PUBLICATIONS
2024
Positional obstructive sleep apnea and periodic limb movement during sleep: A large multi-center study. Clinical and Experimental Otorhinolaryngology (accepted, corresponding)
2023
Analyzing the Impact of Body Position Shift on Sleep Architecture and Stage Transition: A Comprehensive Multidimensional Study Using Event-Synchronized Polysomnography Data. Journal of Sleep Research (accepted, corresponding, IF=5.3)
Neutrophil extracellular traps promote ΔNp63+ basal cell hyperplasia in chronic rhinosinusitis. Journal of Allergy and Clinical Immunology (in press, corresponding, IF=14.2) 👏
Standardized Image-Based Polysomnography Database and Deep Learning Algorithm for Sleep Stage Classification. Sleep 2023 (corresponding) 🎉
Protein Stabilization of ITF2 by NF-κB Prevents Colitis-associated Cancer Development. Nature Communications 2023 (corresponding, IF=16.6) 👏
Surface Active Salivary Metabolites Indicate Oxidative Stress and Inflammation in Obstructive Sleep Apnea. Allergy Asthma Immunol Research 2023 (corresponding) 🎉
Effects of Neutrophil and Eosinophil Extracellular Trap Formation on Refractoriness in Chronic Rhinosinusitis With Nasal Polyps. Allergy Asthma Immunol Research 2023
2022
DEP-induced ZEB2 promotes nasal polyp formation via epithelial-to-mesenchymal transition. Journal of Allergy and Clinical Immunology 2022 (corresponding, IF=14.2) 👏
Loop and Bridge Conformations of ABA Triblock Comb Copolymers: A Conformational Assessment for Molecular Composites. Polymers (Basel). 2022
Optimizing Chain Topology of Bottle Brush Copolymer for Promoting the Disorder-to-Order Transition. Int J Mol Sci. 2022
2021
Does Particulate Matter Really Affect Sinusitis?. Clin Exp Otorhinolaryngol. 2021 (corresponding, IF=3.372)
Matrix stiffening enhances DNCB-induced IL-6 secretion in keratinocytes through a beta 1 integrin–FAK-dependent ERK and PI3K/Akt pathway. Frontiers in Immunology 2021 (IF=8.786)
Enhanced eosinophil-mediated inflammation associated with antibody and complement-dependent pneumonic insults in critical COVID-19. Cell Reports 2021 (IF=9.423)
Effect of Lacticaseibacillus casei AMBR2 on Epithelial Barrier Function in Chronic Rhinosinusitis With Nasal Polyps. Allergy Asthma Immunol Research 2021 (corresponding, IF=5.764)
Urine 5-Eicosatetraenoic Acids as Diagnostic Markers for Obstructive Sleep Apnea. Antioxidants 2021 (First, IF=7.675)
A nonsense TMEM43 variant leads to disruption of connexin-linked function and autosomal dominant auditory neuropathy spectrum disorder. Proc Natl Acad Sci USA 2021 (IF=11.205)
PGC1α Loss Promotes Lung Cancer Metastasis Through Epithelial-Mesenchymal Transition. Cancers 2021 (co-corresponding, IF=6.639)
SARS-CoV-2 infection of airway epithelial cells. Immune Network 2021 (corresponding, IF=6.303) *** KAI 2023 우수논문상 수상 ***
Bone morphogenetic protein-2 as a novel biomarker for refractory chronic rhinosinusitis with nasal polyps. Journal of Allergy and Clinical Immunology 2021 (co-corresponding, IF=14.290) 👏
Antibiotic-dependent relationships between the nasal microbiome and secreted proteome in nasal polyps. Allergy Asthma Immunol Research 2021 (corresponding, IF=5.764) 🎉
Effect of lipopolysaccharide and polyinosinic:polycytidylic acid in a murine model of nasal polyp. Scientific Reports 2021
2020
Epithelial-to-mesenchymal transition in neutrophilic chronic rhinosinusitis. Current Opinion in Allergy and Clinical Immunology 2020 (corresponding, IF=3.142)
Effects of Wnt signaling on epithelial to mesenchymal transition in chronic rhinosinusitis with nasal polyp. Thorax. 2020;75:982-993. (co-corresponding, IF=10.844)
Sleep Tests in the Non-Contact Era of the COVID-19 Pandemic: Home Sleep Tests Versus In-Laboratory Polysomnography. Clin Exp Otorhinolaryngol. 2020 Nov 1. (corresponding, IF=3.372)
α-Helical cell-penetrating peptide-mediated nasal delivery of resveratrol for inhibition of epithelial-to-mesenchymal transition. J Control Release. 2020 Jan 10;317:181-194. (co-corresponding, IF=9.776)
POLD1 variants leading to reduced polymerase activity can cause hearing loss without syndromic features. Hum Mutat. 2020 May;41(5):913-920.
