Smoldering Multiple Myeloma (SMM) is a precursor condition to multiple myeloma, a type of cancer that affects plasma cells in the bone marrow. Unlike multiple myeloma, SMM does not typically cause symptoms, and patients may not even be aware of its presence. However, it is considered a higher risk state for developing active multiple myeloma.

Here are some key points about Smoldering Multiple Myeloma and its effects on the blood cells and the human body over time:

1. **Definition:** Smoldering Multiple Myeloma is characterized by the presence of abnormal plasma cells in the bone marrow and/or abnormal levels of certain proteins in the blood or urine. It is often diagnosed through routine blood tests or imaging studies.

2. **Asymptomatic Stage:** Unlike active multiple myeloma, SMM does not usually cause symptoms such as bone pain, fatigue, or recurrent infections. Many individuals with SMM may not even be aware of their condition.

3. **Risk of Progression:** One of the key aspects of SMM is its potential to progress to active multiple myeloma over time. While not all cases progress, there is a risk, and regular monitoring is crucial.

4. **Impact on Blood Cells:** Smoldering Multiple Myeloma affects blood cells by causing an overproduction of abnormal plasma cells. Plasma cells are a type of white blood cell that produces antibodies to help the body fight infections. In SMM, these plasma cells become cancerous and can crowd out normal cells in the bone marrow.

5. **Bone Marrow Infiltration:** The presence of abnormal plasma cells in the bone marrow can lead to bone marrow infiltration, affecting the normal production of other blood cells, such as red blood cells and platelets.

6. **Diagnostic Criteria:** Diagnosis of SMM is based on specific criteria, including the percentage of abnormal plasma cells in the bone marrow, the presence of certain proteins in the blood or urine, and the absence of myeloma-related symptoms.

7. **Management and Monitoring:** Individuals diagnosed with Smoldering Multiple Myeloma are often closely monitored by healthcare professionals. Treatment may not be initiated immediately, but regular assessments are conducted to detect any signs of progression.

It's important to note that each case of Smoldering Multiple Myeloma is unique, and the risk of progression can vary among individuals. Management decisions are typically made on a case-by-case basis. If you need more detailed information or specific studies/articles, I recommend consulting medical literature or seeking information from reputable medical sources.