Embedded Files
Google Scholar：Hui Hua Chang (張惠華)
學術成果 | Publications
學術成果 | Publications
A. 期刊論文 Journal Publications *corresponding author
A. 期刊論文 Journal Publications *corresponding author
Yang I-N†, Liang C-A†, Wu C-C, Xu Q-S, Lin S-W, Wang M-C, Chen M-J, Hsueh Y-S*, Chang HH *. Comprehensive surveillance of microRNA to discriminate between muscle-invasive and non-muscle-invasive urothelial carcinoma based on noninvasive urinary small RNA sequencing in Taiwanese patients. BMC cancer 2025 in press. (SCI) [IF: 3.4 Category: ONCOLOGY, Rank: 118/328=35.9%]
Wu C-Y, Chang C-Y, Wei S-Y, Chang HH, Tsai Y-T, Lu T-H, Lin R-Y, Yang Y-K, Chen PS, Huang Y-L, Tseng H-H*. Executive function mediates prefrontal excitation-inhibition balance and emotion recognition in euthymic bipolar disorder. Psychological Medicine 2025 Oct ; 55:e307~1- e307~7. (SCI) [IF: 5.5, Category: PSYCHOLOGY, CLINICAL, Rank: 7/185=3.7%]
Chang W-H, Lu T-H , Bui VS , Chang HH, Weng J-C , Lin S-H , Wei S-Y, Tseng H-H, Chen PS*. The associations between glucose, inflammation, cognitive functions, and white matter structural connectivity in euthymic bipolar patients. Brain Behavior and Immunity 2025 Nov; 130: 106109. (SCI) [IF: 7.6, Category: PSYCHIATRY, Rank: 11/288=3.8%]
Wei S.-Y., Tseng H.-H., Chang HH, Chen PS*: Pleiotropic effects of oxytocin receptor polymorphisms: influencing striatocortical connectivity in bipolar disorder. International Journal of Bipolar Disorders 2025 Aug;13:25. (SCI) [IF:3.5, Category: PSYCHIATRY, Rank: 71/288= 24.6%]
Chang Alice YW, Huang C.-W., Tsai P.-L., Liang C.-A., Liao WC, Fu T.-F., Chang HH*. Leveraging the enrichment analysis from a genome-wide association study against epilepsy – focusing on the role of tryptophan catabolites pathway in patients with drug-resistant epilepsy. Frontiers in Nutrition 2025 Aug; 12: doi.org/10.3389/fnut.2025.1539145. (SCI) [IF:5.1, Category: Nutrition & Dietetics, Rank: 16/112 =14.2%]
Wang T-Y*, Chang Y-H, Lee S-Y, Chang HH, Tsai T-Y, Tseng H-H, Wang S-M, Chen PS, Chen KC, Lee IH, Yang YK, Hong J-S, Lu R-B. Transdiagnostic features of inflammatory markers and executive function across psychiatric disorders. Journal of Psychiatric Research 2025 Jan; 181: 160-168. (SSCI) [IF: 3.7, Category: PSYCHIATRY, Rank: 63/279=22.6%]
Chang HH, Chang Alice YW, Tsai B-C, Chen Y-J, Wu S-G, Chen L-J, Lin Y-X, Hsueh Y-S*. Ethanol extract of Vanilla planifolia stems reduce PAK6 expression and induce cell death. Journal of Cellular and Molecular Medicine 2024 Sep; 28(17): e70065. (SCI) [IF:4.3, Category: Medicine, Research & Experimental, Rank: 58/189=30.7%]
Wang S-M, Chang HH, Chang Y-H, Tsai T-Y, Chen PS, Lu R-B, Wang T-Y*. Shortening of telomere length may be associated with inflammatory cytokine levels in patients with bipolar disorder. Journal of Affective Disorders 2024 Nov; 365:155-161. (SCI) [IF:4.9, Category: Clinical Neurology, Rank: 35/277=12.6%]
Tseng H-H, Wu CY, Chang HH, Lu T-H, Chang WH, Hsu C-F, Lin R-Y, Yeh D-R, Shaw F-Z, Yang YK, Chen PS*: Posterior cingulate and medial prefrontal excitation-inhibition balance in euthymic bipolar disorder. Psychological Medicine 2024 Jun; 3:1-9. (SSCI) [IF:6.9, Category: Psychology, Clinical, Rank: 10/131=7.6%]
Chang C-Y, Chang HH, Wu CY, Tsai YT, Lu T-H, Chang WH, Hsu C-F, Chen PS, Tseng H-H. Peripheral inflammation is associated with impaired sadness recognition in euthymic bipolar patients. Journal of Psychiatric Research 2024 May; 173:333-339. (SSCI) [IF:4.8, Category: Psychiatry, Rank: 39/144=27.1%]
Tsai T-H, Lu T-H, Tseng H-H, Chang WH, Wang T-Y, Yang YK, Chang HH, Chen PS*. The relationship between peripheral insulin resistance and social cognitive deficits among euthymic patients with bipolar disorder. Journal of Affective Disorders 2023 Dec; 1:342:121-126. (SCI) [IF: 6.600, Category: Clinical neurology, Rank: 23/212=10.8%]
Tsai YT, Chang C-Y, Wu CY, Huang Y-L, Chang HH, Lu T-H, Chang WH, Chiu N-T, Hsu C-F, Yang YK, Chen PS, Tseng H-H. Social cognitive deficit is associated with visuomotor coordination impairment and dopamine transporter availability in euthymic bipolar disorder. Journal of Psychiatric Research 2023 Sep; 165: 158-164. (SSCI) [IF: 4.800, Category: Psychiatry, Rank: 39/144=27.1%]
Wei S-Y, Tseng H-H, Chang HH, Chang, WH, Yang YK, Chen PS. Associations of leptin and corticostriatal connectivity in bipolar disorder. Scientific Report 2022 Dec; 12(1): 21898. (SCI) [IF: 4.997, Category: Multidisciplinary sciences, Rank: 19/74=25.7%]
