Plasmodial slime molds, not to be confused with cellular slime molds, are an organism composed of one, blob-like cell, called a plasmodium. In nature they are known for feeding upon dead and decaying plant material. In captivity, many researcher study the feeding and growth behaviors of slime molds since these ancestral organisms have an uncanny ability to find and "solve" spatial puzzles.
Above: macroscopic plasmodium of Physarum polycephalum
Above: Plasmodium of Physarum
Fungal-like protists, which are heterotrophic
e.g. Physarum
Found in open forests, but also in extreme regions such as deserts, under snow blankets, or underwater
They also occur on the bark of trees, sometimes high in the canopy
The structure is one large cell called a plasmodium, which is a macroscopic coenocytic mass without cells walls
When conditions are unfavorable for growth, slime molds create a sclerotium, which is an encrusting phase
Above: Sclerotium of Trichia
May represent an ancestral protist with sexual reproduction (diplontic?)
Spore cases (sporangia) are produced when conditions become unfavorable such as too warm, dry, or bright
Through meiosis, spores are created, which germinates into a unicellular amoeba-like cell or a flagellated cell
These "gametes" fuse with another in plasmogamy, and then kayogamy to create a zygote (amoebozygote)
Through mitosis, the zygote grows into a plasmodium once again
Above: sporangia of a slime mold
Unikonta - single-flagellum organisms
└Amoebozoa - amoeba-like organism
└Mycetozoa - slime molds
└Myxomycota - plasmoidal slime molds
Worldwide distribution; common in temperate regions
Over 60 genera and almost 900 species
??? - present (poor fossil record)
Slime mold soil microbes could be a source of potent antimicrobials (Phys.org 8Oct2025)
└Production of anti-bacterial compounds by a Steely hybrid polyketide synthase in Dictyostelium (Yamashita et al., 2025)
A Brainless Blob That Can Think Is Being Sent to Space to See What Happens (VICE 3Aug2021)
This Weirdly Smart, Creeping Slime Is Redefining Our Understanding of Intelligence (ScienceAlert 12Jun2021)
Slime molds remember food locations (Phys.org, Feb 2021)
Computing with slime molds (Elsevier 27Mar2014)
Slime molds have memory, but no brain (National Geographic 10Oct2012)
Slime Design Mimics Tokyo's Rail System (Science Daily 22Jan2010)
Even Single-Celled Organisms Feed Themselves in 'Smart' Manner (Science Daily 15Feb2010)