozeboom A, Lee JY, Udagawa N, Hoe HS, Pak DT. Requirement for Plk2 in orchestrated Ras and Rap signaling, homeostatic structural plasticity, and memory. Neuron, 69(5): 957-973, 2011.

36. Lee KJ, Moussa CE, Lee Y, Sung Y, Howell BW, Turner RS, Pak DT, Hoe H. Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines. Neuroscience, 169(1): 344-356, 2010.

37. Oda SI, Lee KJ, Arii T, Imoto K, Hyun BH, Park IS, Kim H, Rhyu IJ. Differential regulation of Purkinje cell dendritic spines in rolling mouse Nagoya, P/Q type calcium channel (a1(A)/Ca(v)2.1) mutant. Anat Cell Biol, 43(3): 211-217, 2010.

38. Park IS, Lee KJ, Han JW, Lee NJ, Lee WT, Park KA, Rhyu IJ. Basketball training increases striatum volume. Hum Mov Sci, 30(1): 56-62, 2010.

39. Grossman AW, Aldridge GM, Lee KJ, Zeman MK, Jun CS, Azam HS, Arii T, Imoto K, Greenough WT, Rhyu IJ. Developmental characteristics of dendritic spines in the dentate gyrus of Fmr1 knockout mice. Brain Res, 1355: 221-227, 2010.

40. Rhyu IJ, Bytheway J, Kohler SJ, Lange H, Lee KJ, Boklewski J, McCormick K, Williams NI, Stanton GB, Greenough WT, Cameron JL. Effects of aerobic exercise training on cognitive function and cortical vascularity in monkeys. Neuroscience, 167(4): 1239-1248, 2010.

41. Hoe H*, Lee KJ*, Carney R, Lee J, Makarova A, Lee JY, Howell B, Hyman B, Pak D, Bu G, Rebeck GW. Interaction of Reelin with APP promotes neurite outgrowth. J Neurosci, 29(23): 7459-7473, 2009. *equal contribution.

42. Lee KJ and Rhyu IJ. Effects of exercise on structural and functional changes in the aging brain. J Korean Med Assoc, 52(9): 907-919, 2009.

43. Kim WR, Park OH, Choi S, Choi SY, Park SK, Lee KJ, Rhyu IJ, Kim H, Lee YK, Kim HT, Oppenheim RW, Sun W. The maintenance of specific aspects of neuronal function and behavior is dependent on programmed cell death of adult-generated neurons in the dentate gyrus. Eur J Neurosci, 29: 1408-1421, 2009.

44. Park IS, LEE KJ, Han JW, LEE NJ, LEE WT, Park KA, Rhyu IJ. Experience-dependent plasticity of cerebellar vermis in basketball players. Cerebellum, 8(3): 334-339, 2009.

45. Lee KJ, Jung JG, Arii T, Imoto K, Rhyu IJ. Morphological changes in dendritic spines of Purkinje cells associated with motor learning. Neurobiol Learn Mem, 88(4): 445-450, 2007.

46. Park OH, Lee KJ, Rhyu IJ, Geum D, Kim H, Buss R, Oppenheim RW, Sun W. Bax-dependent and -independent death of motoneurons after facial nerve injury in adult mice. Eur J Neurosci, 26: 1421-1432, 2007.

47. Lee KJ and Rhyu IJ. Estimation of number of synapses on a neuron in the brain using physical disector method. Korean J Electron Microsc, 36: 83-91, 2006.

48. Park IS, Han JW, Lee KJ, Lee NJ, Lee WT, Park KA, Rhyu IJ. Evaluation of morphological plasticity in the cerebella of basketball players with MRI. J Korean Med Sci, 21(2): 342-346, 2006.

49. Lee KJ, Park C, Rhyu IJ. Efficient three-dimensional reconstruction of synapse with high-voltage electron microscopy. J Electron Microsc, 54(2): 139-141, 2005.

50. Lee KJ, Kim H, Rhyu IJ. The roles of dendritic spine shapes in Purkinje cells. Cerebellum, 4: 97-104, 2005.

51. Lee KJ, Kweon H, Kang JS, Rhyu IJ. 3-dimensional reconstruction of parallel fiber-Purkinje cell synapses using high-voltage electron microscopy. Korean J Electron Microsc, 35(1): 31-39, 2005.

52. Lee KJ, Kim H, Kim TS, Park SH, Rhyu IJ. Morphological analysis of spine shapes of Purkinje cell dendrites in the rat cerebellum using high-voltage electron microscopy. Neurosci lett, 359(1-2): 21- 24, 2004.

53. Kim HT, Kim IH, Lee KJ, Lee JR, Park SK, Chun Y, Kim H, Rhyu IJ. Specific plasticity of parallel fiber/Purkinje cell spine synapses by motor skill learning. Neuroreport, 13(13): 1607-1610, 2003.

54. Rhyu IJ, Lee KJ, Seo YS. Observation of Purkinje cell dendritic spines using high voltage electron microscopy. Korean J Electron Microsc, 31: 1-8, 2001.

Patent

1. 뇌의 내측 전전두피질에서의 아밀로이드 침착수준 및 미토콘드리아 결핍 시냅스 분석을 통한 알츠하이머병의 조기 진단방법 (10-2021-0116826), 기여율 70%, 2021.09.02.