Chang HH, Chang Y-Y, Tsai B-C, Chen L-J, Chang A-C, Chuang J-Y, Gean P-W* and Hsueh Y-S*. A Selective Histone Deacetylase Inhibitor Induces Autophagy and Cell Death via SCNN1A Downregulation in Glioblastoma Cells. Cancers 2022 Sep; 14(18): 4537. (SCI) [IF: 6.575, Category: Oncology, Rank: 60/245=24.5%]
Chang HH*, Hsueh Y-S, Cheng YW, Tseng H-H. A longitudinal study of the association between the LEPR polymorphism and treatment response in patients with bipolar disorder. International Journal of Molecular Sciences 2022 Aug; 23(17): 9635. (SCI) [IF: 6.208, Category: Biochemistry & molecular biology, Rank: 69/297=23.2%]
Hsu C-C*, Hsu Isabel, Lee L-H, Hsueh Y-S, Lin C-Y, Chang HH*. Intraovarian Injection of Recombinant Human Follicle-Stimulating Hormone for Luteal-Phase Ovarian Stimulation during Oocyte Retrieval Is Effective in Women with Impending Ovarian Failure and Diminished Ovarian Reserve. Biomedicines 2022 June; 10(6): 1312. (SCI) [IF: 6.081, Category: Pharmacology & pharmacy, Rank: 33/276=11.9%]
Tsai PL, Chang HH*, Chen PS. Predicting the treatment response to antidepressants using a deep neural network of deep learning in drug-naïve major depressive patients. Journal of Personalized Medicine 2022 Apr; 12(5): 693. (SCI) [IF: 4.945, Category: Health care sciences & services, Rank: 15/107=14.0%]
Hsu C-C*, Hsu Isabel, Lee L-H, Hsu Rosie, Hsueh Y-S, Lin C-Y, Chang HH*. Ovarian Follicular Growth through Intermittent Vaginal Gonadotropin Administration in Diminished Ovarian Reserve Women. Pharmaceutics 2022 Apr; 14(4): 869. (SCI) [IF: 6.321, Category: Pharmacology & pharmacy, Rank: 29/276=10.5%]
Chen PS, Tang L-Y, Chang HH*. Roles of CRP polymorphisms and life event changes on cognitive function in bipolar patients receiving valproate. International Journal of Immunopathology and Pharmacology 2022 Apr; 36: 1-14. (SCI) [IF: 3.219, Category: Pathology, Rank: 34/77=44.2%]
Chang C-C, Chen PS, Lin J-R, Chen Y-A, Liu C-S, Lin T-T, Chang HH*. Mitochondrial DNA copy number is associated with treatment response and cognitive function in euthymic bipolar patients receiving valproate. International Journal of Neuropsychopharmacology 2022 Aug; 25(7): 525-533. (SCI) [IF: 5.176, Category: Pharmacology & pharmacy, Rank: 58/276=21.0%]
Hsueh Y-S, Chang HH, Ko S-Y, Lin Y-P, Lin W-Y*. Differentially Expressed Genes Correlated with Fibrosis in a Rat Model of Chronic Partial Bladder Outlet Obstruction. Processes 2021 Dec; 9(12), 2219. (SCI) [IF: 2.847, Category: Engineering, chemical, Rank: 74/143=51.7%]
Lee CN, Huang Y-L, Chang HH, Kuo CY, Lu T-H, Hsieh Y-T, Chang WH, Yang YK, Chen PS, Tseng H-H*. Associations of emotion recognition, loneliness, and social functioning in euthymic patients with bipolar disorder. The Kaohsiung journal of medical sciences 2022 Jul; 38: 703-711. (SCI) [IF: 2.744, Category: Medicine, research & experimental, Rank: 93/140=66.4%]
Hsu C-C, Hsu Leonard, Hsueh Y-S, Lin C-Y, Chang HH*, Hsu CT. Ovarian folliculogenesis and uterine endometrial receptivity after intermittent vaginal injection of recombinant human follicle-stimulating hormone in infertile women receiving in vitro fertilization and in immature female rats. International Journal of Molecular Sciences 2021 Oct; 22(19): 10769. (SCI) [IF: 5.923, Category: Biochemistry & molecular biology, Rank: 67/297=22.6%]
Hsu CC*, Hsu Rosie, Chang HH, Hsu Isabel, Dorjee Sonam. Extended injection intervals of gonadotropins by intradermal administration in IVF treatment. Journal of Clinical Endocrinology & Metabolism 2021 Oct: 107(2):e716-e733. (SCI) [IF: 5.958, Category: Endocrinology & metabolism, Rank: 28/145=19.3%]
Liao W-C, Huang C-W, Hsiao Y-H, Sung P-S, Fu T-F, Chang Alice Y. W., Chang HH*. Association between the Serum Coenzyme Q10 Level and Seizure Control in Patients with Drug-Resistant Epilepsy. Healthcare 2021 Sep; 9(9): 1118. (SCI & SSCI) [IF: 2.645, Category: Health policy & services, Rank: 40/88=45.5%]
Chang HH, Tseng H-H, Chang WH, Huang K-C, Lu T-H, Yang YK, Chen PS*. Peripheral insulin sensitivity predicting cognitive function in euthymic bipolar disorder patients. CNS Spectrums 2021 Mar: 1-6. (SCI) [IF: 3.356, Category: Clinical neurology, Rank: 63/204=30.9%]
Hsueh Y-S, Lin C-Y, Chiu N-T, Yang YK, Chen PS*, Chang HH*. Changes in striatal dopamine transporters in bipolar disorder and valproate treatment. European Psychiatry 2021 Jan; 64(1): e9, 1-7. (SCI & SSCI) [IF: 4.464, Category: Psychiatry, Rank: 19/142=13.4%]
Hsieh Y-T, Wu R, Tseng H-H, Wei S-Y, Huang M-C, Chang HH, Yang YK, Chen PS*. Childhood neglect is associated with corticostriatal circuit dysfunction in bipolar disorder adults. Psychiatry Research 2021 Jan; 295:113550. (SCI & SSCI) [IF: 2.118, Category: Psychiatry, Rank: 65/142=45.8%]
