Phan Lab - Publications

# Publications (†Co-first author, *Corresponding author)

60) Haedar J. R.,† Kumari G. S.,† [...], Phan C.-S.* P450 cyptide synthase KwwB catalyzes Trp-C5−Trp-N1 cross-linking and accepts diverse precursor peptides. Org. Lett. 2026. Link

59) Haedar J. R.,† Khan A. H.,†Coxon C. R.,* Phan C.-S.* Cyanobacterial cyclic peptides containing cis Pro conformation. Chem. Eur. J. 2026, accepted.

58) Haedar J. R., [...], Phan C.-S.* S9 protease WprP catalyzes uniform and sequential cleavage on the precursor peptide in RiPP biosynthesis. bioRxiv 2025. Link

57) Khan A. H., [...], Phan C.-S.* P450 biarylitide synthase ShyB catalyzes cross-link between His-C2 and Tyr-O4 on the precursor peptide. Org. Lett. 2025, 27, 5715–5719. Link

56) Khan A. H., [...], Phan C.-S.* P450 cyptide synthase MpoB catalyzes the cross-link of YPW motif on the precursor peptide. RSC Chem. Biol. 2025, 6, 1386-1390. Link

55) Khan A. H.,† Haedar J. R.,† [...], Phan C.-S.* Radical SAM enzyme WprB catalyzes uniform cross-link topology between Trp-C5 and Arg-Cγ on the precursor peptide. ACS Chem. Biol. 2025, 20, 259-265. Link Featured in American Peptide Society

54) Khan A. H., Phan C.-S.* Marine natural products from Malaysia. In: Tan L. T., Hanif N. (eds) Marine natural products research in South-East Asia. Springer, Cham, 2025, pp 183-225. Link (Invited submission)

53) Khan A. H., […], Phan C.-S.* Radical SAM cyclophane synthase catalyzes uniform cyclophane formation at multiple Trp-motifs. Tetrahedron Chem 2025, 14, 100128. Link

52) Khan A. H., Phan C.-S.* Recent advancement of cyanobactins and cyanobactin prenyltransferases from 2021 to 2024. Front. Nat. Prod. 2025, 4, 1616031. Link (Invited submission)

51) Haedar J. R.,† Khan A. H.,† Zīle A., Phan C.-S.* The advancement of peptides derived from Kitasatospora. Chem. Biodivers. 2025, 22, e202402999. Link (Invited submission)

50) Zdouc M. M.,† Blin K.,† […], Phan C.-S., et al. MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration. Nucleic Acids Res. 2025, 53, D678-D690. Link

49) Ishigami S., […], Phan C.-S., Ishii T. Anti-biofouling marine diterpenoids from Okinawan soft corals. Biofouling 2025, 41, 103-112. Link

48) Modaresi S. M.,† Sugiyama R.,† Tram N. D. T.,† Jakob R. P., Phan C.-S., et al. Antibiotics that kill Gram-negative bacteria by restructuring the outer membrane protein BamA. bioRxiv 2024. Link Patent PCT/SG2023/050524

47) Phan C.-S.,† Ling Z.,† Mehjabin J. J.,† et al. Doubly homologated tyrosine-containing peptides from the cyanobacterium Microcystis aeruginosa NIES-4285 and their biosynthesis. J. Nat. Prod. 2024, 87, 2629-2639. Link

46) Phan C.-S., Morinaka B. I. Sequence-function space of radical SAM cyclophane synthases reveal conserved active site residues that influence substrate specificity. RSC Chem. Biol. 2024, 5, 1195-1200. Link

45) Mehjabin J. J.,† Phan C.-S.,† Okino T. Noducyclamides A1-A4, B1, and B2 from the cyanobacterium Nodularia sp. NIES-3585. J. Nat. Prod. 2024, 87, 984-993. Link

44) Phan C.-S., et al. Substrate promiscuity of the triceptide maturase XncB leads to incorporation of various amino acids and detection of oxygen adducts. ACS Chem. Biol. 2024, 19, 855-860. Link

43) Phan C.-S., Morinaka B. I. Bacterial cyclophane-containing RiPPs from radical SAM enzymes. Nat. Prod. Rep. 2024, 41, 708-720. Link Featured in Cover Page

42) Balloo N., Mehjabin J. J., Phan C.-S., Okino T. Heat shock and iron limitation modulate the metabolic profile of the cyanobacterium Microcystis aeruginosa NIES-88. Phycol. Res. 2023, 71, 200-208. Link

41) Phan C.-S., Morinaka B. I. A prevalent group of actinobacterial radical SAM/SPASM maturases involved in triceptide biosynthesis. ACS Chem. Biol. 2022, 17, 3284-3289. Link

