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Praachi is currently working on exploring the therapeutic potential of psilocybin in mental health disorders in clinical settings, and identifying underlying mechanism of action using preclinical rat models at the Center for Psychedelics and Consciousness Research, and Division of Behavioral Biology, Johns Hopkins School of Medicine. She is working towards establishing protocols that can robustly comment on the translatability of the experimental designs across clinical and preclinical studies.
Currently, she is aims to understand the actions of psilocybin on Obsessive Compulsive Disorders both clinically and mechanistically.
Her interest in psychedelics started with her PhD work. During her PhD, Praachi worked with serotonergic psychedelics primarily used in preclinical rodent models, like DOI (2,5-dimethoxy-4-iodoamphetamine), to understand how they act on mood-related behaviours, especially anxiety-like behaviour. She elucidated the neural circuit that programs anxiolytic behaviour in rodents in response to psychedelic administration.
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