Chen P-Y, Tsai Y-W, Chang Alice Y. W., Chang HH, Hsiao Y-H, Huang C-W, Sung P-S, Chen B-H, Fu T-F*. Increased leptin-b expression and metalloprotease expression contributed to the pyridoxine-associated toxicity in zebrafish larvae displaying seizure-like behavior. Biochemical Pharmacology 2020 Dec; 182:114294. (SCI) [IF: 4.960, Category: Pharmacology & pharmacy, Rank: 27/271=9.96%]
Liu YC, Tseng H-H*, Chang Y-H, Chang HH, Yang YK, Chen PS. The social cognitive ability in Han Chinese euthymic patients with bipolar I and bipolar II disorder. Journal of The Formosan Medical Association 2021 May; 120(5): 1221-1228. (SCI) [IF: 3.008, Category: Medicine, general & internal, Rank: 42/165=25.5%]
Tseng H-H, Chang HH, Wei S-Y, Lu T-H, Hsieh Y-T, Yang YK, Chen PS*. Peripheral inflammation is associated with dysfunctional corticostriatal circuitry and executive dysfunction in bipolar disorder patients. Brain Behavior and Immunity 2021 Jan; 91: 695-702. (SCI) [IF: 6.633, Category: Psychiatry, Rank: 14/155=9.03%]
Chang HH†, Sung P-S†, Liao WC, Chang Alice Y. W., Hsiao Y-H, Fu T-F, Huang C-Y and Huang C-W*. An open pilot study of the effect and tolerability of add-on multivitamin therapy in patients with intractable focal epilepsy. Nutrients 2020 Aug; 12(8):2359. (SCI) [IF: 4.546, Category: Nutrition & dietetics, Rank: 17/89=19.1%]
Wei S-Y, Tseng H-H, Chang HH, Lu T-H, Chang WH, Chiu NT, Yang YK, Chen PS*. Dysregulation of oxytocin and dopamine in the corticostriatal circuitry in bipolar II disorder. Translational Psychiatry 2020 Aug; 10:281.(SCI) [IF: 5.280, Category: Psychiatry, Rank: 21/155=13.5%]
Chang HH, Chen PS*. Inflammatory Biomarkers for Mood Disorders- A Brief Narrative Review. Current Pharmaceutical Design 2020 Jan; 26(2): 236-243. (SCI) [IF: 2.412, Category: Pharmacology & pharmacy, Rank: 148/267=55.4%]
Chang HH, Chang WH, Chi MH, Peng YH, Huang C-C, Yang YK, Chen PS*. The OXTR polymorphism stratified the correlation of oxytocin and glucose homeostasis in non-diabetic subjects. Diabetes Metabolic Syndrome and Obesity-Targets and Therapy 2019 Dec; 12: 2707-2713. (SCI) [IF: 3.319, Category: Endocrinology & metabolism, Rank: 62/145=42.8%]
Tsai T-Y, Tseng H-H, Chi MH, Chang HH, Wu C-K, Yang YK, Chen PS*. The Interaction of Oxytocin and Social Support, Loneliness, and Cortisol Level in Major Depression. Clinical Psychopharmacology and Neuroscience 2019 Nov; 17(4): 487-494. (SCI) [IF: 2.470, Category: Pharmacology & pharmacy, Rank: 139/267=52.1%]
Hsueh Y-S, Chang HH, Shan Y-S, Sun H. S, Fletcher J A, Li C-F*, Chen L-T*. Nuclear KIT induces a NFKBIB-RELA-KIT autoregulatory loop in imatinib-resistant gastrointestinal stromal tumors. Oncogene 2019 Sep; 38(38): 6550–6565. (SCI) [IF: 6.634, Category: Genetics & heredity, Rank: 15/174=8.62%]
Chang HH*, Hsueh Y-S, Cheng YW, Ou HT, Wu MH. Association between polymorphisms of OCT1 and metabolic response to metformin in women with polycystic ovary syndrome. International Journal of Molecular Sciences 2019 Jan; 20(7): 1720. (SCI) [IF: 3.687, Category: Chemistry, multidisciplinary, Rank: 52/171=30.4%]
Lee CJ, Lee LT, Tsai HC, Chang WH, Lee IH, Chen KC, Chang HH, Chen PS, Yang YK. Factors related to metabolic parameters in medicated patients with major depressive disorder––a naturalistic study. Psychiatry Research 2018 Oct; 268: 28-33. (SSCI & SCI) [IF: 2.223, Category: Psychiatry, Rank: 61/142=43.0%]
Lien Y-J, Chang HH, Tsai H-C, Yang YK, Lu R-B, Chen PS*. Plasma oxytocin levels in major depressive and bipolar II disorders. Psychiatry Research 2017 Dec; 258:402-406. (SSCI & SCI) [IF: 2.528, Category: Psychiatry, Rank: 46/139=33.1%]
Chang HH*, Chen PS*, Cheng YW, Wang T-Y, Yang YK, Lu R-B. FGF21 is Associated with Metabolic Effects and Treatment Response in Depressed Bipolar II Disorder Patients Treated with Valproate. International Journal of Neuropsychopharmacology 2018 Apr; 21(4): 319-324. (SCI) [IF: 4.712, Category: Pharmacology & pharmacy, Rank: 29/257=11.3%]
Chen W-C, Wang W-C, Okada Yukinori, Chang W-P, Chou Y-H, Chang HH, Huang J-D, Chen D-Y, and Chang W-C *. rs2841277 (PLD4) is associated with susceptibility and rs4672495 is associated with disease activity in rheumatoid arthritis. Oncotarget. 2017 Jul; 8(38): 64180–64190. (SCI) [IF: 5.168, Category: Oncology, Rank: 44/217=20.3%]
Chang HH*, Chen PS. C-reactive protein as a differential biomarker of bipolar versus unipolar depression: Response. The World Journal of Biological Psychiatry 2017 Feb; 18(1):73-74 (SCI) [IF: 4.159, Category: Psychiatry, Rank: 29/142=20.4%]
