Conference Abstracts

Oral Presentation

1.  Yeh CY, Chang YC*, SLC25A11 reprograms energy metabolism and mitochondrial events to promote CCA tumorigenesis and inhibit ferroptosis. 2024 The 38th Joint Annual Conference of Biomedical Science, Taipei, Taiwan (Honorable Mention Award)

2.  Lin BS, Cai HY, Chang YC. Overexpression of PFAS in urothelial carcinoma leads to proliferation and progression. 2023 Year Annual Academic Poster Seminar, Taipei, Taiwan. (Outstanding Award)

3.  Lin BS, Cai HY, Chang YC. Overexpression of the de novo purine biosynthesis enzyme PFAS confers urothelial carcinoma proliferation and tumorigenicity via Myc positive feedback loop. 2023 Merck Young Scientist Award, Tainan, Taiwan. (New Star Award)

4.  Lin BS, Cai HY, Chang YC. Overexpression of the de novo purine biosynthesis enzyme PFAS confers urothelial carcinoma proliferation and tumorigenicity via Myc positive feedback loop. 2023 The 37th Joint Annual Conference of Biomedical Science, Taipei, Taiwan (獲選大會演講)

5.  Chang YC, Hsiao M. Loss-of-Function Aldolase C Hypermethylation Cause Serotonin Production in Glioblastoma. 2020 Annual Meeting at Experimental Biology. San Diego, CA, USA. (Virtual)

6.  Chang YC, Hsiao M. Interactions of Aldolase A with ATPase Inhibitory Factor 1 Reprogram Energy Metabolism to Maintain Cancer Stemness. 2019 Annual Meeting at Experimental Biology. Orlando, FL, USA.

7.  Chang YC, Hsiao M. Non-enzymatic Functions of Aldolase A Induce Oct4 Activation to Promote Lung Cancer Stemness. 2018 Annual Meeting at Experimental Biology. San Diego, USA, Apr. 21. to Apr. 25, 2018.

8.  Chang YC, Hsiao M. Solute Carrier Family 2 Member 4 Regulates TRIM24-DDX58 Axis to Promote Head and Neck Cancer Metastasis. 2017 American society for Investigative Pathology (ASIP) Annual Meeting, Chicago, IL, USA. (Selected for Outstanding Graduate Study Performance)

9.  Chang YC, Jan YH, Su CY, Hsiao M. Non-glycolytic Function of Aldolase A Promotes Lung Cancer Metastasis through Down-regulation of PLD2 Enzyme to Activate PLD1. 2015 American society for Investigative Pathology (ASIP) Annual Meeting, Mar. 28 to Apr. 1, Boston, MA, USA

10.  Chang YC, Jan YH, Su CY, Hsiao M. Aldolase A Interplays PLD1/2 Activity through Its Enzyme-independent Function to Promote Lung Cancer Metastasis. 2015 The 30th Joint Annual Conference of Biomedical Science, Taipei, Taiwan

11.  Chang YC, Hsiao M. Identification of ALDOA as a new Lung adenocarcinoma predict gene involve cancer. metabolism and tumor metastasis. 2013 American society for Investigative Pathology Annual Meeting, Apr. 20 to 24. Boston, MA, USA

Poster Presentation

12.  You-Yu Lin, Yu-Tang Huang, Chih-Jen Yang, Chi-Ying F. Huang and Yu-Chan Chang. IL-8 overcomes osimertinib resistance by inhibiting lung adenocarcinoma cell proliferation, tumoroid formation and tumorigenesis. 2025 Merck Young Scientist Award. Cancer Immunology Section, Merit Award.

13.  Lin YY, Chang YC*. Compromise IL-8 overcomes Osimertinib resistance by inhibiting NSCLC cells, tumoroids formation and suppressing tumorigenesis. 2025 The 39th Joint Annual Conference of Biomedical Science, Taipei, Taiwan (3rd prize for the best paper award)

14.  Han His Kuo, You-Yu Lin, Zhao-Jing He, Yu-Chan Chang*. ALDOA reprograms stemness and mitochondrial function in lung cancer by facilitating lactylation of m6A regulators. 2025 American Association of Cancer Research. Chicago, IL, USA.

15.  Han His Kuo, Yu-Chan Chang*. Radiation supports the chemotaxis of M1 macrophages against triple-negative breast cancer cells via the IKZF1 - CCL5 axis. 2025 American Association of Cancer Research. Chicago, IL, USA.

