Research

Research Areas

1. Cancer Biology and Molecular Oncology

Our research aims to elucidate the molecular mechanisms underlying cancer initiation, progression, metastasis, and therapeutic resistance. We investigate signaling pathways regulating cell proliferation, apoptosis, angiogenesis, invasion, and metastasis to identify novel therapeutic targets for cancer treatment.

2. Tumor Microenvironment and Hypoxia

A major focus of our laboratory is understanding the role of the tumor microenvironment in cancer progression, with particular emphasis on hypoxia. We study how oxygen deprivation influences gene expression, cellular metabolism, immune evasion, and resistance to chemotherapy, thereby contributing to aggressive tumor behavior and poor clinical outcomes.

3. Nanomedicine and Targeted Drug Delivery

We develop nanotechnology-based drug delivery systems for selective and efficient cancer therapy. Our research involves the design of smart nanocarriers capable of responding to tumor-specific conditions such as acidic pH, elevated reactive oxygen species, and hypoxia, thereby improving therapeutic efficacy while reducing systemic toxicity.

4. Medicinal Inorganic Chemistry and Metal-Based Therapeutics

Our laboratory investigates the anticancer potential of metal-based compounds, including ruthenium, osmium, rhenium, organotin, and related complexes. These compounds are evaluated for their ability to induce selective cancer cell death through reactive oxygen species generation, mitochondrial dysfunction, DNA damage, and apoptosis induction.

5. Molecular Imaging and Cancer Theranostics

We develop multifunctional nanomaterials and fluorescent probes for simultaneous cancer diagnosis and therapy. These theranostic platforms enable real-time tumor imaging, monitoring of treatment response, and targeted therapeutic intervention, supporting the advancement of personalized medicine.

Recently Published Papers