Chang HH, Chen PS*, Wang TY, Lee SY, Chen SL, Huang SY, Hong JS, Yang YK, Lu R-B: Effect of memantine on C-reactive protein and lipid profiles in bipolar disorder. Journal of Affective Disorders 2017 Oct 9;221:151-57 (SCI&SSCI) [IF: 3.432, Category: Psychiatry, Rank: 26/139=18.7%]
Chen PS*, Chang HH*, Huang C-C, Lee CC, Lee S-Y, Chen S-L, Huang S-Y, Yang YK, Lu R-B: A longitudinal study of the association between the GNB3 C825T polymorphism and metabolic disturbance in bipolar II patients treated with valproate. Pharmacogenomics Journal 2017 Mar;17(2):155-61 (SCI) [IF: 3.784, Category: Pharmacology & pharmacy, Rank: 52/255=20.4%]
Chang HH, Wang T-Y, Lee IH, Lee S-Y, Chen KC, Huang S-Y, Yang YK, Lu R-B, Chen PS*: C-reactive protein: a differential biomarker for major depressive disorder and bipolar II disorder. World Journal of Biological Psychiatry 2017 Feb;18(1):63-70 (SCI) [IF: 4.159, Category: Psychiatry, Rank: 29/142=20.4%]
Chang HH, Chou C-H, Yang YK, Lee IH, Chen PS*: Association between ABCB1 Polymorphisms and Antidepressant Treatment Response in Taiwanese Major Depressive Patients. Clinical Psychopharmacology and Neuroscience 2015 Dec;13(3):250-5 (SCI) [IF: 1.500, Category: Pharmacology & pharmacy, Rank: 193/255=75.7%]
Wang T-Y, Chang HH, Ke W-M, Chou C-H, Lee L-T, Yang YK, Lu R-B, Chen PS*: Correlation between Cytochrome P450 2D6 Genotype and Methadone Concentration-to-dose Ratio. Taiwanese Journal of Psychiatry (Taipei) 2015 Sep;29(3):180-90
Tsai HC, Lin S-H, Chen PS, Chang HH, Lee IH, Yeh TL, Chen KC, Chiu NT, Yao WJ, Liao M-H, Yang YK*: Quantifying midbrain serotonin transporter in depression: a preliminary study of diagnosis and naturalistic treatment outcome. Pharmacopsychiatry 2015 Mar;48(2):58-64 (SCI) [IF: 2.168, Category: Psychiatry, Rank: 67/136=49.3%]
Hsueh YS, Chang HH, Chiang NJ, Yen CC, Li CF*, Chen LT*: MTOR inhibition enhances NVP-AUY922-induced autophagy-mediated KIT degradation and cytotoxicity in imatinib-resistant gastrointestinal stromal tumors. Oncotarget 2014 Nov 30;5(22):11723-36 (SCI) [IF: 6.627, Category: Oncology, Rank: 17/203=8.4%]
Lin YH*, Fang MC, Chang HH: A Searching Technique for Obstacle-Avoidance of Autonomous Underwater Vehicles by Using the Self-Tuning Fuzzy Controller. Proceedings of American Society of Mechanical Engineers, 2014 Jun; V007T12A022-30 (EI)
Chang HH, Chi MH, Lee IH, Tsai HC, Gean PW, Yang YK, Lu RB, Chen PS*: The change of insulin levels after six weeks antidepressant use in drug-naïve major depressive patients. Journal of Affective Disorders 2013 Sep;150(2):295-9 (SCI&SSCI) [IF: 3.295, Category: Psychiatry, Rank: 23/121=19.0%]
Chang HH, Chen PS*, Wang HC, Gean PW, Yang YK, Lu RB: Interaction between CYP 2C19 and CYP 2D6 genetic polymorphisms and fluoxetine/ venlafaxine treatment response in Taiwanese major depressive patients. Taiwanese Journal of Psychiatry (Taipei) 2013 Sep;27(3):216-27
Chang WH, Chen WT, Chang HH, Chen KC, Lee IH, Yeh TL, Chen PS, Lee L-T*, Yang YK: Fasting serum glucose level in unmedicated patients with major depressive disorder. Taiwanese Journal of Psychiatry (Taipei) 2013 Jun;27(2):140-7
Chi MH, Chang HH, Tzeng NS, Huang SY, Chou KR, Tsai HC, Yang YK, Lu RB, Chen PS*: The prevalence of metabolic syndrome in drug-naïve bipolar II disorder patients before and after twelve-week pharmacological intervention. Journal of Affective Disorders 2013 Mar;146(1):79-83 (SCI&SSCI) [IF: 3.517, Category: Psychiatry, Rank: 19/117=16.2%]
Chang HH, Lee IH, Gean PW, Lee SY, Chi MH, Yang YK, Lu RB, Chen PS*: Treatment response and cognitive impairment in major depression: Association with C-reactive protein. Brain, Behavior, and Immunity 2012 Jan;26(1):90-5 (SCI) [IF: 3.956, Category: Immunology, Rank: 35/134=26.1%]
Chi MH, Lee SY, Chang HH, Yang YK, Eugene Lin, Chen PS*: Comparison of Antidepressant Efficacy-related SNPs Among Taiwanese and Four Populations in the HapMap Database. Journal of the Formosan Medical Association. 2011 Jul;110(7):478-82 (SCI) [IF: 1.125, Category: Medicine, general & internal, Rank: 76/153=49.7%]
Wang HC, Yeh TL, Chang HH, Gean PW, Chi MH, Yang YK, Lu RB, Chen PS*: TPH1 is Associated with Major Depressive Disorder but Not with SSRI/SNRI Response in Taiwanese Patients. Psychopharmacology (Berl) 2011 Feb;213(4):773-9 (SCI) [IF: 4.103, Category: Pharmacology & pharmacy, Rank: 36/237=15.2%]
Chi MH, Chang HH, Lee SY, Lee IH, Gean PW, Yang YK, Lu RB, Chen PS*: Brain derived neurotrophic factor gene polymorphism (Val66Met) and short-term antidepressant response in major depressive disorder. Journal of Affective Disorders 2010 Nov;126(3):430-5 (SCI&SSCI) [IF: 3.763, Category: Psychiatry, Rank: 14/94=14.9%]