40) Phan C.-S.,† Mehjabin J. J.,† et al. Nostosin G and spiroidesin B from the cyanobacterium Dolichospermum sp. NIES-1697. J. Nat. Prod. 2022, 85, 2000-2005. Link

39) Tani K., Kamada T., Phan C.-S., et al. New bioactive sesquiterpenoid from Malaysian soft coral genus Lemnalia. Heterocycles 2022, 104, 1469-1476. Link

38) Sbaraini N., Phan C.-S., et al. Intra-hemocoel injection of pseurotin A from Metarhizium anisopliae, induces dose-dependent reversible paralysis in the Greater Wax Moth (Galleria mellonella). Fungal Genet. Biol. 2022, 159, 103675. Link

37) Ishii T., Sato K., Ito G., Kawano J., Takabe W., Phan C.-S., et al. Unusual cembrane diterpenoid isolated from the Japanese soft coral genus Sinularia. Heterocycles 2022, 104, 797-803. Link

36) Phan C.-S.,† Matsuda K.,† et al. Argicyclamides A-C unveil enzymatic basis for guanidine bis-prenylation. J. Am. Chem. Soc. 2021, 143, 10083-10087. Link Patent PCT/JP2022/004501 Featured in Press Release

35) Sbaraini N., Hu J., Roux I., Phan C.-S., et al. Polyketides produced by the entomopathogenic fungus Metarhizium anisopliae induce Candida albicans growth. Fungal Genet. Biol. 2021, 152, 103568. Link

34) Li H., Glichrist C. L. M., Phan C.-S., et al. Biosynthesis of a new benzazepine alkaloid nanangelenin A from Aspergillus nanangensis involves an unusual L-kynurenine-incorporating NRPS catalyzing regioselective lactamization. J. Am. Chem. Soc. 2020, 142, 7145-7152. Link

33) Ng S.-Y., Phan C.-S., et al. Terpenoids from marine soft coral of the genus Xenia in 1977 to 2019. Molecules 2020, 25, 5386. Link

32) Phan C.-S., et al. Two new epimers of C15-acetogenin, 4-epi-isolaurallene and 4-epi-itomanallene A as diastereomeric model. Nat. Prod. Res. 2020, 34, 1008-1013. Link

31) Kamada T., Johanis M. L., Ng S.-Y., Phan C.-S., et al. A new epi-neoverrucosane-type diterpenoid from the liverwort Pleurozia subinflata in Borneo. Nat. Prod. Bioprospect. 2020, 10, 51-56. Link

30) Phan C.-S., et al. Bipolenins K–N: new sesquiterpenoids from the fungal plant pathogen Bipolaris sorokiniana. Beilstein J. Org. Chem. 2019, 15, 2020-2028. Link

29) Tani K., Kamada T., Phan C.-S., et al. New cembrane-type diterpenoids from Bornean soft coral Nephthea sp. with antifungal activity against Lagenidium thermophilum. Nat. Prod. Res. 2019, 33, 3343-3349. Link

28) Phan C.-S., et al. Cytotoxic sesquiterpenoids from soft coral Capnella imbricata. Nat. Prod. Commun. 2019, 14, 1-4. Link

27) Tani K., Kamada T., Phan C.-S., et al. A new bioactive cembranoid sarcophytonolide V from Bornean soft coral genus Sarcophyton. Nat. Prod. Commun. 2019, 14, 1-4. Link

26) Hamada T., Matsumoto Y., Phan C.-S., et al. Aaptamine-related alkaloid from the marine sponge Aaptos aaptos. Nat. Prod. Commun. 2019, 14, 1-3. Link

25) Kamada T., Phan C.-S., et al. Cytotoxicity and antibacterial potential of halogenated chamigrenes from Malaysian red alga, Laurencia majuscula. Planta Medica International Open 2019, 6, e36-e40. Link

24) Phan C.-S., et al. Sinulaflexiolide P, a cembrane-type diterpenoid from the Bornean soft coral Sinularia flexibilis. Chem. Nat. Comp. 2019, 55, 285-288. Link

23) Phan C.-S., et al. 12-Epi-9-deacetoxyxenicin, new cytotoxic diterpenoid from a Bornean soft coral, Xenia sp. Nat. Prod. Res. 2019, 33, 808-813. Link

22) Shamsudin K. J., Phan C.-S., et al. Leucoxenols A and B, two new phenolics from Bornean medicinal plant Syzygium leucoxylon. J. Asian Nat. Prod. Res. 2019, 21, 435-441. Link

