Phan Lab - Publications

# Publications (†Co-first author, *Corresponding author)

65) Haedar J. R.,† Wang B.,† [...], Mori T.,* Abe I.,* Phan C.-S.* 2026, coming soon.

64) Kumari G. S.,† Khan A. H.,† Haedar J. R.,* [...], Phan C.-S.* P450 cyptide synthase KwwB catalyzes non-native cross-link at Tyr-C3–Trp-N1 and tolerates leader peptide mutations. under review. 2026.

63) Haedar J. R.,† Shi Y.,† Bhatt M. A.,† Chekan J. R.,* Wang, H.,* Phan C.-S.* Radical-mediated cross-linking enzymes in RiPP biosynthesis. Nat. Prod. Rep. 2026. Link (Invited submission)

62) Haedar J. R., [...], Schäberle T. F., Phan C.-S.* Re-investigation of HExxH enzyme DarF reveals a dehydrogenation-epoxidation reaction. Org. Biomol. Chem. 2026, 24, 4583-4587. Link ; Featured in American Peptide Society

61) Haedar J. R.,† Khan A. H.,† [...], Cryle M. J., Phan C.-S.* P450 cyptide synthase AscB catalyzes fused cyclophane at the YxWxH motif on the precursor peptides. Org. Lett. 2026, 28, 5966-5971. Link

60) Haedar J. R.,† Kumari G. S.,† [...], Phan C.-S.* P450 cyptide synthase KwwB catalyzes Trp-C5−Trp-N1 cross-linking and accepts diverse precursor peptides. Org. Lett. 2026, 28, 433-437. Link

59) Haedar J. R., [...], Phan C.-S.* S9 protease WprP catalyzes uniform cleavage on the precursor peptide in RiPP biosynthesis. Commun. Chem. 2026, 9, 108. Link ; Backstory Link ; Featured in American Peptide Society

58) Haedar J. R.,† Khan A. H.,† Coxon C. R.,* Phan C.-S.* Cyanobacterial cyclic peptides containing cis Pro conformation. Chem. Eur. J. 2026, 32, e02932. Link

57) Khan A. H., [...], Phan C.-S.* P450 biarylitide synthase ShyB catalyzes cross-link between His-C2 and Tyr-O4 on the precursor peptide. Org. Lett. 2025, 27, 5715-5719. Link

56) Khan A. H., [...], Phan C.-S.* P450 cyptide synthase MpoB catalyzes the cross-link of YPW motif on the precursor peptide. RSC Chem. Biol. 2025, 6, 1386-1390. Link

55) Khan A. H.,† Haedar J. R.,† [...], Phan C.-S.* Radical SAM enzyme WprB catalyzes uniform cross-link topology between Trp-C5 and Arg-Cγ on the precursor peptide. ACS Chem. Biol. 2025, 20, 259-265. Link ; Featured in American Peptide Society

54) Khan A. H., Phan C.-S.* Marine natural products from Malaysia. In: Tan L. T., Hanif N. (eds) Marine natural products research in South-East Asia. Springer, Cham, 2025, pp 183-225. Link (Invited submission)

52) Khan A. H., Phan C.-S.* Recent advancement of cyanobactins and cyanobactin prenyltransferases from 2021 to 2024. Front. Nat. Prod. 2025, 4, 1616031. Link (Invited submission)

53) Khan A. H., […], Phan C.-S.* Radical SAM cyclophane synthase catalyzes uniform cyclophane formation at multiple Trp-motifs. Tetrahedron Chem 2025, 14, 100128. Link

51) Haedar J. R., […], Phan C.-S.* The advancement of peptides derived from Kitasatospora. Chem. Biodivers. 2025, 22, e202402999. Link (Invited submission)

50) Zdouc M. M.,† Blin K.,† […], Phan C.-S., et al. MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration. Nucleic Acids Res. 2025, 53, D678-D690. Link

49) Ishigami S., […], Phan C.-S., Ishii T. Anti-biofouling marine diterpenoids from Okinawan soft corals. Biofouling 2025, 41, 103-112. Link

48) Modaresi S. M.,† Sugiyama R.,† Tram N. D. T.,† Jakob R. P., Phan C.-S., et al. Antibiotics that kill Gram-negative bacteria by restructuring the outer membrane protein BamA. bioRxiv 2024. Link ; Patent PCT/SG2023/050524

47) Phan C.-S.,† Ling Z.,† Mehjabin J. J.,† et al. Doubly homologated tyrosine-containing peptides from the cyanobacterium Microcystis aeruginosa NIES-4285 and their biosynthesis. J. Nat. Prod. 2024, 87, 2629-2639. Link

46) Phan C.-S., Morinaka B. I. Sequence-function space of radical SAM cyclophane synthases reveal conserved active site residues that influence substrate specificity. RSC Chem. Biol. 2024, 5, 1195-1200. Link

45) Mehjabin J. J.,† Phan C.-S.,† Okino T. Noducyclamides A1-A4, B1, and B2 from the cyanobacterium Nodularia sp. NIES-3585. J. Nat. Prod. 2024, 87, 984-993. Link

