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My primary research interest lies in Bioinorganic Chemistry, with a particular focus on advancing the development of Hypoxia-Activated Pro-drugs (HAP) for the purpose of combatting cancer. My academic and research journey has led me to specialize in three key areas, reflective of my doctoral and postdoctoral research
Tumor imaging with Ru-compounds
Tumor imaging with Ru-compounds
Does the metal complexes penetrate the solid tumors? after the successful entry of cisplatin as anti cancer drug. metal complexes has been in surge for search of novel anti-cancer agents. However, it is not clear whether the orther metals like Ru- can penetrate the solid tumors. The famous light-switch complex [Ru(bpy2)(dppz)]2+ (1) has been investigate as cellular imaging probe in 2D monolayer cells and 3D tumor spheroids of various cell line. This light-switch complex found to displace the classical DNA staining dye Hoechst in the 2D mono layer cells as well as 3D tumor spheroids.
Two-Photon induce CO-releasing molecules
Development of Photo-Induced Carbon Monoxide Releasing Molecules (PhotoCORMs) for Anti-Inflammatory Applications. I have dedicated significant efforts to creating innovative compounds capable of releasing carbon monoxide upon exposure to light, with potential applications in mitigating inflammation.
Cytostatic Ru(II)–Pt(II) Bis(terpyridyl) complex synthesis
Cytostatic agents that interfere with specific cellular components to prevent cancer cell growth offer an attractive alternative, or complement, to traditional cytotoxic chemotherapy. I have ample experience in design, synthesis of bimetallic complexes and study their cytostatic behavior in cancer cells to fight cancer.
Metal complexes for sensing tumor hypoxia
Design of Self-Referenced Metal Complexes for O2/pH Sensing in Cancer Cells. My work extends to the development of advanced metal complexes engineered for precise oxygen and pH sensing within cancer cells, employing state-of-the-art Resonance Raman spectroscopy techniques.
Photo activated Chemotherpy
Photodynamic therapy (PDT) is a clinical approach combating cancer by utilizing photosensitizers that concentrate in cancerous tissues. These sensitizers are activated by illuminating the tumor with visible light. An innovative concept, Photoactivated chemotherapy (PACT), merges these principles. Similar to PDT, PACT strives to spare healthy tissues while effectively targeting cancer cells
Ru-Based Coordination Polymer Nanoparticles
Photoactive Ru-based coordination polymer nanoparticles (CPNs), synthesis and cytotoxicity studies in various cancers cells.
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