Differentiation is a journal published on behalf of the International Society of Differentiation. It publishes articles on cell & tissue differentiation, organogenesis, development, cellular structure and function.
Submissions on differentiation at the molecular, cellular and tissue levels, and the use of transgenic, targeted mutagenesis, transcriptomic, computational and synthetic approaches to problems of differentiation are particularly welcomed.
Differentiation publishes full-length articles and research reports containing original work in any of these areas. We also welcome reviews and commentaries on topics of current interest, as well as perspectives.
The journal publishes topics including:
• Embryonic patterning and organogenesis in diverse research organisms
• Human development and congenital malformation
• Mechanisms of cell lineage commitment
• Stem cell differentiation
• Cell reprogramming mechanisms
• Stability of the differentiated state
• Cell and tissue interactions in vivo and in vitro
• Signal transduction pathways in development and differentiation
• Differentiation in regeneration and ageing
• Therapeutic and synthetic applications of differentiation processes
Osvaldo will use the Micro Imaging Facility and Biomedical Data Science Facility to study the human cell cycle and chromatin remodelling in response to DNA replication stress.
Honoured to be part of the very few Oceania eLife Ambassadors @eLifeCommunity. It allowed me to learn tons about publishing, and culture initiatives, and to start reviewing manuscripts for @eLife
Osvaldo quotes:
“Reviewing manuscripts for eLife has been a unique way to pay forward and enrich the open-publishing model that eLife is pushing forward. I look forward to submitting my very own work shortly.”
Very honoured to participate in TrendsTalk (Trends in Biochemical Sciences) as Co-Chair of the new global IUBMB Trainee Initiative together with my fantastic colleagues Élyse Fischer, PhD (Chair), Brianna (Bri) Bibel (PhD), and Victoria Patten (PhD(c)).
https://www.sciencedirect.com/science/article/pii/S0968000422000871
TrendsTalk is a series of discussions and interviews with relevant scientists discussing new topics, discoveries, and motivations to pursue their careers in science and academia. I am totally in debt to Prof. Alexandra Newton (President IUBMB) and Sannie Culbertson, PhD, Trends in Biochemical Sciences, for their invitation to participate in TrendsTalk.
Osvaldo wrotes:
"I have always been driven by an uncontrollable curiosity and by my eagerness to learn new things and share knowledge and experiences. Coming from a rural town to become a first-generation biologist, I later realized the many faces of research and academia and how kindness and leadership can make a massive difference in trainees' lives and experiences. What initially motivated me was the broad representation that IUBMB has around the globe and the fact of coming to work with early-career researchers (ECRs) worldwide to be part of the change I want to see."
I am delighted to announce I will be joining #eLifeAmbassadors Programme for 2022-2033 together with 128 other amazing ECRs, facilitating advocates of responsible science practices to learn from each other and create change across the global research community.
“Early-career researchers are literally the future of science. Connecting like-minded individuals at this stage in their careers, and fostering the sense of an international interdependent community among them offers the hope that the future of research will be all about openness and collaboration.” – Damian Pattinson, eLife’s Executive Director
Osvaldo also joins the Chilean Biological Society as an invited new Member.
I’m incredibly excited to announce that a group of proud biochemistry geeks, including myself, are starting the IUBMB (International Union of Biochemistry and Molecular Biology) Trainee Initiative. And you can join us!
Our current trainee representatives include our chair, Elyse Fischer, our co-chair Osvaldo Contreras, Nefeli Boni-Katzantzidou, Chloe Lieng, Sunnie Kong, Hannah Pletcher, Elodie Ekoka, Victoria Patten, Tatenda Murigo, and Brianna Bibel.
https://thebumblingbiochemist.com/365-days-of-science/introducing-iubmb-trainee-initiative/
You can now follow us on Instagram & Twitter (@iubmb_trainee)!
You can also email us at [trainee.initiative@gmail.com] with you ideas, suggestions, and questions.
24th January 2022
Osvaldo Contreras is a Chilean molecular and cell biologist working as a postdoctoral researcher in the lab of Prof. Richard Harvey at the Victor Chang Cardiac Research Institute (VCCRI) in Sydney, Australia, where he investigates heart development and repair. He completed his PhD in Prof. Enrique Brandan’s lab at the Pontifical Catholic University of Chile, in conjunction with Prof. Fabio Rossi at the University of British Columbia. He has contributed a number of posts since joining the preLights community in 2020 and is also an active member of the Sydney Postdoctoral Development Committee (PDDC). We spoke to Osvaldo about his research, making big international moves for science, and being part of preLights and the PDDC.
https://prelights.biologists.com/news/meet-the-prelighters-osvaldo-contreras/
“To be, or not to be a myofibroblast, that is the question”.
Dr. Alex Ward and I Highlighted the last work of Haldar and Srivastava published in BioRxiv. Access to our first Prelight in the following link: https://prelights.biologists.com/highlights/a-transcriptional-switch-governing-fibroblast-plasticity-underlies-reversibility-of-chronic-heart-disease/
Here we discussed why mammalian cardiac regeneration and repair do not occur in adults and account for new potential ways of improving heart failure. Read more about the PreLights community of The Company of Biologists.
A novel interplay between the Wnt and TGF-β pathways that regulates MSC fate and fibrosis:
Fibroblastos: células causantes de fibrosis. Pontificia Universidad Católica de Chile, Facultad de Ciencias Biológicas
In this study, Osvaldo Contreras, Enrique Brandan and colleagues (Contreras et al., 2020) demonstrate that transforming growth factor beta (TGF-β) regulates the expression of the T-cell factor or lymphoid enhancer factor (TCF/LEF) transcription factor TCF7L2 (also known as TCF4) in MSCs and fibroblasts.
"Role of the Wnt Transcription Factor TCF7L2 in Mesenchymal Progenitor Cells"