H. Etori, R. Asoshina, T. Obita, F. Okumura. Spermidine reduces ISGylation and enhances ISG15–USP18 interaction, Scientific Reports, 15:17913 (2025) IF=4.3

K. Nonaka, K. Nishimura, K. Uesaka, E. Mishiro-Sato, M. Fukase, R. Kato, F. Okumura, K. Nakatsukasa, K. Obara, T. Kamura. Snf1 and yeast GSK3-beta activates Tda1 to suppress glucose starvation signaling, EMBO Reports, (2025) IF=6.5

Ikeda, T., Yamazaki, K., Okumura, F., Kamura, T.*, and Nakatsukasa, K.* Role of the San1 ubiquitin ligase in the heat stress-induced degradation of non-native Nup1 in the nuclear pore complex, Genetics, iyae017 (2024) IF=4.402

Nishio, K., Kawarasaki, T., Sugiura, Y., Matsumoto, S., Konoshima, A., Takano, Y., Hayashi, M., Okumura, F., Kamura, T.*, Mizushima, T.*, and Nakatsukasa, K.* Defective import of mitochondrial metabolic enzyme elicits ectopic metabolic stress, Science Advances, 9, eadf1956 (2023) IF=15.388

Nakatsukasa, K.*, Fujisawa, M., Yang, X., Kawarasaki, T., Okumura, F., and Kamura, T.* Triacylglycerol lipase Tgl4 is a stable protein and its dephosphorylation is regulated in a cell cycle-dependent manner in Saccharomyces cerevisiae, Biochemical and Biophysical Research Communications, 626, 85-91  (2022) IF=3.344

Oki, N., Yamada, S., Tanaka, T., Fukui, H., Hatakeyama, S., and Okumura, F.* Curcumin partly prevents ISG15 activation via ubiquitin-activating enzyme E1-like protein and decreases ISGylation, Biochemical and Biophysical Research Communications, 625, 94-101 (2022) IF=3.344

Kusama, K., Suzuki, Y., Kurita, E., Kawarasaki, T., Obara, K., Okumura, F., Kamura, T., and Nakatsukasa, K.* Dot6/Tod6 degradation fine-tunes the repression of ribosome biogenesis under nutrient-limited conditions, iScience 25, 103986 (2022). IF=6.107

Okumura, F.*, Oki, N., Fujiki, Y., Ikuta R., Osaki, K., Hamada S., Nakatsukasa, K., Hisamoto N., Hara T., and Kamura, T.* ZSWIM8 is a myogenic protein that partly prevents C2C12 differentiation, Scientific Reports 11:20880 (2021) Co-corresponding author IF=5.516

Okumura, F.*, Fujiki, Y., Oki, N., Osaki, K., Nishikimi, A., Fukui, Y., Nakatsukasa, K., & Kamura, T.*, Cul5-type ubiquitin ligase KLHDC1 contributes to the elimination of truncated SELENOS produced by failed UGA/Sec decoding, iScience 100970, Co-corresponding author (2020) IF=5.74

Tognon, C. E., Rafn, B., Cetinbas, N. M., Kamura, T., Trigo, G., Rotblat, B., Okumura, F. , Matsumoto, M., Chow, C., Davare, M., Pollak, M., Mayor, T., and Sorensen, P. H.* Insulin-like growth factor 1 receptor stabilizes the ETV6-NTRK3 chimeric oncoprotein by blocking its KPC1/Rnf123-mediated proteasomal degradation, Journal of Biological Chemistry 293, 12502-12515. (2018) IF=4.093

Nakatsukasa, K.*, Sone, M., Alemayehu, D. H., Okumura, F. , & Kamura, T.* The HECT-type ubiquitin ligase Tom1 contributes to the turnover of Spo12, a component of the FEAR network, in G2/M phase, FEBS letters 592, 1716-1724. 1. (2018) IF=2.953

Okumura, F. *, Joo-Okumura, A., Obara, K., Petersen, A., Nishikimi, A., Fukui, Y., Nakatsukasa, K. & Kamura, T.* Ubiquitin ligase SPSB4 diminishes cell repulsive responses mediated by EphB2. Molecular Biology of the Cell. 15;28(24):3532-3541. (2017) Co-corresponding author IF=3.77

Okumura, F.*, Joo-Okumura, A., Nakatsukasa, K. & Kamura, T.* Hypoxia-inducible factor-2a stabilizes the von Hippel-Lindau (VHL) disease suppressor, Myb-related protein 2. PLoS One. 10;12(4) (2017) Co-corresponding author IF=3.196

Uematsu, K., Okumura, F.*, Tonogai, S., Joo-Okumura, A., Alemayehu, D. H., Nishikimi, A., Fukui, Y., Nakatsukasa, K. & Kamura, T.* ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation, Journal of Cell Biology. 215, 95-106. (2016) Co-first and co-corresponding author IF=7.146

