# Tools
# Tools
AlphaFold is an artificial intelligence system created by Google DeepMind that predicts the three-dimensional shapes of proteins based on their genetic sequences.
Foldseek Search Server is an ultra-fast and sensitive tool that compares protein three-dimensional structures against massive databases by converting their shapes into one-dimensional sequences.
DALI Server is an online tool used to compare the three-dimensional shapes of proteins.
Protein Data Bank is the database for experimentally determined three-dimensional (3D) structural data of biological macromolecules, including proteins, DNA, and RNA.
PyMOL is a Python-based molecular visualization system used to create high-quality 3D images and animations of biological macromolecules like proteins and small molecules.
antiSMASH stands for Antibiotics and Secondary Metabolite Analysis Shell is an online tool to identify, annotate, and analyze biosynthetic gene clusters in bacterial, archaeal, and fungal genomes.
JGI IMG/M stands for Integrated Microbial Genomes & Microbiomes is a platform for annotation, analysis, visualization, and distribution of microbial genomes, metagenomes, and microbiome datasets sequenced at DOE Joint Genome Institute (JGI).
MiBIG stands for Minimum Information about a Biosynthetic Gene cluster database is a standardized, open-access repository for experimentally characterized biosynthetic gene clusters and their secondary metabolite products.
BiG-SCAPE/CORASON stands for Biosynthetic Gene Similarity Clustering and Prospecting Engine (BiG-SCAPE) and CORe Analysis of Syntenic Orthologues to prioritize Natural product gene clusters (CORASON), is a combined computational framework used to explore and analyze the large-scale diversity and evolutionary relationships of biosynthetic gene clusters across numerous genomes.
BiG-FAM stands for Biosynthetic Gene Family is an online database and global "atlas" of microbial secondary metabolic diversity that groups homologous biosynthetic gene clusters into Gene Cluster Families.
BLAST stands for Basic Local Alignment Search Tool is used to compare a DNA, RNA or protein sequence against a database to find regions of local similarity and identify unknown sequences.
NCBI stands for National Center for Biotechnology Information is used to store, analyze, and retrieve public biomedical, genetic, and genomic information.
UniProt is a database of protein sequence and functional information.
InterPro is a database that classifies protein sequences into families and predicts important functional domains and sites.
EFI-EST stands for Enzyme Function Initiative-Enzyme Similarity Tool is a web-based bioinformatics pipeline used to generate protein Sequence Similarity Networks for large-scale functional analysis and enzyme discovery.
Cytoscape is a software designed for visualizing, analyzing, and integrating complex networks and biological pathways.
RODEO stands for Rapid ORF Description and Evaluation Online is an algorithm designed to help with biosynthetic gene cluster analysis, with a primary focus on the discovery and prediction of ribosomal natural products.
MEGA stands for Molecular Evolutionary Genetics Analysis is a software designed for building phylogenetic trees and analyzing molecular evolution.
Clustal Omega is a multiple sequence alignment tool used to align DNA, RNA or protein sequences.
WebLogo is a web-based tool designed to generate amino acids or nucleic acids sequence logos.
ApE stands for A Plasmid Editor is a software used to visualize, design, and analyze DNA sequences and plasmids.
ChemDraw is a software used to draw, visualize, and study chemical structures, reactions, and biological pathways.
GNPS stands for Global Natural Products Social Molecular Networking platform is a web-based mass spectrometry ecosystem designed for the open-access sharing, organization, and analysis of tandem mass spectrometry data.