Evaluation of neo-osteogenesis using eosinophilic chronic rhinosinusitis with nasal polyp murine model. Allergy Asthma Immunol Res. 2020 Mar; 12(2): 306–321. (corresponding, IF=5.764)
Impact of the Long-Lived Plasma Cells in Patients With Chronic Rhinosinusitis With Nasal Polyps. Allergy Asthma Immunol Res. 2020 Mar;12(2):173-175. (corresponding, IF=5.764)
Crosstalk Between Mucosal Inflammation and Bone Metabolism in Chronic Rhinosinusitis. Clin Exp Otorhinolaryngol. 2020 Sep 4 (corresponding, IF=3.372)
2019
Intermittent hypoxia promotes carcinogenesis in azoxymethane and dextran sodium sulfate-induced colon cancer model. Mol Carcinog. 2019 May;58(5):654-665. (corresponding, IF=4.784)
The IFN-γ-p38, ERK kinase axis exacerbates neutrophilic chronic rhinosinusitis by inducing the epithelial-to-mesenchymal transition. Mucosal Immunol. 2019 May;12(3):601-611. (corresponding, IF=7.313)
Nuclear FGFR2 negatively regulates hypoxia-induced cell invasion in prostate cancer by interacting with HIF-1 and HIF-2. Sci Rep. 2019 Mar 5;9(1):3480.
Human 3D cellular model of hypoxic brain injury of prematurity. Nat Med. 2019 May;25(5):784-791.
Interleukin (IL)-13 and IL-17A contribute to neo-osteogenesis in chronic rhinosinusitis by inducing RUNX2. EBioMedicine. 2019 Aug;46:330-341. (co-corresponding, IF=8.143)
In-Depth, Proteomic Analysis of Nasal Secretions from Patients With Chronic Rhinosinusitis and Nasal Polyps. Allergy Asthma Immunol Res. 2019 Sep;11(5):691-708. (corresponding, IF=5.764)
Evaluation of the feasibility and preference of Nox-A1 type 2 ambulatory device for unattended home sleep test: a randomized crossover study. Sleep Biol Rhythms. 2019;17:297-304. (corresponding)
2018
Wogonin attenuates nasal polyp formation by inducing eosinophil apoptosis through HIF-1α and survivin suppression. Scientific Reports. 2018 Apr (corresponding)
Transient Anosmia Induces Depressive-like and Anxiolytic-like Behavior and Reduces Amygdalar Corticotropin-Releasing Hormone in a ZnSO4-induced Mouse Model. Chem Senses. 2018 Apr 23;43(4):213-221.
Astrocyte-derived CCL20 reinforces HIF-1-mediated hypoxic responses in glioblastoma by stimulating the CCR6-NF-κB signaling pathway. Oncogene. 2018 Jun;37(23):3070-3087.
FIH is an oxygen sensor in ovarian cancer for G9a/GLP-driven epigenetic regulation of metastasis-related genes. Cancer Res. 2018 Mar 1;78(5):1184-1199.
Fibrinogen-cleavage products and TLR4 promote the generation of PD-L2+ DC in allergic asthma. J Allergy Clin Immunol. 2018 Aug;142(2):530-541.e6.
