SIGNOR

SIGNOR 4.0, The SIGnaling Network Open Resource, is a collection of manually curated causal relationships between biological entities such as human proteins, chemicals, stimuli, complexes, protein families etc. (Lo Surdo et al, 2025) 

The data in SIGNOR can be displayed as a signed, directed graph, representing the activation/inactivation relationships between signaling entities.  

The tools offered by the resource allow the user to enrich the annotated data and access a list of manually curated pathways.

Visit SIGNOR at https://signor.uniroma2.it

PhosphoSIGNOR, a dedicated user interface designed to enable targeted access to phosphorylation-specific information and network visualization. This expanded dataset allows for a more comprehensive mapping of signaling alterations and their associations with dysregulated cellular processes. 

The platform enables users to dynamically query phosphosite-specific data, examine context-dependent modifications, and integrate findings with known regulatory mechanisms.

Visit PhosphoSIGNOR at https://signor.uniroma2.it/PhosphoSIGNOR/