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4-VA funded collaborative research
4-VA funded collaborative research
From July 2024 -- June 2025, I led a team including immunologists (L. Muehling and G. Canderan, UVA), a graduate student (K. Ellis), and undergraduate students (J. O'Hanlon, K. Sullivan) on a project entitled "Data-Driven Modeling of the Time-Dependent Immune Response to Infection and Vaccination." The project was funded by a collaborative research grant from 4-VA, a collaborative partnership for advancing the Commonwealth of Virginia.Â
Probabilistic models of antibody response by biological sex. Models indicate the probability of observing an antibody measurement; a standard time of 120 days between infection and vaccination is used for visualization. Black lines show model contours; blue lines connect an individual's measurements.
Our work culminated in a student-led, peer-reviewed paper published in Spora: A Journal of Biomathematics. The models suggest strong dissimilarities between male and female antibody responses and replicated the elevated cytokine response seen in those with pulmonary symptoms post-acute infection.
Sightseeing at Monticello after a visit to UVA. L-R: R. Luke, K. Ellis, L. Muehling, G. Canderan, K. Sullivan, J. O'Hanlon
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