A 1st research axis aims at determining the functional links between epigenome dynamics and gene expression reprogramming.

This axis notably aims at determining:

• the molecular frameworks and chromatin factors that integrate light signaling in the epigenome to modulate gene expression

• how the sequential orchestration of epigenome changes at light-regulated genes, heterochromatin dynamics, and 3D changes in genome topology, interplay to modulate both the general transcriptional regime and gene-specific expression patterns

Project coordinated by Fredy Barneche & Clara Richet-Bourbousse and funded by ANR

In a 2nd axis, we explore whether chromatin integration of light perception can trigger a short-term priming to light stress.

This axis notably aims at determining:

• light sensitization relies on signal integration at the chromatin level, e.g. upon transcription or gene repression

• such  a short-term memory potentiates rapid adaptations to stress re-exposure and possibly relies on gene priming through local chromatin state regulation.

Project coordinated by Fredy Barneche and funded by the EpiSeedLink MSCA Doctoral Network

Addressing both plant-specific and evolutionarily-conserved processes, this project contributes to current intense efforts devoted to decipher the mechanisms underpinning cellular and organismal adaptive responses. It is also aimed at tackling the biotechnological potential of chromatin regulatory mechanisms for improving plant cultivation under environmental stress.