Okumura, F.*, Uematsu, K., Byrne, S. D., Hirano, M., Joo-Okumura, A., Nishikimi, A., Shuin, T., Fukui, Y., Nakatsukasa, K. & Kamura, T.* Parallel Regulation of von Hippel-Lindau Disease by pVHL-Mediated Degradation of B-Myb and Hypoxia-Inducible Factor alpha, Molecular and Cellular Biology. 36, 1803-17. (2016) Co-corresponding author IF=4.574

Nakatsukasa, K.*, Nishimura, T., Byrne, S. D., Okamoto, M., Takahashi-Nakaguchi, A., Chibana, H., Okumura, F. & Kamura, T.* The Ubiquitin Ligase SCF(Ucc1) Acts as a Metabolic Switch for the Glyoxylate Cycle, Molecular Cell. 59, 22-34. (2015) IF=12.977

Yaguchi, H., Yabe, I., Takahashi, H., Okumura, F., Takeuchi, A., Horiuchi, K., Kano, T., Kanda, A., Saito, W., Matsumoto, M., Nakayama, K. I., Hatakeyama, S. & Sasaki, H.* Identification of anti-Sez6l2 antibody in a patient with cerebellar ataxia and retinopathy, Journal of Neurology. 261, 224-6. (2014) IF=2.837

Nakatsukasa, K.*, Kanada, A., Matsuzaki, M., Byrne, S. D., Okumura, F. & Kamura, T.* The Nutrient Stress-induced Small GTPase Rab5 Contributes to the Activation of Vesicle Trafficking and Vacuolar Activity, Journal of Biological Chemistry. 289, 20970-20978. (2014) IF=4.967

Okumura, F.*, Okumura, A. J., Uematsu, K., Hatakeyama, S., Zhang, D. E. & Kamura, T.* Activation of Double-stranded RNA-activated Protein Kinase (PKR) by Interferon-stimulated Gene 15 (ISG15) Modification Down-regulates Protein Translation, Journal of Biological Chemistry. 288, 2839-47. (2013) Co-corresponding author IF=5.114

Yaguchi, H., Okumura, F., Takahashi, H., Kano, T., Kameda, H., Uchigashima, M., Tanaka, S., Watanabe, M., Sasaki, H. & Hatakeyama, S.* TRIM67 protein negatively regulates Ras activity through degradation of 80K-H and induces neuritogenesis, Journal of Biological Chemistry. 287, 12050-12059. (2012) IF=5.245

Sato, T., Okumura, F., Iguchi, A., Ariga, T. & Hatakeyama, S.* TRIM32 promotes retinoic acid receptor alpha-mediated differentiation in human promyelogenous, leukemic cell line HL60, Biochemical and Biophysical Research Communications. 417, 594-600. (2012) IF=2.833

Sato, T., Okumura, F., Ariga, T. & Hatakeyama, S.* TRIM6 interacts with Myc and maintains pluripotency of mouse embryonic stem cells, Journal of Cell Science. 125(Pt 6), 1544-1555. (2012) IF=6.404

Sato, T., Okumura, F., Kano, S., Kondo, T., Ariga, T. & Hatakeyama, S.* TRIM32 promotes neural differentiation through retinoic acid receptor-mediated transcription, Journal of Cell Science. 124, 3492-502. (2011) IF=6.307

Okumura, F., Yoshida, K., Liang, F. & Hatakeyama, S.* MDA-9/syntenin interacts with ubiquitin via a novel ubiquitin-binding motif, Molecular and Cellular Biochemistry. 352, 163-72. (2011) IF=2.311

Okumura, F., Okumura, A. J., Matsumoto, M., Nakayama, K. I. & Hatakeyama, S.* TRIM8 regulates Nanog via Hsp90b-mediated nuclear translocation of STAT3 in embryonic stem cells, Biochimica et Biophysica Acta. 1813, 1784-92. (2011) IF=5.745

Noguchi, K., Okumura, F., Takahashi, N., Kataoka, A., Kamiyama, T., Todo, S. & Hatakeyama, S.* TRIM40 promotes neddylation of IKK{gamma} and is downregulated in gastrointestinal cancers, Carcinogenesis. 32, 995-1004. (2011) IF=6.306

Bohgaki, M., Matsumoto, M., Atsumi, T., Kondo, T., Yasuda, S., Horita, T., Nakayama, K. I., Okumura, F., Hatakeyama, S.* & Koike, T. Plasma gelsolin facilitates interaction between beta(2) glycoprotein I and alpha(5) beta(1) integrin, Journal of Cellular and Molecular Medicine. 15, 141-51. (2011) IF=4.426

Shinada, K., Tsukiyama, T., Sho, T., Okumura, F., Asaka, M. & Hatakeyama, S.* RNF43 interacts with NEDL1 and regulates p53-mediated transcription, Biochemical and Biophysical Research Communications. 404, 143-7. (2011) IF=2.825

Okumura, F., Matsunaga, Y., Katayama, Y., Nakayama, K. I. & Hatakeyama, S.* TRIM8 modulates STAT3 activity through negative regulation of PIAS3, Journal of Cell Science. 123, 2238-45. (2010) IF=6.366