2017
Targeting IL-25 as a novel therapy in chronic rhinosinusitis with nasal polyps. Curr Opin Allergy Clin Immunol. 2017 Feb;17(1):17-22. (corresponding)
Accelerated tumor growth under intermittent hypoxia is associated with hypoxia-inducible factor-1-dependent adaptive responses to hypoxia. Oncotarget. 2017 Jun 27;8(37):61592-61603. (corresponding)
Urinary Metabolomic Signatures in Obstructive Sleep Apnea through Targeted Metabolic Analysis: A Pilot Study. Metabolomics. 13(8), 1-11 (2017) (co-corresponding)
Serial Analysis of Tracheal Restenosis After 3D-Printed Scaffold Implantation: Recruited Inflammatory Cells and Associated Tissue Changes. Tissue Eng Regen Med. 2017 Sep 13;14(5):631-639. (co-corresponding)
In vitro nasal mucosa gland-like structure formation on a chip. Lab Chip. 2017 May 2;17(9):1578-1584. (co-corresponding)
Immune Cell Responses and Mucosal Barrier Disruptions in Chronic Rhinosinusitis. Immune Netw. 2017 Feb;17(1):60-67. (corresponding)
Sinonasal Delivery of Resveratrol via Mucoadhesive Nanostructured Microparticles in a Nasal Polyp Mouse Model. Sci Rep. 2017 Jan 10;7:40249. (co-corresponding)
Targeting IL-25 as a novel therapy in chronic rhinosinusitis with nasal polyps. Curr Opin Allergy Clin Immunol. 2017 Feb;17(1):17-22. (corresponding)
2016
Diacetoxyscirpenol as a new anticancer agent to target hypoxia-inducible factor 1. Oncotarget. 2016 Sep 20;7(38):62107-62122.
SIRT1 attenuates nasal polypogenesis by suppressing epithelial-to-mesenchymal transition. J Allergy Clin Immunol. 2016 Jan;137(1):87-98.e7. (corresponding) *** 분쉬의학상 젊은의학자상 2017 수상 ***
Animal Models in CRS and Pathophysiologic Insights Gained: A Systematic Review. Laryngoscope Investig Otolaryngol. 2016 Aug 2;1(5):116-123. (corresponding)
Potential role of the N-MYC downstream-regulated gene family in reprogramming cancer metabolism under hypoxia. Oncotarget. 2016 Aug 30;7(35):57442-57451.
Chronic anosmia induces depressive behavior and reduced anxiety via dysregulation of glucocorticoid receptor and corticotropin-releasing hormone in a mouse model. Rhinology. 2016 Mar;54(1):80-7.
Distinct effects of SIRT1 in cancer and stromal cells on tumor promotion. Oncotarget. 2016 Apr 26;7(17):23975-87.
Induction of nasal polyps using house dust mite and Staphylococcal enterotoxin B in C57BL/6 mice. Allergol Immunopathol (Madr). Jan-Feb 2016;44(1):66-75. (corresponding)
2015
Low Quality of Life and Depressive Symptoms as an Independent Risk Factor for Erectile Dysfunction in Patients with Obstructive Sleep Apnea. J Sex Med. 2015 Nov;12(11):2168-77. (corresponding)
HIF-1α Upregulation due to Depletion of the Free Ubiquitin Pool. J Korean Med Sci. 2015 Oct;30(10):1388-95.
IL-25 as a novel therapeutic target in nasal polyps of chronic rhinosinusitis. J Allergy Clin Immunol. 2015 Jun;135(6):1476-85.e7. (first)
Antihyperglycemic mechanism of metformin occurs via the AMPK/LXRα/POMC pathway. Sci Rep. 2015 Jan 30;5:8145.
2014
Arrest defective-1 regulates the oxidative stress response in human cells and mice by acetylating methionine sulfoxide reductase A. Cell Death Dis. 2014 Oct 23;5(10):e1490.
ITF2 Prevents Activation of the βcatenin–TCF4 Complex in Colon Cancer Cells and Levels Decrease with Tumor Progression. Gastroenterology. 2014 Aug;147(2):430-442.e8. (first)
2013
Effects of Surgical vs. Nonsurgical Therapy on Erectile Dysfunction and Quality of Life in Obstructive Sleep Apnea Syndrome: A Pilot Study. J Sex Med. 2013 Aug;10(8):2053-9. (first)
Mad1 mediates hypoxia-induced doxorubicin resistance in colon cancer cells by inhibiting mitochondrial function. Free Radic Biol Med. 2013 Jul;60:201-10.
Resveratrol prevents development of eosinophilic rhinosinusitis with nasal polyps in a mouse model. Allergy. 2013 Jul;68(7):862-9.
Pathogenic role of HIF-1a in prostate hyperplasia in the presence of chronic inflammation. Biochim Biophys Acta. 2013 Jan;1832(1):183-94.