Chang HH, Gean PW, Chou CH, Yang YK, Tsai HC, Lu RB, Chen PS*: C825T polymorphism of the GNB3 gene on valproate-related metabolic abnormalities in bipolar disorder patients. Journal of Clinical Psychopharmacology 2010 Oct;30(5):512-7 (SCI) [IF: 5.092, Category: Pharmacology & pharmacy, Rank: 20/237=8.4%]
Chi MH, Chang HH, Chen PS*: Oseltamivir-related Derealization and Depersonalization Experiences. Taiwanese Journal of Psychiatry (Taipei) 2010 Sep;24(3):232-5
Chang HH, Yang YK, Gean PW, Huang HC, Chen PS*, Lu RB: The role of valproate in metabolic disturbances in bipolar disorder patients. Journal of Affective Disorder 2010 Aug;124(3):319-23 (SCI&SSCI) [IF: 3.763, Category: Psychiatry, Rank: 14/94=14.9%]
Eugene Lin, Chen PS*, Lee IH, Chang HH, Gean PW, Yang YK, Lu RB: Modeling Short-Term Antidepressant Responsiveness with Artificial Neural Networks. Open Access Bioinformatics 2010 Jun;2:55-60
Chang HH, Lee NY, Ko WC, Lee HC, Yang YH, Wu CJ, Chang CM: Voriconazole Inhibition of Tacrolimus Metabolism in a Kidney Transplant Recipient with Fluconazole-Resistant Cryptococcal Meningitis. International Journal of Infectious Diseases 2010 Apr;14(4):e348-50 (SCI) [IF: 2.210, Category: Infectious diseases, Rank: 32/51=62.7%]
Eugene Lin, Chen PS*, Chang HH, Gean PW, Tsai HC, Yang YK, Lu RB: Interaction of serotonin-related genes affects short-term antidepressant response in major depressive disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2009 Oct;33(7):1167-72 (SCI) [IF: 2.638, Category: Clinical neurology, Rank: 55/156=35.3%]
Chang HH, Chou CH, Chen PS*, Gean PW, Huang HC, Lin CY, Yang YK, Lu RB: High Prevalence of Metabolic Disturbances in Patients with Bipolar disorder in Taiwan. Journal of Affective Disorders 2009 Sep;117(1-2):124-9 (SCI&SSCI) [IF: 3.271, Category: Psychiatry, Rank: 19/86=22.1%]
Chang HH, Cheng MF, Liu HL, Lee RS, Kao Yang YH, Huang JJ: Acute Spontaneous Spinal Epidural Hematoma in a Hemodialysis Patient: A Case Report. Acta Nephrologica 2007 Jun;21(2):150-53
<註記：Impact factor (IF)與學門Rank以期刊發表當年度標示之，以中立清楚呈現發表之研究成果。>
B. 研討會論文 Conference Papers
B. 研討會論文 Conference Papers
Yuan-Shuo Hsueh, Chun-An Liang, I-Ning Yang, Qian-Sheng Xu, Hui Hua Chang*. Profiling Urinary MicroRNAs as Potential Non-Invasive Diagnostic Tools for Urothelial Carcinoma in Taiwanese Patients. Poster presented at 17th Congress of the European Association for Clinical Pharmacology and Therapeutics (EACPT 2025), Helsinki, Finland, 28 June – 1 July, 2025.
Hui Hua Chang*, Ping Lin Tsai, Wan Zheng Teoh, Po See Chen. Integration of polygenic risk score and microbial risk score to predict disease risk and treatment outcome in bipolar disorder patients. Poster presented at 17th Congress of the European Association for Clinical Pharmacology and Therapeutics (EACPT 2025), Helsinki, Finland, 28 June – 1 July, 2025.
Ping Lin Tsai, Hong-Wen Wang, Alice Y. W. Chang, Yuan-Shuo Hsueh, Hui Hua Chang*. Identifying Parkinson's Disease-Associated Genes via a Genome-Wide Association Study of Taiwanese Population and a Cell Model. Oral presented at 17th Congress of the European Association for Clinical Pharmacology and Therapeutics (EACPT 2025), Helsinki, Finland, 28 June – 1 July, 2025.
Yuan-Shuo Hsueh, Chun-An Liang, I-Ning Yang, Qian-Sheng Xu, Hui Hua Chang*. Profiling Urinary MicroRNAs as Potential Non-Invasive Diagnostic Tools for Urothelial Carcinoma in Taiwanese Patients. Poster presented at 17th Congress of the European Association for Clinical Pharmacology and Therapeutics (EACPT 2025), Helsinki, Finland, 28 June – 1 July, 2025.
Hui Hua Chang*, Ping Lin Tsai, Wan Zheng Teoh, Po See Chen. Integration of polygenic risk score and microbial risk score to predict disease risk and treatment outcome in bipolar disorder patients. Poster presented at 17th Congress of the European Association for Clinical Pharmacology and Therapeutics (EACPT 2025), Helsinki, Finland, 28 June – 1 July, 2025.
Ping Lin Tsai, Hong-Wen Wang, Alice Y. W. Chang, Yuan-Shuo Hsueh, Hui Hua Chang*. Identifying Parkinson's Disease-Associated Genes via a Genome-Wide Association Study of Taiwanese Population and a Cell Model. Oral presented at 17th Congress of the European Association for Clinical Pharmacology and Therapeutics (EACPT 2025), Helsinki, Finland, 28 June – 1 July, 2025.
Hsin Yang, Cong-Yuan Dai, Yang-Kuang Lin, Hui-Hsin Xue, Yuu-Yun Mo, Shiou-Chi Li, Shang-Chun Lu, Jen-Wei Huang, Hui Hua Chang and Wei-Sheng Wu. A Trustworthy Medication AI Clinician by Multi-aspect Retrieval-Augmented Generators. Poster presented at 28th European Conference on Artificial Intelligence (ECAI-2025), Bologna, Italian, 25-30 October, 2025.