Okumura, F., Kameda, H., Ojima, T. & Hatakeyama, S.* Expression of recombinant sea urchin cellulase SnEG54 using mammalian cell lines, Biochemical and Biophysical Research Communications. 395, 352-5. (2010) IF=2.854

Suizu, F., Hiramuki, Y., Okumura, F., Matsuda, M., Okumura, A. J., Hirata, N., Narita, M., Kohno, T., Yokota, J., Bohgaki, M., Obuse, C., Hatakeyama, S., Obata, T. & Noguchi, M.* The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt, Developmental Cell. 17, 800-10. (2009) IF=9.793

Maeda, H., Miyajima, N., Kano, S., Tsukiyama, T., Okumura, F., Fukuda, S. & Hatakeyama, S.* Ubiquitin-conjugating enzyme UBE2Q2 suppresses cell proliferation and is down-regulated in recurrent head and neck cancer, Molecular Cancer Research. 7, 1553-62. (2009) IF=4.648

Kikuchi, M., Okumura, F., Tsukiyama, T., Watanabe, M., Miyajima, N., Tanaka, J., Imamura, M. & Hatakeyama, S.* TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells, Biochimica et Biophysica Acta. 1793, 1828-36. (2009) IF=5.017

Okumura, F., Lenschow, D. J. & Zhang, D. E.* Nitrosylation of ISG15 prevents the disulfide bond-mediated dimerization of ISG15 and contributes to effective ISGylation, Journal of Biological Chemistry. 283, 24484-8. (2008) IF=5.804

Okumura, A. J., Peterson, L. F., Okumura, F., Boyapati, A. & Zhang, D. E.* t(8;21)(q22;q22) Fusion proteins preferentially bind to duplicated AML1/RUNX1 DNA-binding sequences to differentially regulate gene expression, Blood. 112, 1392-401. (2008) IF=7.997

Okumura, F., Zou, W. & Zhang, D. E.* ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP, Genes & Development. 21, 255-60. (2007) IF=15.161

Okumura, A. J., Hatsuzawa, K., Tamura, T., Nagaya, H., Saeki, K., Okumura, F., Nagao, K., Nishikawa, M., Yoshimura, A. & Wada, I.* Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system, Journal of Biological Chemistry. 281, 4495-506. (2006) IF=6.314

Yada, M., Hatakeyama, S., Kamura, T., Nishiyama, M., Tsunematsu, R., Imaki, H., Ishida, N., Okumura, F., Nakayama, K. & Nakayama, K. I.* Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7, EMBO J. 23, 2116-25. (2004) IF=10.842

Okumura, F., Hatakeyama, S., Matsumoto, M., Kamura, T. & Nakayama, K. I.* Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis, Journal of Biological Chemistry. 279, 53533-43. (2004) IF=6.57

Kamura, T., Hara, T., Matsumoto, M., Ishida, N., Okumura, F., Hatakeyama, S., Yoshida, M., Nakayama, K. & Nakayama, K. I.* Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase, Nature Cell Biology. 6, 1229-35. (2004) IF=13.471

奥村 文彦、KLHDC1 によるSELENOS の品質管理が小胞体ストレスを蓄積させる、アレルギーリウマチ性疾患45(10)、616、34-38、2025年9月号

奥村 文彦、ユビキチンリガーゼKLHDC1による小胞体膜タンパク質SELENOSの品質管理、 BIO Clinica 39(14)、84-88、2024年12月号

奥村 文彦、KLHDC1による不良SELENOSの除去、 月刊「細胞」2024年11月号

奥村 文彦、嘉村 巧、ユビキチンリガーゼKLHDC1によるセレノプロテインSの品質管理、月刊「細胞」2022年11月号

奥村 文彦、嘉村 巧、KLHDC1による不良SELENOSの除去、月刊「細胞」2021年 3月号24－27

奥村文彦、嘉村巧、1回膜貫通タンパク質EphB2のユビキチン-プロテアソーム系による分解 、生化学 第91巻第5 号681-685（2019）

奥村 文彦、ISG15 修飾、生体の科学 69（ 5 ）：462─463，2018

Okumura, F.*, Joo-Okumura, A., Nakatsukasa, K. & Kamura, T.* The role of cullin 5-containing ubiquitin ligases, Cell Division. 11, 1. (2016) Co-corresponding author

Nakatsukasa, K.*, Okumura, F. & Kamura, T.* Proteolytic regulation of metabolic enzymes by E3 ubiquitin ligase complexes: lessons from yeast, Critical Reviews in Biochemistry and Molecular Biology, 50 (6): 489–502. (2015) 

Okumura, F.*, Okumura, A., Nakatsukasa, K. & Kamura, T.* Elongin BC 型 E3ユビキチンリガーゼと細胞機能制御、生化学. 85, 76-88. (2013) Co-corresponding author

Okumura, F.*, Matsuzaki, M., Nakatsukasa, K. & Kamura, T.* The Role of Elongin BC-Containing Ubiquitin Ligases, Frontiers in Oncology. 2, 10. (2012)  Co-corresponding author

Okumura, F.* ユビキチン様分子ISG15による免疫反応制御 生化学. 81, 223-32. (2009) Corresponding author