Publications

Editorials

1. A Sharma, M Mishra, K Sharan#. Editorial: Developmental origin of diseases: a special focus on the parental contribution towards offspring’s adult health. Frontiers in Endocrinology. 2023, 14, 1196653

2. K Sharan#. Editorial: Vascular and skeletal crosstalk in health and disease. Frontiers in Endocrinology. 2022, 3, 1084940

Patents

1. Novel flavonol compounds, a bioactive extract/fraction from Ulmus wallichiana and its compounds for prevention for treatment of osteo-health related disorders. (WO/2009/110003) US patent 8669232 B2

2. Novel flavonol compounds, compositions thereof and method for treating bone disorders. ES2546864T3

3. Ulmoside-A-derived compound from Ulmus Wallichiana Planchon useful for prevention or cure of metabolic diseases. EP3027633B1

Research/Reviews Articles

1. Kanwate BW, Patel K, Karkal SS, Rajoriya D, Sharan K, TG Kudre. Production of Antioxidant, Angiotensin-Converting Enzyme Inhibitory and Osteogenic Gelatin Hydrolysate from Labeo rohita Swim Bladder. Marine Biotechnology. 2024, 1-17. IF-3

2. Bose S, Sharan K#. Effect of probiotics on postmenopausal bone health: a preclinical meta-analysis. British Journal of Nutrition. 2023, 1-14. doi:10.1017/S0007114523002362. IF-3.6

3. Singh P, Gollapalli K, Mangiola S …….. Sharan K…… Yadav VK. Taurine deficiency as a driver of aging. Science. 2023, 380 (6649), eabn9257. IF-63.7

4. Patel K, Mangu SR, Sukhdeo SV, Sharan K#. Sesamol improves bone mass in ovary intact growing and adult rats but accelerates bone deterioration in the ovariectomized rats. The Journal of Nutritional Biochemistry. 2023, 109384. IF-6.05

5. Vamadeva SG, Patel K, Mangu SR, Ellur G, Sukhdeo SV, Sharan K#. Maternal omega-3 LC-PUFA supplementation programs an improved bone mass in the offspring with a more pronounced effect in females than males at adulthood. The Journal of Nutritional Biochemistry. 2022, 109245. IF-6.05

6. Vamadeva SG, Bhattacharyya N, Sharan K#. Maternal Plasma Glycerophospholipids LC-PUFA Levels Have a Sex-Specific Association with the Offspring’s Cord Plasma Glycerophospholipids-Fatty Acid Desaturation Indices at Birth. International Journal of Environmental Research and Public Health. 2022; 19 (22), 14850. IF-4.614

7. Mangu SR, Patel K, Sukhdeo SV, Savitha MR, Sharan K#. Maternal high cholesterol diet negatively programs offspring bone development and downregulates hedgehog signaling in osteoblasts. Journal of Biological Chemistry. 2022; 102324. IF-5.49

8. Pahwa H, Sharan K#. Food and nutrition as modifiers of the immune system: A mechanistic overview. Trends in Food Science & Technology. 2022; 123, 393-403. IF-16

9. K Patel, SR Mangu, SV Sukhdeo, Sharan K#. Ethanolic extract from the root and leaf of Sida cordifolia promotes osteoblast activity and prevents ovariectomy-induced bone loss in mice. Phytomedicine. 2022; 99, 154024. IF-5.34

10. Shivarudrappa AH, Sharan K, Ponesakki G. Lutein activates downstream signaling pathways of unfolded protein response in hyperglycemic ARPE-19 cells. European Journal of Pharmacology. 2022; 914, 174663. IF-4.43

11. Ellur G, Sukhdeo SV, Khan MT, Sharan K#. Maternal high protein-diet programs impairment of offspring’s bone mass through miR-24-1-5p mediated targeting of SMAD5 in osteoblasts. Cellular and Molecular Life Sciences. 2021; 78 (4), 1729-1744 doi.org/10.1007/s00018-020-03608-6. IF-9.26

12. Pahwa H, Khan MT, Sharan K#. Hyperglycemia impairs osteoblast cell migration and chemotaxis due to a decrease in mitochondrial biogenesis. Molecular and Cellular Biochemistry. 2020; 469:109–118. IF-3.4