Tsai P-L, Chang HH*. Utilizing network-based algorithms for drug repurposing through a meta-analysis of east asian genome-wide association studies in depression. Poster presented at The Federation of European Neuroscience Societies (FENS) 2024, Vienna, Austria, 25-29 June 2024.
Chang HH, Tsai B-C, Lin Y-X, Hsueh Y-S. Ethanol extract of vanilla planifolia stem reduced PAK6 expression and induced cell death in glioblastoma cells. Poster presented at The Federation of European Neuroscience Societies (FENS) 2024, Vienna, Austria, 25-29 June 2024.
Tsai P-L Hsueh Y-S, Chang HH*. Leveraging Pharmacogenomic Enrichment Score to Predict Treatment Outcomes in Drug-Naïve Patients with Major Depressive Disorder. Poster presented at The Federation of European Neuroscience Societies (FENS) 2024, Vienna, Austria, 25-29 June 2024.
Chang HH*, Hsueh YS, Chiu CH. Polygenic risk score is associated with treatment response in patients with bipolar disorder. Poster presented at 19th World Congress of Basic & Clinical Pharmacology (WCP2023), Glasgow, Scotland, 2-7 Jul 2023.
Chiu CH, Chang HH*. Causal effect of Fibroblast growth factor-2 on Bipolar risk: A Mendelian randomization analysis. Slide presented at 2022 The 33rd CINP Hybrid World Congress of Neuropsychopharmacology, Virtual & Taipei, Taiwan, Jun 9-13, 2022.
Tsai PL, Chang HH*. Predicting the treatment outcome of antidepressants using deep learning against major depressive disorder. Slide presented at 2022 The 33rd CINP Hybrid World Congress of Neuropsychopharmacology, Virtual & Taipei, Taiwan, Jun 9-13, 2022.
Chiu CH, Chang HH*. Identification of risk loci and functional enrichment analysis from genome–wide association study against bipolar disorder. Slide presented at 2021 The 3rd Taiwan Joint Conference of Pharmacy and Pharmaceutical Sciences – Advancing with AI technology through the pandemic, Tainan, Taiwan, Nov 6-7, 2021.
Tsai PL, Chang HH*. Predicting the treatment outcome of antidepressants using deep learning against major depressive disorder. Slide presented at 2021 The 3rd Taiwan Joint Conference of Pharmacy and Pharmaceutical Sciences – Advancing with AI technology through the pandemic, Tainan, Taiwan, Nov 6-7, 2021.
黃苡禎、周冠玗、何惠如、張惠華、蕭潔君、許美英。PGY精神科聯合訓練初探。Slide presented at 2021 The 3rd Taiwan Joint Conference of Pharmacy and Pharmaceutical Sciences – Advancing with AI technology through the pandemic, Tainan, Taiwan, Nov 6-7, 2021.
徐宛琳、張惠華、戴淑華、鄭靜蘭。探討南部醫學中心肺炎鏈球菌疫苗使用趨勢與Covid-19疫情變化關係。Slide presented at 2021 The 3rd Taiwan Joint Conference of Pharmacy and Pharmaceutical Sciences – Advancing with AI technology through the pandemic, Tainan, Taiwan, Nov 6-7, 2021.
Lin J-R, Chang HH*, Chen PS. Polymorphisms of inflammatory cytokine genes on cognitive function and treatment response in bipolar disorder. Slide presented at CINP 2021 VIRTUAL WORLD CONGRESS, Taipei, Taiwan, Feb 26-28, 2021.
Chen Y-A, Chang HH*, Chen PS. Association between fibroblast growth factor-2 and cognitive function in euthymic bipolar patients with valproate. Slide presented at CINP 2021 VIRTUAL WORLD CONGRESS, Taipei, Taiwan, Feb 26-28, 2021.
Lin J-R, Chang HH*, Chen PS. Mitochondrial DNA variation and cognitive function in bipolar patients receiving valproate. Poster presented at 2020 Annual Conference of The Pharmaceutical Society of Taiwan, Taipei, Taiwan, Nov 8, 2020.
Lin C-Y, Hsueh Y-S, Chang HH*. Gut microbiota modulated VPA-induced dyslipidemia in social defeat stress mouse model. Poster presented at 2020 12th the Federation of European Neuroscience Societies (FENS) forum of neuroscience, Glasgow, Scotland, UK, Jul 11-15, 2020.
Liao WC, Sung P-S, Huang C-W, Chang HH*. Identified risk loci from genome-wide association analysis and biological pathways in epilepsy. Poster presented at 2020 12th the Federation of European Neuroscience Societies (FENS) forum of neuroscience, Glasgow, Scotland, UK, Jul 11-15, 2020.
Chen Y-A, Chang HH*, Chen PS. Gut microbiota and its association with inflammation in euthymic bipolar patients with long-term use of valproate. Poster presented at 2020 12th the Federation of European Neuroscience Societies (FENS) forum of neuroscience, Glasgow, Scotland, UK, Jul 11-15, 2020.
Chang HH*, Lin C-Y, Chen PS. Altered level of striatal dopamine transporter in bipolar disorder and valproate treatment. Poster presented at the Society of Biological Psychiatry's 75th Annual Scientific Program and Convention, New York, USA, Apr 30-May 02, 2020.
Lin C-Y, Hsueh Y-S, Chang HH*. Alternation of the effects of valproic acid on striatal dopamine transporter in social defeat stress mouse model. Poster presented at 2019 Annual Conference of The Pharmaceutical Society of Taiwan, Taipei, Taiwan, Dec 14, 2019.
Liao WC, Chang HH*. Genome-wide association analyses of epilepsy from Taiwan Biobank. Poster presented at 2019 Annual Conference of The Pharmaceutical Society of Taiwan, Taipei, Taiwan, Dec 14, 2019. (Merit Award)
Chen Y-A, Chang HH*, Chen PS. Associations between fibroblast growth factor-2 and cognitive function in patients with bipolar disorder and major depression. Poster presented at 2019 Annual Conference of The Pharmaceutical Society of Taiwan, Taipei, Taiwan, Dec 14, 2019. (Merit Award)
Liao WC, Chang HH*. Genome-wide association analyses of epilepsy from Taiwan Biobank. Poster presented at 2019 Symposium of Taiwan Society for Biopreservation and Biobanking, Taipei, Taiwan, Dec 16 – 17, 2019.
