Kessler et al. 2020 PNAS de novo mutation calls. “parse_DNM_location.data_release.out" has all the de novo mutations called by our filtering approach from the Freeze 4 TOPMed data (hg19). This includes INDELs and any recurrent mutations (both across siblings and non-siblings). The other two files contain the single nucleotide call sets used for many of the analysis in the paper. One file has coordinates for hg19 and the other for hg38. The latter files include tri-nucleotide context, and none of the files have proband IDs given the identification constraints.