13. Gavvaa C, Patel K, Kudre T, Sharan K, Nandini CD. Glycosaminoglycans from fresh water fish processing discard - Isolation, structural characterization, and osteogenic activity. International Journal of Biological Macromolecules. 2020; 145, 558-567. IF-6.95

14. Ali SJ, Ellur G, Patel K, Sharan K#. Chlorpyrifos Exposure Induces Parkinsonian Symptoms and Associated Bone Loss in Adult Swiss Albino Mice. Neurotoxicity Research. 2019; 36 (4), 700-711. IF-3.91

15. Ali SJ, Ellur G, Khan MT, Sharan K#. Bone loss in MPTP mouse model of Parkinson's disease is triggered by decreased osteoblastogenesis and increased osteoclastogenesis. Toxicology and applied pharmacology. 2019; 363, 154-163. IF-4.22

16. Srivastav A, Changkija B, Sharan K, Nagar GK, Bansode FW. Influence of Dutasteride and Nifedipine on CatSper gene expression in epididymis of mice. Reproduction. 2018; REP-17-0664. IF-3.91

17. Deepa B, GS Joseph, Ellur G, Patel K , Pamisetty A, Mittal M, China SP, Singh RP and Sharan K#. Stimulation of liver IGF-1 expression promotes peak bone mass achievement in growing rats: A study with Pomegranate seed oil. J Nutr Biochem. 2018; 52, 18-26. IF-6.05

18. Lewis K*, Sharan K*, Takumi T, Yadav VK. (2017) Skeletal Site-specific Changes in Bone Mass in a Genetic Mouse Model for Human 15q11-13 Duplication Seen in Autism. Scientific Reports. 2017; 7:1. doi:10.1038/s41598-017-09921-8.  *- First authors IF-4.38

19. Sharan K, Lewis K, Furukawa T, Yadav VK. Regulation of bone mass through pineal-derived melatonin-MT2 receptor pathway. J Pineal Research. 2017; 63:e12423.  https://doi.org/10.1111/jpi.12423. IF- 13.01

20. Sharan K and Yadav VK. Hypothalamic control of bone metabolism. Best Practice & Research Clinical Endocrinology & Metabolism. 2014; 28 (5), 713-723. IF-4.69

21. Roman-Garcia P, Quiros-Gonzalez I, Mottram L, Lieben L, Sharan K, Wangwiwatsin A, Tubio J, Lewis K, Wilkinson D, Santhanam B, Sarper N, Clare S, Vassiliou GS, Velagapudi VR, Dougan G and Yadav VK. Vitamin B₁₂-dependent taurine synthesis regulates growth and bone mass. J Clin Invest. 2014; 1;124(7):2988-3002. IF-14.81

22. Khan MP, Mishra JS, Sharan K, Yadav M, Singh AK, Srivastava A, Kumar S, Bhaduaria S, Maurya R, Sanyal S, and Chattopadhyay N. A novel flavonol C-glucoside preserves bone mineral density, microarchitecture and biomechanical properties in the presence of glucocorticoid by promoting osteoblast survival: a comparative study with human parathyroid hormone. Phytomedicine. 2013; 20 (14), 1256-1266. IF-5.34

23. Khan K., Sharan K, Swarnkar G, Chakravarti B, Mittal M, Barbhuyan TK, China SP, Khan MP, Nagar GK, Yadav D, Dixit P, Maurya R, and Chattopadhyay N. Positive skeletal effects of cladrin, a naturally occurring dimethoxydaidzein, in osteopenic rats that were maintained after treatment discontinuation. Osteoporosis Int. 2012. 24(4): p. 1455-70. IF-4.51

24. Khan K, Singh A, Mittal M, Sharan K, Singh N, Dixit P, Sanyal S, Maurya R, and Chattopadhyay N. [6]-Gingerol induces bone loss in ovary intact adult mice and augments osteoclast function via the transient receptor potential vanilloid 1 channel. Mol Nutr Food Res. 2012 56(12): p. 1860-73. IF-5.91

