Peer reviewer & preLights

2019–Ongoing         Journal peer reviewer

-        eLife, eLife Sciences Publications Ltd., UK

-        Nature Communications, Nature Publishing group

-        Journal of Cachexia, Sarcopenia and Muscle, John Wiley & Sons

-        FASEB Journal, Federation of American Societies for Experimental Biology, John Wiley & Sons

-        Open Biology, The Royal Society Publishing

-        Journal of Biological Chemistry (JBC), American Society for Biochemistry and Molecular Biology

-        Protein & Cell, Springer, and Higher Education Press

-        Life Science Alliance, EMBO Press

-        Developmental Biology, Society for Developmental Biology, Elsevier, Netherlands

-        iScience, CellPress, Elsevier

-        Journal of Molecular and Cellular Cardiology (JMCC)

-        Current Opinion in Pharmacology, Elsevier

-        British Journal of Pharmacology, British Pharmacological Society

-        Journal of Cell Communication and Signaling, Springer Nature, Switzerland

-        Cellular Signalling, Elsevier

-        Frontiers in Cell and Developmental Biology, Swiss Federal Institute of Technology in Lausanne (EPFL), Switzerland

-        Frontiers in Physiology, Swiss Federal Institute of Technology in Lausanne (EPFL), Switzerland

-        STAR Protocols, CellPress, Elsevier

-        Scientific Reports, Nature Portfolio

-        Journal of Visualized Experiments (JoVE)

-        Frontiers in Cardiovascular Medicine, Swiss Federal Institute of Technology in Lausanne (EPFL), Switzerland

-        Clinical Science, Portland Press, Biochemical Society, London, UK

-        Experimental Gerontology, Elsevier, Netherlands

-        Cells, Member of the Reviewer Board, MDPI, Basel, Switzerland

-        Ageing Research Reviews, Elsevier

-        International Journal of Molecular Sciences, MDPI, Basel, Switzerland

-        Genes, MDPI, Basel, Switzerland

-        Biomedicines, MDPI, Basel, Switzerland

-        Biochimie, Société Française de Biochimie et Biologie Moléculaire, Elsevier

-        Biology, MDPI, Basel, Switzerland

-        Biomolecules, MDPI, Basel, Switzerland

June 2022      Peer reviewer – contributor to Reactome (Version 81 Released on 14 June 2022; Signal Transduction (Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer)

Being a PreLighter

I’m part of the carefully selected group of early-career researchers called PreLights community from The Company of Biologists, UK. Visit my profile: https://prelights.biologists.com/profiles/osvaldo-contreras/.

My Highlights:

1. https://prelights.biologists.com/highlights/a-transcriptional-switch-governing-fibroblast-plasticity-underlies-reversibility-of-chronic-heart-disease/

Here, we discussed why mammalian cardiac regeneration and repair do not occur in adults and account for new potential ways of improving heart failure and fibrosis. By Osvaldo Contreras & Alex Ward.

2. https://prelights.biologists.com/highlights/human-skeletal-muscle-cd90-fibro-adipogenic-progenitors-are-associated-with-muscle-degeneration-in-type-2-diabetic-patients/

Here, we highlighted the unknown role of skeletal muscle FAP cells in degenerative settings, including disease, obesity and type 2 diabetes. By Osvaldo Contreras & Nicolás Collao.

3. https://prelights.biologists.com/highlights/bromodomain-inhibition-blocks-inflammation-induced-cardiac-dysfunction-and-sars-cov2-infection-in-pre-clinical-models/

Here, we summarized the last finding of the damaging effects of SARS-CoV2 in the heart and explain the last wonderful article published in BiorXiv from James Hudson Lab at the QIMR Berghofer Medical Research Institute. By Alex Ward & Osvaldo Contreras

4. Coronary blood vessels from distinct origins converge to equivalent states during mouse and human development

In this Prelight, we summarized why and how D'Amato and Krysty Red-Horse Labs used scRNA-seq combined with endothelial cell lineage-tracing to explore for the first time the dual origins of coronary blood vessels during mouse and human development. By Yen Tran & Osvaldo Contreras

5. Multiscale light-sheet organoid imaging framework

In this exciting new preprint, Liberali and colleagues leverage their extensive organoid-imaging knowledge [3] to present LSTree (an acronym for Light-Sheet Tree), a light-sheet imaging framework to analyze and digitally visualize organoids. LST goes from image pre-processing, cell lineage tracking, and segmentation to analytical tools to extract morphological and microscopy features. The authors used this light-sheet microscopy-based imaging framework to analyze and reconstruct, at an unprecedented spatiotemporal resolution, the cell growing dynamics and cell lineage relationships during intestinal organoid development.