Embedded Files
This model was created in the NetLogo framework based on the paper https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1009239. New parameter values were identified in order to reproduce the experimental resting membrane potential of a piriform cortex neuron (-55mv aprox) at postnatal day 14.
In this link you will have access to the data
(results of simulations 4 groups and control group) : https://drive.google.com/file/d/1UCPDFrJeiK_u30rW4F3dgfCAFo7Mbc9u/view?usp=drive_link
You will be able to run the code online using NetLogo Web
The following figure shows the simulation at tick # 813: (8.12ms)
The following figure shows the simulation at tick #1547 , (15.46ms)
You can see that with 100% activity of KCC and NKCC, the membrane potential remains stable at –55 mV. aprox
“To run the model online, follow the instructions:
Download NKCC-KCC2Stablemodelo.nlogo from link xxxxxxx
On the next page, upload the file NKCC-KCC2Stablemodelo.nlogo using ‘Upload a Model: Browse’.
Click Create and then Go.”
It is also possible to run the model on your computer. To do so, you need to install NetLogo from NetLogo Home or Download any NetLogo version 6.4.0
The following figure shows the simulation at 2762.8ms. You can see that with 100% activity of KCC and NKCC, the membrane potential remains stable at –55 mV. aprox.
This figure shows the neural activity in response to a GABAergic synaptic input. (This visualization is generated when the model is run on a PC.)
“Dear Reviewers,
The reversal potential of ions varies over time in response to GABAergic synaptic input. In the manuscript, we demonstrate that varying the concentrations of NKCC and KCC leads to differences in both the number of spikes and the firing rate.”
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