44) Phan C.-S., et al. Substrate promiscuity of the triceptide maturase XncB leads to incorporation of various amino acids and detection of oxygen adducts. ACS Chem. Biol. 2024, 19, 855-860. Link

43) Phan C.-S., Morinaka B. I. Bacterial cyclophane-containing RiPPs from radical SAM enzymes. Nat. Prod. Rep. 2024, 41, 708-720. Link ; Featured in Cover Page

42) Balloo N., Mehjabin J. J., Phan C.-S., Okino T. Heat shock and iron limitation modulate the metabolic profile of the cyanobacterium Microcystis aeruginosa NIES-88. Phycol. Res. 2023, 71, 200-208. Link

41) Phan C.-S., Morinaka B. I. A prevalent group of actinobacterial radical SAM/SPASM maturases involved in triceptide biosynthesis. ACS Chem. Biol. 2022, 17, 3284-3289. Link

40) Phan C.-S.,† Mehjabin J. J.,† et al. Nostosin G and spiroidesin B from the cyanobacterium Dolichospermum sp. NIES-1697. J. Nat. Prod. 2022, 85, 2000-2005. Link

39) Tani K., Kamada T., Phan C.-S., et al. New bioactive sesquiterpenoid from Malaysian soft coral genus Lemnalia. Heterocycles 2022, 104, 1469-1476. Link

38) Sbaraini N., Phan C.-S., et al. Intra-hemocoel injection of pseurotin A from Metarhizium anisopliae, induces dose-dependent reversible paralysis in the Greater Wax Moth (Galleria mellonella). Fungal Genet. Biol. 2022, 159, 103675. Link

37) Ishii T., Sato K., Ito G., Kawano J., Takabe W., Phan C.-S., et al. Unusual cembrane diterpenoid isolated from the Japanese soft coral genus Sinularia. Heterocycles 2022, 104, 797-803. Link

36) Phan C.-S.,† Matsuda K.,† et al. Argicyclamides A-C unveil enzymatic basis for guanidine bis-prenylation. J. Am. Chem. Soc. 2021, 143, 10083-10087. Link ; Patent PCT/JP2022/004501 ; Featured in Press Release

35) Sbaraini N., Hu J., Roux I., Phan C.-S., et al. Polyketides produced by the entomopathogenic fungus Metarhizium anisopliae induce Candida albicans growth. Fungal Genet. Biol. 2021, 152, 103568. Link

34) Li H., Glichrist C. L. M., Phan C.-S., et al. Biosynthesis of a new benzazepine alkaloid nanangelenin A from Aspergillus nanangensis involves an unusual L-kynurenine-incorporating NRPS catalyzing regioselective lactamization. J. Am. Chem. Soc. 2020, 142, 7145-7152. Link

33) Ng S.-Y., Phan C.-S., et al. Terpenoids from marine soft coral of the genus Xenia in 1977 to 2019. Molecules 2020, 25, 5386. Link

32) Phan C.-S., et al. Two new epimers of C15-acetogenin, 4-epi-isolaurallene and 4-epi-itomanallene A as diastereomeric model. Nat. Prod. Res. 2020, 34, 1008-1013. Link

31) Kamada T., Johanis M. L., Ng S.-Y., Phan C.-S., et al. A new epi-neoverrucosane-type diterpenoid from the liverwort Pleurozia subinflata in Borneo. Nat. Prod. Bioprospect. 2020, 10, 51-56. Link

30) Phan C.-S., et al. Bipolenins K–N: new sesquiterpenoids from the fungal plant pathogen Bipolaris sorokiniana. Beilstein J. Org. Chem. 2019, 15, 2020-2028. Link

29) Tani K., Kamada T., Phan C.-S., et al. New cembrane-type diterpenoids from Bornean soft coral Nephthea sp. with antifungal activity against Lagenidium thermophilum. Nat. Prod. Res. 2019, 33, 3343-3349. Link

28) Tani K., Kamada T., Phan C.-S., et al. A new bioactive cembranoid sarcophytonolide V from Bornean soft coral genus Sarcophyton. Nat. Prod. Commun. 2019, 14, 1-4. Link

27) Hamada T., Matsumoto Y., Phan C.-S., et al. Aaptamine-related alkaloid from the marine sponge Aaptos aaptos. Nat. Prod. Commun. 2019, 14, 1-3. Link

26) Kamada T., Phan C.-S., et al. Cytotoxicity and antibacterial potential of halogenated chamigrenes from Malaysian red alga, Laurencia majuscula. Planta Medica International Open 2019, 6, e36-e40. Link

25) Phan C.-S., et al. Cytotoxic sesquiterpenoids from soft coral Capnella imbricata. Nat. Prod. Commun. 2019, 14, 1-4. Link

24) Phan C.-S., et al. Sinulaflexiolide P, a cembrane-type diterpenoid from the Bornean soft coral Sinularia flexibilis. Chem. Nat. Comp. 2019, 55, 285-288. Link

