Embedded Files
Structure and Properties
Structure and Properties
Figure 10. Carboplatin, a classical platinum-based drug.
Carboplatin, [Pt(CBDCA-O,O‘)(NH3)2] (CBDCA is cyclobutane-1,1-dicarboxylate), is considered a second-generation drug.4 Scientists in the 1970s tested derivatives of cisplatin, which led to the discovery of carboplatin.9,10 It was developed to reduce the dangerous side effects of cisplatin; consequently, it is less effective due to its lower reactivity in the body.11 Carboplatin has since replaced cisplatin for the treatment of ovarian cancer, but has limited efficiency with testicular and bladder cancer and squamous cell carcinoma.4
Similar to classic platinum-based anticancer drugs, carboplatin has a square planar geometry where the platinum +4 ion is neutralized by four ligands as shown in Figure 10. Two of the ligands are cis ammonia groups and the other ligand is a bidentate cyclobutane-dicarboxylates containing oxygen.11
Carboplatin proves a (potentially) viable treatment for breast cancer
Sibylle Loibl, MD, PhD, from the University of Frankfurt believes that carboplatin has shown great promise in the treatment of triple-negative breast cancer.
Figure 11. Carboplatin is delivered intravenously like many platinum-based drugs.34
Page updated
Google Sites
Report abuse