# Publications (†Co-first author, *Corresponding author)
58) Haedar J. R., [...], Phan C.-S.* S9 protease WprP catalyzes uniform and sequential cleavage on the precursor peptide in RiPP biosynthesis. bioRxiv 2025. Link
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57) Khan A. H., [...], Phan C.-S.* P450 biarylitide synthase ShyB catalyzes cross-link between His-C2 and Tyr-O4 on the precursor peptide. Org. Lett. 2025, 27, 5715–5719. Link
56) Khan A. H., [...], Phan C.-S.* P450 cyptide synthase MpoB catalyzes the cross-link of YPW motif on the precursor peptide. RSC Chem. Biol. 2025, 6, 1386-1390. Link Featured in Emerging Investigator
55) Khan A. H.,† Haedar J. R.,† [...], Phan C.-S.* Radical SAM enzyme WprB catalyzes uniform cross-link topology between Trp-C5 and Arg-Cγ on the precursor peptide. ACS Chem. Biol. 2025, 20, 259-265. Link Featured in American Peptide Society
54) Khan A. H., Phan C.-S.* Marine natural products from Malaysia. In: Tan L. T., Hanif N. (eds) Marine natural products research in South-East Asia. Springer, Cham, 2025, pp 183-225. Link (Invited submission)
53) Khan A. H., […], Phan C.-S.* Radical SAM cyclophane synthase catalyzes uniform cyclophane formation at multiple Trp-motifs. Tetrahedron Chem 2025, 14, 100128. Link
52) Khan A. H., Phan C.-S.* Recent advancement of cyanobactins and cyanobactin prenyltransferases from 2021 to 2024. Front. Nat. Prod. 2025, 4, 1616031. Link (Invited submission)
51) Haedar J. R.,† Khan A. H.,† Zīle A., Phan C.-S.* The advancement of peptides derived from Kitasatospora. Chem. Biodivers. 2025, 22, e202402999. Link (Invited submission)
50) Zdouc M. M.,† Blin K.,† […], Phan C.-S., et al. MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration. Nucleic Acids Res. 2025, 53, D678-D690. Link
49) Ishigami S., […], Phan C.-S., Ishii T. Anti-biofouling marine diterpenoids from Okinawan soft corals. Biofouling 2025, 41, 103-112. Link
48) Modaresi S. M.,† Sugiyama R.,† Tram N. D. T.,† Jakob R. P., Phan C.-S., et al. Antibiotics that kill Gram-negative bacteria by restructuring the outer membrane protein BamA. bioRxiv 2024. Link Patent PCT/SG2023/050524
47) Phan C.-S.,† Ling Z.,† Mehjabin J. J.,† et al. Doubly homologated tyrosine-containing peptides from the cyanobacterium Microcystis aeruginosa NIES-4285 and their biosynthesis. J. Nat. Prod. 2024, 87, 2629-2639. Link
46) Phan C.-S., Morinaka B. I. Sequence-function space of radical SAM cyclophane synthases reveal conserved active site residues that influence substrate specificity. RSC Chem. Biol. 2024, 5, 1195-1200. Link
45) Mehjabin J. J.,† Phan C.-S.,† Okino T. Noducyclamides A1-A4, B1, and B2 from the cyanobacterium Nodularia sp. NIES-3585. J. Nat. Prod. 2024, 87, 984-993. Link
44) Phan C.-S., et al. Substrate promiscuity of the triceptide maturase XncB leads to incorporation of various amino acids and detection of oxygen adducts. ACS Chem. Biol. 2024, 19, 855-860. Link
43) Phan C.-S., Morinaka B. I. Bacterial cyclophane-containing RiPPs from radical SAM enzymes. Nat. Prod. Rep. 2024, 41, 708-720. Link Featured in Cover Page
42) Balloo N., Mehjabin J. J., Phan C.-S., Okino T. Heat shock and iron limitation modulate the metabolic profile of the cyanobacterium Microcystis aeruginosa NIES-88. Phycol. Res. 2023, 71, 200-208. Link
41) Phan C.-S., Morinaka B. I. A prevalent group of actinobacterial radical SAM/SPASM maturases involved in triceptide biosynthesis. ACS Chem. Biol. 2022, 17, 3284-3289. Link