21) Kamada T., Phan C.-S., et al. New anti-bacterial halogenated tricyclic sesquiterpenes from Bornean Laurencia majuscula (Harvey) Lucas. Nat. Prod. Res. 2019, 33, 464-471. Link

20) Kamada T., Phan C.-S., et al. Nangallenes A and B, halogenated nonterpenoid C15-acetogenins from the Bornean red alga Laurencia nangii. J. Asian Nat. Prod. Res. 2019, 21, 241-247. Link

19) Kamada T., Phan C.-S., et al. Neoiriepentaol and nangenyne, halogenated diterpenoid and C15-acetonenin from red alga Laurencia nangii Masuda collected in Borneo. J. Appl. Phycol. 2018, 30, 3379-3386. Link

18) Kamada T., Phan C.-S., et al. Halogenated chamigrane sesquiterpenes from Bornean Laurencia majuscula. J. Appl. Phycol. 2018, 30, 3373-3378. Link

17) Ng S.-Y., Kamada T., Phan C.-S., et al. New prenylated bibenzyls from Bornean liverwort Acrobolbus saccatus. Heterocycles 2018, 96, 1958-1965. Link

16) Phan C.-S., et al. Paralemnolins V and W, new nardosinane-type sesquiterpenoids from a Bornean soft coral, Lemnalia sp. Chem. Nat. Comp. 2018, 54, 903-906. Link

15) Kamada T., Kang M.-C., Phan C.-S., et al. Bioactive cembranoids from the soft coral genus Sinularia sp. in Borneo. Mar. Drugs 2018, 16, 99. Link

14) Phan C.-S., et al. Cytotoxic sesterterpenoids from Bornean sponge Spongia sp. Rec. Nat. Prod. 2018, 12, 643-647. Link

13) Phan C.-S., et al. 15-Deoxy-isoxeniolide-A, new diterpenoid from a Bornean soft coral, Xenia sp. Nat. Prod. Res. 2018, 32, 202-207. Link

12) Kamada T., Ng S.-Y., Phan C.-S., et al. Chemical composition and antibacterial activity of Bornean medicinal ginger Alpinia aquatica. Nat. Prod. Commun. 2018, 13, 741-742. Link

11) Hatai K., Kamada T., Lau L.-M., Kulip J., Phan C.-S., et al. In vitro inhibitory effects of two Bornean medicinal wild gingers against pathogenic Lagenidium thermophilum infected mud crab Scylla tranquebarica. Biocontrol Sci. 2018, 23, 35-39. Link

10) Kamada T., Zanil I. I., Phan C.-S., et al. A new cembrane, from soft coral genus Sarcophyton in Borneo. Nat. Prod. Commun. 2018, 13, 123-124. Link

9) Kamada T., Phan C.-S., et al. Cytotoxic and antifungal terpenoids from Bornean soft coral, Sinularia flexibilis. Nat. Prod. Commun. 2018, 13, 17-19. Link

8) Phan C.-S., et al. A new guaiane-type sesquiterpenoid from a Bornean soft coral, Xenia stellifera. Nat. Prod. Commun. 2018, 13, 15-16. Link

7) Kamada T., Kulip J., Tani K., Phan C.-S., et al. Phillipsins A and B from Zingiber phillippsii Mood & Theilade in Borneo. Rec. Nat. Prod. 2018, 12, 317-322. Link

6) Ishii T., Kamada T., Phan C.-S., et al. Chabrolene, a novel norditerpene from the Bornean soft coral Nephthea sp. Sains Malays. 2018, 47, 319-322. Link

5) Phan C.-S., et al. Capgermacrenes D-G, new sesquiterpenoids from a Bornean soft coral, Capnella imbricata. Nat. Prod. Res. 2017, 31, 742-748. Link

4) Ishii T., Phan C.-S., et al. Capgermacrene C, a new sesquiterpenoid from a Bornean soft coral, Capnella sp. Nat. Prod. Commun. 2016, 11, 1065-1066. Link

3) Phan C.-S., et al. Two new lobane diterpenes from a Bornean soft coral Sinularia sp. Nat. Prod. Commun. 2016, 11, 899-900. Link

2) Kamada T., Phan C.-S., et al. 16-Hydroxycembra-1,3,7,11-tetraene, a new cembrane diterpene from Malaysian soft coral genus Sarcophyton. Nat. Prod. Commun. 2016, 11, 1077-1078. Link

1) Phan C.-S., et al. Capgermacrenes A and B, bioactive secondary metabolites from a Bornean soft coral, Capnella sp. Mar. Drugs 2015, 13, 3103-3115. Link

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