Publications

List of Journal Publications

15. Breaking the one-site myth: the multifaceted world of proton sensing in GPCRs. Agrawal M, Singh, SK, Baidya M* and Kumari P*. FEBS Journal (2025). pp1-14.

14. Exploring Bias in GPCR Signaling and its Implication in Drug Development: A One-Sided Affair. Borah MP, Trakroo D, Kumari P*, Baidya M* Biochemistry (2024), 64(1):1-14.

13. Kumari P, Szabolcs Dvoracsko, Michael D. Enos, Karthik Ramesh, Darrix Lim Sergio A. Hassan, George Kunos , Resat Cinar, Malliga R. Iyer , Daniel M. Rosenbaum. Structural mechanism of CB1R binding to peripheral and biased inverse agonists. Nature Communications 15(1):10694 (2024).

12. Kumari P, Inoue A, Chapman K, Lian P, Rosenbaum DM. Molecular mechanism of free fatty acid activation of FFAR1. PNAS 120 (22) e2219569120 (2023).

11. Pandey S*, Kumari P*, Baidya M*, Kise R, Cao Y, Dwivedi-Agnihotri H, Banerjee R, Li X, C Cui C.S, Lee J.D, Kawakami K, Maharana J, Ranjan A, Chaturvedi M, J Gagandeep, Laporte S. A, Woodruff T. M, Inoue A, Shukla A.K. Inherent bias at non-canonical β-arrestin-coupled seven transmembrane receptors. Molecular Cell 81, 1-17 (2021). *Joint first author

10. Yin J, Chen KYM, Clark MJ, Hijazi M, Kumari P, Bai XC, Sunahara RK, Barth P and Rosenbaum D. Structure of D2 dopamine receptor-G protein complex in lipid membrane. Nature 584 (7819), 125-129 (2020).

9. Baidya M*, Kumari P*, Dwivedi-Agnihotri H*, Pandey S, Chaturvedi M, Stepniewski TM., Kawakami K, Cao Y. Laporte S. A., Selent J, Inoue A. Shukla AK. Key phosphorylation sites in GPCRs orchestrate the contribution of β-Arrestin 1 in ERK1/2 activation. EMBO Reports 21, e49886 (2020). *Joint first author

(Highlighted in a News and Views article by Prof. Richard Premont published in EMBO Reports) 

8. Baidya M*, Kumari P*, Dwivedi-Agnihotri H*, Pandey S, Sokrat B, Sposini S, Chaturvedi M, Srivastava A, Roy D, Hanyaloglu AC, Bouvier M, Shukla AK. Genetically Encoded Intrabody Sensors Report the Interaction and Trafficking of β-arrestin 1 Upon Activation of G Protein-Coupled Receptors. Journal of Biological Chemistry 295, 10153-10167 (2020). *Joint first author

(Selected as the Paper of the Year in Signal-transduction category by the journal for 2020) 

7. Ghosh E, Dwivedi H, Baidya M, Srivastava A, Kumari P, Stepniewski T, Kim HR, Lee MH, van Gastel J, Chaturvedi M, Roy D, Pandey S, Maharana J, Guixà-González R, Luttrell LM, Chung KY, Dutta S, Selent J, Shukla AK. Conformational Sensors and Domain Swapping Reveal Structural and Functional Differences between β-Arrestin Isoforms. Cell Reports 28, 3287-3299 (2019).

6. Pandey S, Li X, Srivastava A, Baidya M, Kumari P, Dwivedi H, Ghosh E, Woodruff T, Shukla AK, Partial ligand-receptor engagement reveals functional bias at the human complement receptor C5aR1. Journal of Biological Chemistry 294, 9416-9429 (2019).

5. Ghosh E, Srivastav A, Baidya M, Kumari P, Dwivedi H, Nidhi K, Ranjan R, Dogra S, Koide A,Yadav P, N Sidhu, Koide S, Shukla AK. A synthetic intrabody-based selective and generic inhibitor of GPCR endocytosis. Nature Nanotechnology 12, 1190- 1198 (2017).

4. Baidya, M; Kumari, P; Shukla A. K. Entering the Pocket, Crystal Structure of a Prostaglandin D2 Receptor. Molecular Cell 72 (1), P3-6 (2018) 

3. Kumari P, Srivastava A, Ghosh E, Ranjan R, Dogra S, Yadav PN, Shukla AK. Core engagement with β-arrestin is dispensable for agonist-induced vasopressin receptor endocytosis and ERK activation. Molecular Biology of Cell 28, 1003-1010 (2017).

2. Kumari P, Srivastava A, Banerjee R, Ghosh E, Ranjan R, Chen X, Gupta B, Gupta C, Jaiman D, Shukla AK. Functional competence of a partially-engaged GPCR-β-arrestin complex. Nature Communications 7, 1-16 (2016).

1. Ghosh E; Kumari P; Jaiman D; Shukla AK. Methodological advances. The unsung heroes of the GPCR structural revolution. Nature Reviews Molecular Cell Biology, 16, 69-81 (2015).

                List of Book Chapters

 2. From recombinant expression to crystals: A step-by-step guide to GPCR crystallography. Shukla AK; Kumari P; Ghosh E; Nidhi K. Methods in Enzymology, 556, 549-561 (2015).

1. Measuring agonist-induced ERK MAP kinase phosphorylation for G protein-coupled receptors. Kumari, P; Dwivedi, H; Baidya, M and Shukla A. K. Methods in Cell Biology, 149, 141-153 (2018).

                 Google Scholar link: https://scholar.google.co.in/citations?user=fTCmLCMAAAAJ&hl=en