Publications

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Selected Publications

Shirafkan F, Hensel L, Rattay K. Immune tolerance and the prevention of autoimmune diseases essentially depend on thymic tissue homeostasis. Frontiers in Immunology. 2024.
https://doi.org/10.3389/fimmu.2024.1339714

Lammers S, Barrera V, Brennecke P, Miller C, Yoon J, Balolong J, Anderson MS, Ho Sui S, Steinmetz LM, von Andrian UH, Rattay K. Ehf and Fezf2 regulate late medullary thymic epithelial cell and thymic tuft cell development. Frontiers in Immunology. 2024. 

https://doi.org/10.3389/fimmu.2023.1277365 

Sundaresan B, Shirafkan F, Ripperger K, Rattay K. The Role of Viral Infections in the Onset of Autoimmune Diseases. Viruses. 2023.

https://doi.org/10.3390/v15030782 

Vollmann EH, Rattay K, Barreiro O, Thiriot A, Fuhlbrigge RA, Vrbanac V, Kim KW, Jung S, Tager AM, von Andrian UH. Specialized transendothelial dendritic cells mediate thymic T-cell selection against blood-borne macromolecules. Nature Communications. 2021.

https://doi.org/10.1038/s41467-021-26446-x 

Miller CN, Proekt I, von Moltke J, Wells KL, Rajpurkar AR, Wang H, Rattay K, Khan IS, Metzger TC, Pollack JL, et al. Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development. Nature. 2018.

https://doi.org/10.1038/s41586-018-0345-2 

Rattay K, Meyer HV, Herrmann C, Brors B, Kyewski B. Evolutionary conserved gene co-expression drives generation of self-antigen diversity in medullary thymic epithelial cells. Journal of Autoimmunity. 2016.

https://doi.org/10.1016/j.jaut.2015.10.001 

Brennecke P, Reyes A, Pinto S, Rattay K, Nguyen M, Kuchler R, et al. Single-cell transcriptome analysis reveals coordinated ectopic gene-expression patterns in medullary thymic epithelial cells. Nature Immunology. 2015.

https://doi.org/10.1038/ni.3246 

Ucar O, Rattay K. Promiscuous Gene Expression in the Thymus: A Matter of Epigenetics, miRNA, and More. Frontiers in Immunology. 2015.

https://doi.org/10.3389/fimmu.2015.00093 

Rattay K, Claude J, Rezavandy E, Matt S, Hofmann TG, Kyewski B, Derbinski J. Homeodomain-interacting protein kinase 2, a novel autoimmune regulator interaction partner, modulates promiscuous gene expression in medullary thymic epithelial cells. Journal of Immunology. 2015.

https://doi.org/10.4049/jimmunol.1402694