16.  Yi-Fang Yang, Ming-Hsien Chan, Chi-Long Chen, Michael Hsiao, Yu-Chan Chang*. ALDOC as an indicator of HMGB1 blockade combined with checkpoint inhibitor-based immunotherapy in GBM patients. 2024 American Association of Cancer Research. San Diego, CA, USA.

17.  Yu-Chan Chang, Chi-Long Chen. ALDOB regulates fructose metabolism to confer ferroptosis and immune response in colorectal cancer harboring microsatellite instability. 2024 American Association of Cancer Research. San Diego, CA, USA.

18.  Kuo HH, Tan CX, Tsai YC, Yeh CY, Chang YC*, Chuang HY. Radiation-modulated M1 macrophage polarization and enhanced phagocytosis against triple-negative breast cancer cells. 2024 The 38th Joint Annual Conference of Biomedical Science, Taipei, Taiwan (1st prize for the best paper award)

19.  Cai HY, Lin BS, Chang YC. Estrogen receptor α inhibition enhances radiosensitization of breast cancer cells. 2023 The 37th Joint Annual Conference of Biomedical Science, Taipei, Taiwan

20.  Chien-Hsiu Li, Ming-Hsien Chan, Yu-Chan Chang. ALDOC interplays with KIAA1409 to reduce m6A modifications and cancer-associated fibroblast characteristics in gliomas. 2023 American Association of Cancer Research. Orlando, FL, USA.

21.  Yu-Chan Chang, Michael Hsiao. The effect of Aldolase C reflects the neurotransmitter secretion and PPARγ signaling in Glioblastoma. 2022 Annual Meeting at Experimental Biology. Philadelphia, PA, USA.

22.  Bo-Syuan Lin, Yu-Chan Chang. Purine biosynthesis and related enzymes play the oncogenic function in FGFR3 mutant urothelial carcinoma. 2022 Annual Meeting at Experimental Biology. Philadelphia, PA, USA.

23.  Bo-Syuan Lin, Zhi-Xuan Chang, Yu-Chan Chang. V-ATPase Family Reflects Radiosensitivity and Neutralizes Tumor-Infiltrating Lymphocytes of Glioblastoma Cells. 2022 The 36th Joint Annual Conference of Biomedical Science, Taipei, Taiwan

24.  Huei-Yu Cai, Zhi-Xuan Chang, Yu-Chan Chang. Aldolase A induces Phospholipase D reprogram to resist alkylating agents and radiation in lung cancer cells. 2022 The 36th Joint Annual Conference of Biomedical Science, Taipei, Taiwan

25.  Chang YC, Chan MS, Hsiao M. Tumor Metastasis Specific Peptide- NIR Persistent Luminescence Nanoparticles Conjugated Application: Next-Generation Theranostic Approach. 2020 Federation of Asian Societies for Molecular Imaging (FASMI). Taipei, Taiwan.

26.  Chang YC, Chen MH, Hsiao M. Regorafenib targets YAP1 to inhibit epithelial-mesenchymal transition and cancer metastasis of cholangiocarcinoma. 32nd EORTC-NCI-AACR symposium: molecular targets and cancer therapeutics. Oct 24-25, 2020 (Virtual)

27.  Chen CL, Chang YC, Hsiao M. Rab GTPases Accelerates GLUT4 Translocation in Colorectal Cancer Progression by Insulin/IGF system. 2020 Annual Meeting at Experimental Biology. San Diego, CA, USA. (Virtual)

28.  Chang YC, Hsiao M. Overexpression of Solute Carrier Family in Ambient Particulate Matter Exposure Fibroblasts Enhances Lung Cancer Progression. 2020 Annual Meeting at Experimental Biology. San Diego, CA, USA. (Virtual)

29.  Tien CP, Chang YC, Hung SC, Hsiao M. PM2.5 Activates Sirtuin-SREBP1-PIR Axis to Induce Pulmonary Fibroblast Inflammation. 2019 Annual Meeting at Experimental Biology. Orlando, FL, USA. April 6-9, 2019

30.  Tseng YW, Chang YC, Hsiao M. Translocation and Targeting of PGK1 to HTATSF1 Regulate Cancer Cell Metastatic Ability. 2019 Annual Meeting at Experimental Biology. Orlando, FL, USA. April 6-9, 2019

31.  Chen CL, Chang YC, Hsiao M. Dystrophin Promotes Colorectal Carcinoma Metastasis and Exosome Secretion via Protein-Protein Interaction with Rab GTPasse 3C. 2019 Annual Meeting at Experimental Biology. Orlando, FL, USA. April 6-9, 2019

32.  Chang YC, Hsiao M. V-ATPase Family Regulates Lysosomal Exocytosis and Neutralizes with Tumor-Infiltrating Lymphocytes for Glioblastoma Cells. 2019 AACR Annual meeting. Atlanta, GA, USA. March 29-April 3, 2019

33.  Chang YC, Hsiao M*. Glycolysis enzyme screenings identify non-glycolytic function of aldolase A that interacts and alters F-actin dynamics to promote lung cancer metastasis. ELCC 2018 European Lung Cancer Congress, Geneva, Switzerland. April 11-14. 2018.

