We are a highly interdisciplinary research group exploring the frontiers of biochemistry, structural biology, cell signaling, and molecular pharmacology. Our primary focus is on G protein-coupled receptors (GPCRs), the largest family of cell surface receptors and key targets for nearly 35% of FDA-approved drugs.

Despite their critical role, the intricate relationship between cellular membranes, lipid components, and membrane proteins remains poorly understood. Our research aims to unravel the fundamental mechanisms by which phospholipids regulate GPCR structure, function, and dynamics. Given that GPCRs span the membrane seven times, their interaction with lipids is not just incidental, it is integral to their biology.

To address these complex questions, we employ a combinatorial approach, integrating structural, biophysical, and biochemical techniques. By decoding the lipid-protein interplay, we seek to uncover novel insights into GPCR regulation, with implications for drug discovery and therapeutic innovation.

Join us as we push the boundaries of membrane protein structural biology and signaling!