Side Effects of PBD

Issues of Toxicity

Figure 22. Various types of toxicity induced by PBDs.³⁸

Cancer patients undergoing platinum-based drug therapies often deal with a plethora of symptoms and side-effects.

Up to 90% of patients in a 2013 study experienced gastrointestinal symptoms such as nausea and vomiting.¹⁵
Some of the most common side effects of cisplatin include
- respiratory problems,
- constitutional symptoms such as fatigue and fever,
- nephrotoxicity (toxicity of the kidneys), and
- dermatological disorders such as rashes.^{15, 16}

Abnormal tongue sensation
black, tarry stools
bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
bleeding gums
blistering, peeling, redness, or swelling of the palms of the hands or bottoms of the feet
blood in the urine or stools
burning, prickling, itching, or tingling of the skin
chest pain
chills
cough
decreased urination
difficulty performing daily activities such as writing, buttoning, swallowing, or walking
difficulty with articulating words
dizziness
dry mouth
eye pain
fainting
fever
increase in heart rate
jaw spasm
lightheadedness
lower back or side pain
muscle pain or stiffness
numbness or painful sensations
pain in the chest, groin, or legs, especially the calves and joints
painful or difficult urination
pinpoint red spots on the skin
rapid breathing
sensation of pins and needles
sore throat
sores, ulcers, or white spots on the lips or in the mouth
sunken eyes
swelling or inflammation of the mouth
swollen glands
thirst
troubled breathing with exertion
unsteadiness or awkwardness
unusual bleeding or bruising
unusual tiredness or weakness
vision changes
wrinkled skin

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