Rattay Lab

Welcome to the Rattay Lab

The Rattay Lab investigates the cellular and molecular mechanisms that establish central immune tolerance and prevent autoimmune disease. We focus on thymic development, tissue homeostasis, and the complex interactions between lymphocytes and stromal cell populations. 

Our research combines genomics, imaging, and advanced 3D culture systems to understand how the thymus shapes T-cell development across health and disease.

Research areas

• Thymic development and tissue homeostasis
  
  

• Cell-cell communication within the thymus
  
  

• Mechanisms of antigen presentation and selection
  
  

• Regulation of thymic epithelial cell heterogeneity
  
  

• Central tolerance and autoimmunity

Our approach

We use single-cell and bulk RNA-sequencing, ATAC-seq, ChIP-seq, confocal and high-resolution imaging, computational biology, and functional assays to dissect key processes driving immune tolerance.

Learn more about our research

Location

The lab is part of the Institute of Experimental and Clinical Pharmacology at Kiel University and the University Hospital Schleswig-Holstein

Rattay Lab

Institute of Experimental and Clinical Pharmacology

Medical Faculty, Kiel University

University Hospital Schleswig-Holstein (UKSH)