Understanding immune-microbiota interaction in health and diseases

 Our lab is interested in the interaction between intestinal immune system and gut microbiota. The alteration of gut microbiota contributes to the pathogenesis of various intractable disease, but the underlying mechanisms largely remain elusive. We believe that alteration of gut microbiota is not sufficient to influence the pathogenesis of diseases but receiprocal interaction between immune system an gut microbiota is more decisive.

Our current research focuses on

1) Role of diet and gut microbiota in shaping intestinal immunity
2) Development regulation of immune responses against gut microbiota
3) Role of pathobiont species in the pathogenesis of inflammatory bowel disease
4) Immune-microbiota interaction in non-alcoholic fatty liver disease
5) Development of microbiome-based/targeted therapeutics
6) Species/strain-specific regulation of intestinal immunity
7) Regulation of anti-tumor immunity by gut microbiota