Chang HH*, Tang L-Y, and Chen PS. Is C-reactive protein level a causal factor in risk of bipolar disorder? A mendelian randomization study. Poster presented at the 27th European Congress of Psychiatry (EPA 2019), Warsaw, Poland, Apr 06 - 09, 2019.
Chang HH*. Influence of C-reactive protein and psychosocial stress on risk of bipolar disorder and cognitive function in bipolar Patients. Oral presented at WFSBP Asia Pacific Regional Congress of Biological Psychiatry, Kobe, Japan, Sept 7- 9, 2018.
Hsieh Y-T, Tseng HH, Lee L-T, Chang HH, Chi MH, Chang WH, Chen PS: The cognitive effect of childhood trauma in bipolar II disorders in euthymic state. Poster presented at IACAPAP 2018 Congress, Prague, Czech Republic, July 23-27 2018
Nu Henry, Chang HH*, and Chen PS*. Genome-wide association approach to major depressive disorder’s different Treatment Outcome. Poster presented at TIGP 2018, Taipei, Taiwan, Jul 27, 2018.
Chang HH and Chen PS*.The interaction of oxytocin and social support is associated with loneliness and cortisol level in major depression. Poster presented at 25th International ”Stress and Behavior” Neuroscience and Biopsychiatry Conference, St. Petersburg, Russia, May 16-19, 2018.
Tang L-Y and Chang HH*. Correlations between C-reactive protein, recent life events stress, and cognitive function in patients with bipolar disorder. Poster presented at 25th International ”Stress and Behavior” Neuroscience and Biopsychiatry Conference, St. Petersburg, Russia, May 16-19, 2018.
Chang HH* and Chen PS. Interactions of social stress and CRP gene polymorphism on treatment outcome in patients with major depressive disorder. Poster presented at 25th International ”Stress and Behavior” Neuroscience and Biopsychiatry Conference, St. Petersburg, Russia, May 16-19, 2018.
Yakimenko Olga, Chang HH*, Chen PS. Altered gut microbiota composition in mice and BD patients receiving VPA treatment. Poster presented at TIGP 2017, Taipei, Taiwan, Jul 31, 2017.
Chang HH*, Chen PS. Social stress and polymorphisms of CRP gene influence antidepressant treatment outcome in major depressive patients. Poster presented at CINP Thematic Meeting on Treatment Resistant Depression, Prague, Czech, Jul 20-22, 2017.
Cheng YW, Chang HH*, Chen PS: Association between the LEPR and valproate-related metabolic disturbances in bipolar patients. Oral presented at 2016 Annual Conference of The Pharmaceutical Science of Taiwan, Taipei, Taiwan, Dec 17, 2016.
Chang HH*. C-reactive protein: A differential biomarker for major depressive disorder and bipolar II disorder. Oral presented at 17th Pacific Rim College of Psychiatrists Scientific Meeting (PRCP), Kaohsiung, Taiwan, Nov 3-5, 2016.
Chang HH*, Cheng YW, Gean PW, Chen PS: The correlation between FGF-21 and metabolic effect in patients with bipolar disorder. Poster presented at 76th FIP World Congress of Pharmacy and Pharmaceutical Sciences, Buenos Aires, Argentina, 28 Aug - 1 Sep, 2016.
Chang HH*, Peng Y-C, Chen PS: The correlation between leptin, treatment response, and metabolic effect in major depressive disorder. Poster presented at the Society of Biological Psychiatry's 71th Annual Scientific Program and Convention, Atlanta, USA, May 14-16, 2016.
Chang HH*, Chen PS, Wang T-Y, Lee S-Y, Chen S-L, Huang S-Y, Yang YK, Lu R-B: The Metabolic Effect of Memantine on Bipolar II Disorder: The Role of the Baseline C-reactive Protein Level. Oral presented at 2015 world psychiatric association international congress of psychiatry (WPAIC), Taipei, Taiwan, Nov 22, 2015.
Chen Y-W, Chang HH, Chen PS: The Association of GNB3 Polymorphism and Cognitive Function in Patients with Bipolar II Disorder. Poster presented at the Society of Biological Psychiatry's 70th Annual Scientific Program and Convention, Toronto, Canada, May 14-16, 2015.
Chang HH*, Lee C-C, Chang WH, Chen PS: The polymorphisms of IGSF21 and glucose-insulin homeostasis in patients with major depressive disorder. Poster presented at the Society of Biological Psychiatry's 70th Annual Scientific Program and Convention, Toronto, Canada, May 14-16, 2015.
Hsueh Y-S, Chang HH, Yen C-C, Chiang N-J, Li C-F, Chen L-T: mTOR inhibition enhances NVP-AUY922-induced autophagy-meditated KIT degradation and tumor growth in imatinib-resistant gastrointestinal stromal tumors. Oral presented at 17th World Congress of Basic and Clinical Pharmacology, Cape Town, South Africa, Jul 13-18, 2014.
Chang HH, Chang WH, Chen PS: Association between the polymorphisms of OXTR and HbA1c in major depressive patients treated with antidepressant. Poster presented at 17th World Congress of Basic and Clinical Pharmacology, Cape Town, South Africa, Jul 13-18, 2014.
Hsueh Y-S, Chang HH, Yen C-C, Chiang N-J, Li C-F, Chen L-T: Combination of NVP-AUY922 with Rapamycin Enhances Autoghagy-mediated KIT Degradation and Cell Deaths in Imatinib-resistant Gastrointestinal Stromal Tumors. The 11th International Conference of the Asian Clinical Oncology Society, Taipei, Taiwan, May 2-4, 2014.