23) Phan C.-S., et al. 12-Epi-9-deacetoxyxenicin, new cytotoxic diterpenoid from a Bornean soft coral, Xenia sp. Nat. Prod. Res. 2019, 33, 808-813. Link

22) Shamsudin K. J., Phan C.-S., et al. Leucoxenols A and B, two new phenolics from Bornean medicinal plant Syzygium leucoxylon. J. Asian Nat. Prod. Res. 2019, 21, 435-441. Link

21) Kamada T., Phan C.-S., et al. New anti-bacterial halogenated tricyclic sesquiterpenes from Bornean Laurencia majuscula (Harvey) Lucas. Nat. Prod. Res. 2019, 33, 464-471. Link

20) Kamada T., Phan C.-S., et al. Nangallenes A and B, halogenated nonterpenoid C15-acetogenins from the Bornean red alga Laurencia nangii. J. Asian Nat. Prod. Res. 2019, 21, 241-247. Link

19) Kamada T., Phan C.-S., et al. Neoiriepentaol and nangenyne, halogenated diterpenoid and C15-acetonenin from red alga Laurencia nangii Masuda collected in Borneo. J. Appl. Phycol. 2018, 30, 3379-3386. Link

18) Kamada T., Phan C.-S., et al. Halogenated chamigrane sesquiterpenes from Bornean Laurencia majuscula. J. Appl. Phycol. 2018, 30, 3373-3378. Link

17) Ng S.-Y., Kamada T., Phan C.-S., et al. New prenylated bibenzyls from Bornean liverwort Acrobolbus saccatus. Heterocycles 2018, 96, 1958-1965. Link

16) Phan C.-S., et al. Paralemnolins V and W, new nardosinane-type sesquiterpenoids from a Bornean soft coral, Lemnalia sp. Chem. Nat. Comp. 2018, 54, 903-906. Link

15) Kamada T., Kang M.-C., Phan C.-S., et al. Bioactive cembranoids from the soft coral genus Sinularia sp. in Borneo. Mar. Drugs 2018, 16, 99. Link

14) Phan C.-S., et al. Cytotoxic sesterterpenoids from Bornean sponge Spongia sp. Rec. Nat. Prod. 2018, 12, 643-647. Link

13) Phan C.-S., et al. 15-Deoxy-isoxeniolide-A, new diterpenoid from a Bornean soft coral, Xenia sp. Nat. Prod. Res. 2018, 32, 202-207. Link

12) Kamada T., Ng S.-Y., Phan C.-S., et al. Chemical composition and antibacterial activity of Bornean medicinal ginger Alpinia aquatica. Nat. Prod. Commun. 2018, 13, 741-742. Link

11) Hatai K., Kamada T., Lau L.-M., Kulip J., Phan C.-S., et al. In vitro inhibitory effects of two Bornean medicinal wild gingers against pathogenic Lagenidium thermophilum infected mud crab Scylla tranquebarica. Biocontrol Sci. 2018, 23, 35-39. Link

10) Kamada T., Zanil I. I., Phan C.-S., et al. A new cembrane, from soft coral genus Sarcophyton in Borneo. Nat. Prod. Commun. 2018, 13, 123-124. Link

9) Kamada T., Phan C.-S., et al. Cytotoxic and antifungal terpenoids from Bornean soft coral, Sinularia flexibilis. Nat. Prod. Commun. 2018, 13, 17-19. Link

8) Kamada T., Kulip J., Tani K., Phan C.-S., et al. Phillipsins A and B from Zingiber phillippsii Mood & Theilade in Borneo. Rec. Nat. Prod. 2018, 12, 317-322. Link

7) Ishii T., Kamada T., Phan C.-S., et al. Chabrolene, a novel norditerpene from the Bornean soft coral Nephthea sp. Sains Malays. 2018, 47, 319-322. Link

6) Phan C.-S., et al. A new guaiane-type sesquiterpenoid from a Bornean soft coral, Xenia stellifera. Nat. Prod. Commun. 2018, 13, 15-16. Link

5) Phan C.-S., et al. Capgermacrenes D-G, new sesquiterpenoids from a Bornean soft coral, Capnella imbricata. Nat. Prod. Res. 2017, 31, 742-748. Link

4) Ishii T., Phan C.-S., et al. Capgermacrene C, a new sesquiterpenoid from a Bornean soft coral, Capnella sp. Nat. Prod. Commun. 2016, 11, 1065-1066. Link

3) Phan C.-S., et al. Two new lobane diterpenes from a Bornean soft coral Sinularia sp. Nat. Prod. Commun. 2016, 11, 899-900. Link

2) Kamada T., Phan C.-S., et al. 16-Hydroxycembra-1,3,7,11-tetraene, a new cembrane diterpene from Malaysian soft coral genus Sarcophyton. Nat. Prod. Commun. 2016, 11, 1077-1078. Link

1) Phan C.-S., et al. Capgermacrenes A and B, bioactive secondary metabolites from a Bornean soft coral, Capnella sp. Mar. Drugs 2015, 13, 3103-3115. Link

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