Highlighted Articles

Research Articles

Acute stress induces circuit-specific alterations in mesolimbic and nigrostriatal inhibitory transmission and potentiates operant learning

Schuch HC, Woo J, Kugler H, Jiang K, & Ostroumov A.

Neuropharmacology. 2026

Dynamic changes in chloride homeostasis coordinate midbrain inhibitory network activity during reward learning

Woo J, Uprety A, Reid DJ, Chang I, Samuel AK, Schuch HC, Swain CC, & Ostroumov A.

Nature Comms. 2025

Cocaine and Morphine Converge to Disrupt Chloride Homeostasis in Ventral Tegmental Area GABA Neurons

Pearson AC, Kimmey BA, Taormina MB, Holden WM, & Ostroumov A.

Addict Biol. 2025

Midbrain KCC2 downregulation: Implications for stress-related and substance use behaviors.

Pearson AC & Ostroumov A.

Current Opinion in Neurobiology. 2024

The serotonin 2A receptor agonist TCB-2 attenuates heavy alcohol drinking and alcohol-induced midbrain inhibitory plasticity

Kimmey BA, Wittenberg RE, Croicu A, Shadani N, Ostroumov A, Dani JA.

Addict Biol. 2022

Ethanol produces multiple electrophysiological effects on ventral tegmental area neurons in freely moving rats.

Doyon WM, Ostroumov A, Ontiveros T, Gonzales RA, Dani JA.

Addict Biol. 2020

Acute Nicotine Exposure Alters Ventral Tegmental Area Inhibitory Transmission and Promotes Diazepam Consumption.

Ostroumov A, Wittenberg RE, Kimmey BA, Taormina MB, Holden WM, McHugh AT, Dani JA.

eNeuro. 2020

5-HT2A receptor activation normalizes stress-induced dysregulation of GABAergic signaling in the ventral tegmental area.

Kimmey BA, Ostroumov A, Dani JA.

Proc Natl Acad Sci U S A. 2019

Adolescent Nicotine Exposure Alters GABAA Receptor Signaling in the Ventral Tegmental Area and Increases Adult Ethanol Self-Administration.

Thomas AM*, Ostroumov A*, Kimmey BA, Taormina MB, Holden WM, Kim K, Brown-Mangum T, Dani JA.

Cell Rep. 2018  *Co-first authors

Stress Increases Ethanol Self-Administration via a Shift toward Excitatory GABA Signaling in the Ventral Tegmental Area.

Ostroumov A*, Thomas AM*, Kimmey BA, Karsch JS, Doyon WM, Dani JA.

Neuron. 2016  *Co-first authors

Nicotine decreases ethanol-induced dopamine signaling and increases self-administration via stress hormones.

Doyon WM, Dong Y, Ostroumov A, Thomas AM, Zhang TA, Dani JA.

Neuron. 2013

The mechanisms of inhibition of frog endplate currents with homologous derivatives of the 1,1-dimethyl-3-oxybutyl phosphonic acid.

Pryazhnikov E, Ostroumov A, Druginina O, Vyskočil F, Skorinkin A.

Physiol Res. 2012

Cystic fibrosis transmembrane conductance regulator modulates synaptic chloride homeostasis in motoneurons of the rat spinal cord during neonatal development.

Ostroumov A, Simonetti M, Nistri A.

Dev Neurobiol. 2011

Review Articles

Inhibitory Plasticity of Mesocorticolimbic Circuits in Addiction and Mental Illness.

Ostroumov A, Dani JA.

Trends Neurosci. 2018

Convergent Neuronal Plasticity and Metaplasticity Mechanisms of Stress, Nicotine, and Alcohol.

Ostroumov A, Dani JA.

Annu Rev Pharmacol Toxicol. 2018

Cigarettes and alcohol: The influence of nicotine on operant alcohol self-administration and the mesolimbic dopamine system.

Ostroumov A, Thomas AM, Dani JA, Doyon WM.

Biochem Pharmacol. 2015

Potential substrates for nicotine and alcohol interactions: a focus on the mesocorticolimbic dopamine system.

Doyon WM, Thomas AM, Ostroumov A, Dong Y, Dani JA.

Biochem Pharmacol. 2013