Chang HH, Yang YK, Chen PS: Association of GNB3 Gene polymorphism (C825T) on Vaplroate-Related Metabolic Abnormalities in Patients with Bipolar Disorder Ⅱ. Poster presented at the 7th Biennial Congress of The International Society for Affective Disorders, Berlin, German, Apr 28-30, 2014
Lin YH, Fang MC, Chang HH: The Ship-Routing Optimization based on the Three-Dimensional Modified Isochrone Method. Proceedings of the 32rd International OMAE, Nantes, France, Jun 8-14, 2013
Chang HH, Lin S-H, Chen PS, Yang YK: The Association between Social Support and Response of SSRI/SNRI Treatment in Patient with Major Depressive Disorder. Poster presented at the Society of Biological Psychiatry's 68th Annual Scientific Program and Convention, San Francisco, USA, May 3-5, 2013
Chang HH, Gean P-W, Chen PS, Kathleen M. Giacomini: A Neural Network Model for Predicting Treatment Response of Antidepressants in Patients with Major Depressive Disorder. Poster presented at the Society of Biological Psychiatry's 67rd Annual Scientific Program and Convention, Philadelphia, USA, May 3-5, 2012
Wang H-C, Chen PS, Chang HH, Gean P-W, Yang YK, Lu R-B: CYP2C19 Genetic Polymorphisms Influence Antidepressant Treatment Response in a Taiwanese Population with Major Depressive Disorder. Poster presented at the Society of Biological Psychiatry's 66rd Annual Scientific Program and Convention, San Francisco, USA, May 12-14, 2011
Chang HH, Gean P-W, Yang YK, Lu R-B, Chen PS: Association between ABCB1 polymorphisms and fluoxetine/venlafaxine treatment response in Taiwanese major depressive patients. Poster presented at the Society of Biological Psychiatry's 66rd Annual Scientific Program and Convention, San Francisco, USA, May 12-14, 2011
Chang HH, Gean P-W, Chen PS: The Effect of C825T Polymorphism of the GNB3 Gene on Valproate-Induced Metabolic Abnormalities in Bipolar Disorder Patients. Poster presented at the 16th World Congress on Basic and Clinical Pharmacology (IUPHAR), Copenhagen, Denmark, Jul 17-23, 2010
Chi M-H, Chang HH, Lee S-Y, Lee IH, Gean P-W, Yang YK, Chen PS, Lu R-B: Brain Derived Neurotrophic Factor Gene Polymorphism (Val66Met) and Short-Term Treatment Response to Fluoxetine or Venlafaxine in Major Depressive Disorder. Poster presented at the International College of Neuropsychopharmacology 27th biennial meeting, Hong Kong, Jun 6-10, 2010
Chang HH, Gean P-W, Yang YK, Lu R-B, Chen PS: Raised C-Reactive Protein Levels Associated With Antidepressant Treatment in Major Depressive Patients. Poster presented at the 27th biennial meeting of the International College of Neuropsychopharmacology, Hong Kong, Jun 6-10, 2010
Chen PS, Ke W-M, Chang HH, Hsu M-Y, Chou CH, Lu R-B: Cytochrome P450 2D6 Genotype and Methadone Concentration-to-Dose Ratio in Patients Receiving Methadone Maintenance Therapy in Taiwan. Poster presented at International Symposium in Substances Abuse meeting, Taiwan, May 13-14, 2010
Chang HH, Yang YK, Gean P-W, Huang HC, Chen PS, Lu R-B: Reduced Risk of Metabolic Disturbances in Drug Free Bipolar Patients. Poster presented at the 48th Annual Meeting of Taiwanese Society of Psychiatry, Taipei, Taiwan, Dec 2009
Eugene Lin, Chang HH, Gean P-W, Tsai HC, Chen PS: Interactions of serotonin-related genes with short-term antidepressant response in major depressive disorders. Poster presented at the American Psychiatry Association Annual Meeting, May 16-21, 2009, San Francisco, USA
Chang HH, Chen PS, Gean P-W: TPH1 is associated with major depressive disorder and fluoxetine treatment response in Taiwanese patients. Poster presented at the American Psychiatry Association Annual Meeting, May 16-21, 2009, San Francisco, USA
Chen PS, Chang C-W, Chang HH, Lu R-B, Gean P-W. The Association between a G-protein β3 Subunit Genetic Variation and Mood Stabilizers induced Metabolism Abnormalities in Bipolar Disorder Patients. Poster presented at the Society of Biological Psychiatry's 63rd Annual Scientific Program and Convention, May 1-3, 2008, Washington DC, USA
Chang C-W, Chang HH, Chen PS, Gean P-W: The Association Between Leptin Receptor Gene Polymorphisms and Mood Stabilizers Induced Metabolism Abnormalities in Patients with Bipolar Disorder. Poster presented at the Society of Biological Psychiatry's 63rd Annual Scientific Program and Convention, May 1-3, 2008, Washington DC, USA
Chang HH, Chen PS, Lu R-B, Gean P-W: Effects of Lithium and Valproate on Metabolic indexes in Taiwanese Bipolar Patients. Poster presented at the Society of Biological Psychiatry's 63rd Annual Scientific Program and Convention, May 1-3, 2008, Washington DC, USA
Chang HH, Chen PS, Lin CY, Chou CH, Yang YK, Lu R-B: Effects of Lithium and Valproate on Blood Sugar, Blood Lipid, and Body Weight in Bipolar Patients. Poster presented at the 46th Annual Meeting of Taiwanese Society of Psychiatry, Kaohsiung, Taiwan, Dec 2007
Chang HH, Wu Y-X, Kao Yang YH: Clozapine-induced diabetes ketoacidosis. Poster presented at the Pharmaceutical Society of Taiwan 2005 Annual Meeting, Taichung, Taiwan, Dec 2006
*張惠華、鄭詠文。聚焦個體化醫療:以藥物基因學、藥物動力學及藥效學應用入門 (Pharmacogenetics, Kinetics, and Dynamics for Personalized Medicine)。合記圖書出版社， 2020。 (ISBN: 9789863682875) (翻譯著作)
聚焦個體化醫療:以藥物基因學、藥物動力學及藥效學應用入門
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