34.  Tsai, HF, Chang YC, Hsiao M*. Aldolase A triggers Oct4 activation to acquire lung cancer stem cell phenotypes through non-enzymatic functions. United States & Canadian Academy of Pathology (USCAP) Annual Meeting, Vancouver, Canada, March 17-23, 2018

35.  Chang YC, Hsiao M. Hypoxia-mediated Translational Control of Hypoxia Inducible Factor 1 Alpha through Aldolase A Feedback Regulated in Lung Carcinogenesis. 2016 Translational Control of Cancer: A New Frontier in Cancer Biology and Therapy, San Francisco, CA, USA

36.  Chang YC, Hsiao M. Therapeutic Targeting of Aldolase A to Inhibit Metastatic Ability via Glycolysis-independent Mechanism in Lung Cancer. 2016 1st Presentation of Investigators, Students and Academicians annual meeting, Houston, TX, USA

37.  Chang YC, Jan YH, Su CY, Hsiao M. PLD1 Rather Than PLD2 Regulates Lung Cancer Metastasis Is Dependent on Non-enzymatic Function of Aldolase A. 2015 The 23th Symposium on Recent Advances in Cellular and Molecular Biology, Kenting, Taiwan

38.  Chang YC, Hsiao M. Glucose Transporter 4 Drives Head and Neck Cancer Metastasis through TRIM24 Signaling Pathway. 2016 NDMC retreat, Ilan, Taiwan

39. Chang YC, Jan YH, Yang YF, Su CY, Lai TC, Hsiao M. Aldolase A induces invasion/metastasis of lung cancer through modulating HIF1-α and is a marker for poor clinical outcome. 2014 American Association for Cancer Research Annual Meeting, San Diego, CA, USA. 

Invited Lectures

1.     The insights of multi-omics in cancer biology and its outlook in radiation therapy. Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Oct 14, 2022.

2. Regorafenib Inhibits Epithelial-Mesenchymal Transition and Suppresses Cholangiocarcinoma Metastasis via YAP1-AREG axis. Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming Chiao Tung University, May 17, 2022.

3.          Omics-Based Platforms: Current Status and Potential Use for Cholangiocarcinoma. The Gastroenterological Society of Taiwan. Linkou Chang Gung Memorial Hospital. Dec. 12, 2020.

4.          Roles of Aldolase Family Genes in Human Cancers and Metabolic Reprogramming, Kaohsiung Veterans General Hospital, May. 8, 2020

5.          Metabolic Reprogramming in Carcinogenesis and in Human Diseases, Kaohsiung Medical University, Dec. 9, 2019

6.          Multi-Omics approaches to identify alterations of metabolic genes in cancer, Kaohsiung Medical University, Dec. 24, 2018

7.          Metabolic Events in Cancer, China Medical University, Sep. 29, 2018.

8.          In-silico and In-tissue Array-based Discovery of Metabolic Reprogramming in Human Cancer, Kaohsiung Medical University, May. 22, 2017

9.          Array-based Discovery and Validation of New Cancer Biomarkers, National Yang-Ming University, March. 29, 2017

10.  ALDOA Promotes Metastatic Progression via Glycolysis-independent Protein-Protein Interaction with γ-Actin, Academia Sinica. Dec. 27, 2016

11.  Therapeutic targeting of aldolase A/gamma-actin interaction inhibits lung cancer metastasis, National Defense Medical Center, Sep. 9, 2016

12.  ALDOA Promotes Metastatic Progression via Glycolysis-independent Protein-Protein Interaction with γ-Actin, National Cheng-Kung University, April. 14, 2016

13.  Aldolase A in lung cancer, Taipei Medical University, March. 6, 2016

14.  High-throughput Tissue Array-based Screens Identifies Metabolic Reprogramming in Lung Cancer Cells to Promote Metastasis and Predicts Poor Outcome, Metabolic mini-symposium, National Yang-Ming University, Nov. 27, 2015.