40) Phan C.-S.,† Mehjabin J. J.,† et al. Nostosin G and spiroidesin B from the cyanobacterium Dolichospermum sp. NIES-1697. J. Nat. Prod. 2022, 85, 2000-2005. Link
39) Tani K., Kamada T., Phan C.-S., et al. New bioactive sesquiterpenoid from Malaysian soft coral genus Lemnalia. Heterocycles 2022, 104, 1469-1476. Link
38) Sbaraini N., Phan C.-S., et al. Intra-hemocoel injection of pseurotin A from Metarhizium anisopliae, induces dose-dependent reversible paralysis in the Greater Wax Moth (Galleria mellonella). Fungal Genet. Biol. 2022, 159, 103675. Link
37) Ishii T., Sato K., Ito G., Kawano J., Takabe W., Phan C.-S., et al. Unusual cembrane diterpenoid isolated from the Japanese soft coral genus Sinularia. Heterocycles 2022, 104, 797-803. Link
36) Phan C.-S.,† Matsuda K.,† et al. Argicyclamides A-C unveil enzymatic basis for guanidine bis-prenylation. J. Am. Chem. Soc. 2021, 143, 10083-10087. Link Patent PCT/JP2022/004501 Featured in Press Release
35) Sbaraini N., Hu J., Roux I., Phan C.-S., et al. Polyketides produced by the entomopathogenic fungus Metarhizium anisopliae induce Candida albicans growth. Fungal Genet. Biol. 2021, 152, 103568. Link
34) Li H., Glichrist C. L. M., Phan C.-S., et al. Biosynthesis of a new benzazepine alkaloid nanangelenin A from Aspergillus nanangensis involves an unusual L-kynurenine-incorporating NRPS catalyzing regioselective lactamization. J. Am. Chem. Soc. 2020, 142, 7145-7152. Link
33) Ng S.-Y., Phan C.-S., et al. Terpenoids from marine soft coral of the genus Xenia in 1977 to 2019. Molecules 2020, 25, 5386. Link
32) Phan C.-S., et al. Two new epimers of C15-acetogenin, 4-epi-isolaurallene and 4-epi-itomanallene A as diastereomeric model. Nat. Prod. Res. 2020, 34, 1008-1013. Link
31) Kamada T., Johanis M. L., Ng S.-Y., Phan C.-S., et al. A new epi-neoverrucosane-type diterpenoid from the liverwort Pleurozia subinflata in Borneo. Nat. Prod. Bioprospect. 2020, 10, 51-56. Link
30) Phan C.-S., et al. Bipolenins K–N: new sesquiterpenoids from the fungal plant pathogen Bipolaris sorokiniana. Beilstein J. Org. Chem. 2019, 15, 2020-2028. Link
29) Tani K., Kamada T., Phan C.-S., et al. New cembrane-type diterpenoids from Bornean soft coral Nephthea sp. with antifungal activity against Lagenidium thermophilum. Nat. Prod. Res. 2019, 33, 3343-3349. Link
28) Phan C.-S., et al. Cytotoxic sesquiterpenoids from soft coral Capnella imbricata. Nat. Prod. Commun. 2019, 14, 1-4. Link
27) Tani K., Kamada T., Phan C.-S., et al. A new bioactive cembranoid sarcophytonolide V from Bornean soft coral genus Sarcophyton. Nat. Prod. Commun. 2019, 14, 1-4. Link
26) Hamada T., Matsumoto Y., Phan C.-S., et al. Aaptamine-related alkaloid from the marine sponge Aaptos aaptos. Nat. Prod. Commun. 2019, 14, 1-3. Link
25) Kamada T., Phan C.-S., et al. Cytotoxicity and antibacterial potential of halogenated chamigrenes from Malaysian red alga, Laurencia majuscula. Planta Medica International Open 2019, 6, e36-e40. Link
24) Phan C.-S., et al. Sinulaflexiolide P, a cembrane-type diterpenoid from the Bornean soft coral Sinularia flexibilis. Chem. Nat. Comp. 2019, 55, 285-288. Link
23) Phan C.-S., et al. 12-Epi-9-deacetoxyxenicin, new cytotoxic diterpenoid from a Bornean soft coral, Xenia sp. Nat. Prod. Res. 2019, 33, 808-813. Link
22) Shamsudin K. J., Phan C.-S., et al. Leucoxenols A and B, two new phenolics from Bornean medicinal plant Syzygium leucoxylon. J. Asian Nat. Prod. Res. 2019, 21, 435-441. Link
21) Kamada T., Phan C.-S., et al. New anti-bacterial halogenated tricyclic sesquiterpenes from Bornean Laurencia majuscula (Harvey) Lucas. Nat. Prod. Res. 2019, 33, 464-471. Link
20) Kamada T., Phan C.-S., et al. Nangallenes A and B, halogenated nonterpenoid C15-acetogenins from the Bornean red alga Laurencia nangii. J. Asian Nat. Prod. Res. 2019, 21, 241-247. Link
19) Kamada T., Phan C.-S., et al. Neoiriepentaol and nangenyne, halogenated diterpenoid and C15-acetonenin from red alga Laurencia nangii Masuda collected in Borneo. J. Appl. Phycol. 2018, 30, 3379-3386. Link
18) Kamada T., Phan C.-S., et al. Halogenated chamigrane sesquiterpenes from Bornean Laurencia majuscula. J. Appl. Phycol. 2018, 30, 3373-3378. Link
17) Ng S.-Y., Kamada T., Phan C.-S., et al. New prenylated bibenzyls from Bornean liverwort Acrobolbus saccatus. Heterocycles 2018, 96, 1958-1965. Link
16) Phan C.-S., et al. Paralemnolins V and W, new nardosinane-type sesquiterpenoids from a Bornean soft coral, Lemnalia sp. Chem. Nat. Comp. 2018, 54, 903-906. Link
15) Kamada T., Kang M.-C., Phan C.-S., et al. Bioactive cembranoids from the soft coral genus Sinularia sp. in Borneo. Mar. Drugs 2018, 16, 99. Link
14) Phan C.-S., et al. Cytotoxic sesterterpenoids from Bornean sponge Spongia sp. Rec. Nat. Prod. 2018, 12, 643-647. Link
13) Phan C.-S., et al. 15-Deoxy-isoxeniolide-A, new diterpenoid from a Bornean soft coral, Xenia sp. Nat. Prod. Res. 2018, 32, 202-207. Link
12) Kamada T., Ng S.-Y., Phan C.-S., et al. Chemical composition and antibacterial activity of Bornean medicinal ginger Alpinia aquatica. Nat. Prod. Commun. 2018, 13, 741-742. Link
11) Hatai K., Kamada T., Lau L.-M., Kulip J., Phan C.-S., et al. In vitro inhibitory effects of two Bornean medicinal wild gingers against pathogenic Lagenidium thermophilum infected mud crab Scylla tranquebarica. Biocontrol Sci. 2018, 23, 35-39. Link
10) Kamada T., Zanil I. I., Phan C.-S., et al. A new cembrane, from soft coral genus Sarcophyton in Borneo. Nat. Prod. Commun. 2018, 13, 123-124. Link
9) Kamada T., Phan C.-S., et al. Cytotoxic and antifungal terpenoids from Bornean soft coral, Sinularia flexibilis. Nat. Prod. Commun. 2018, 13, 17-19. Link
8) Phan C.-S., et al. A new guaiane-type sesquiterpenoid from a Bornean soft coral, Xenia stellifera. Nat. Prod. Commun. 2018, 13, 15-16. Link
7) Kamada T., Kulip J., Tani K., Phan C.-S., et al. Phillipsins A and B from Zingiber phillippsii Mood & Theilade in Borneo. Rec. Nat. Prod. 2018, 12, 317-322. Link
6) Ishii T., Kamada T., Phan C.-S., et al. Chabrolene, a novel norditerpene from the Bornean soft coral Nephthea sp. Sains Malays. 2018, 47, 319-322. Link
5) Phan C.-S., et al. Capgermacrenes D-G, new sesquiterpenoids from a Bornean soft coral, Capnella imbricata. Nat. Prod. Res. 2017, 31, 742-748. Link
4) Ishii T., Phan C.-S., et al. Capgermacrene C, a new sesquiterpenoid from a Bornean soft coral, Capnella sp. Nat. Prod. Commun. 2016, 11, 1065-1066. Link
3) Phan C.-S., et al. Two new lobane diterpenes from a Bornean soft coral Sinularia sp. Nat. Prod. Commun. 2016, 11, 899-900. Link
2) Kamada T., Phan C.-S., et al. 16-Hydroxycembra-1,3,7,11-tetraene, a new cembrane diterpene from Malaysian soft coral genus Sarcophyton. Nat. Prod. Commun. 2016, 11, 1077-1078. Link
1) Phan C.-S., et al. Capgermacrenes A and B, bioactive secondary metabolites from a Bornean soft coral, Capnella sp. Mar. Drugs 2015, 13, 3103-3115. Link
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