25. Balaramnavar VM, Khan IA, Siddiqui JA, Khan MP, Chakravarti B, Sharan K, Swarnkar G, Rastogi N, Siddiqui HH, Mishra DP, Chattopadhyay N, and Saxena AK. Identification of novel 2-((1-(benzyl(2-hydroxy-2-phenylethyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamoyl) benzoic acid analogues as BMP-2 stimulators. J Med Chem. 2012 55(19): p. 8248-59. IF-7.45

26. Siddiqui JA, Swarnkar G, Sharan K, Chakravarti B, Gautam AK, Rawat P, Kumar M, Gupta V, Manickavasagam L, Dwivedi AK, Maurya R and Chattopadhyay N.  A Naturally Occurring Rare Analog of Quercetin Promotes Peak Bone Mass Achievement and Exerts Anabolic Effect on Osteoporotic Bone. Osteoporosis International. 2011; 22(12):3013-27. IF-4.51

27. Sharan K, Mishra JS, Swarnkar G, Siddiqui JA, Khan K, Rashmi K, Maurya R, Sanyal S, Chattopadhyay N. A novel quercetin analog from a medicinal plant promotes peak bone mass achievement, bone healing after injury and exerts anabolic effect on osteoporotic bone: The role of aryl hydrocarbon receptor as a mediator of osteogenic action. J Bone Miner Res. 2011; 26 (9), 2096-2111. IF-6.74

28. Swarnkar G, Sharan K, Siddiqui JA, Chakravarti B, Rawat P, Kumar M, Arya KR, Maurya R, Chattopadhyay N. Studies on the effects of a novel compound, (2S,3S)-aromadendrin-6-C-β-D-glucopyranoside isolated from the steam-bark of Ulmus Wallichaiana Planchon on bone cells. Eur J Pharmacol. 2011 May 11;658(2-3):65-73. IF-4.43

29. Siddiqui JA, Sharan K, Swarnkar G, Rawat P, Kumar M, Manickavasagam L, Maurya R, Pierroz D, Chattopadhyay N. Quercetin-6-C-b-D-glucopyranoside isolated from Ulmus Wallichiana-planchon is more potent than quercetin in inhibiting osteoclastogenesis and mitigating ovariectomy-induced bone loss in rats. Menopause. 2011 Feb;18(2):198-207. IF-2.95

30. Swarnkar G, Sharan K, Siddiqui JA, Mishra JS, Khan K, Khan MP, Gupta V, Rawat P, Maurya R, Dwivedi AK, Sanyal S, and Chattopadhyay N. A naturally occurring naringenin derivative exerts potent bone anabolic effects by mimicking oestrogen action on osteoblasts. Br J Pharmacol, 2011. 165(5): p. 1526-42. IF-8.74

31. Tyagi AM, Srivastava K, Sharan K, Yadav D, Maurya R, Singh D. Daidzein Prevents the Increase in CD4+CD28null T Cells and B Lymphopoesis in Ovariectomized Mice: A Key Mechanism for Anti-Osteoclastogenic Effect. PLoS One, 2011. 6(6): p. e21216. IF-3.24

32. Siddiqui JA, Swarnakr G, Sharan K, Chakravarti B, Sharma G, Rawat P, Kumar M, Pierroz D, Maurya R, Chattopadhyay N. 8,8”-biapigeninyl stimulates osteoblast functions and inhibits osteoclast and adipocyte functions: osteoprotective action of 8,8”-biapigeninyl in ovariectomized mice. Mol Cell Endocrinol 2010; 323:256-67. IF-4.1

33. Sharan K, Swarnkar S, Siddiqui JA, Kumar A, Rawat P, Kumar M, Nagar GK, Manickavasagam L, Singh SP, Mishra G, Wahajuddin, Jain GK, Maurya R, Chattopadhyay N. A Novel flavonoid, 6-C-b-D-glucopyranosyl-(2S,3S)-(+)-3’,4’,5,7-tetrahydroxyflavanone, isolated from Ulmus wallichiana-planchon mitigates ovariectomy-induced osteoporosis in rats. Menopause 2010; 17:577-86. IF-2.95

34. Sharan K, Siddiqui JA, Swarnkar S, Tyagi AM, Kumar A, Rawat P, Kumar M, Arya KR, Manickivasagam L, Jain GK, Maurya R, Chattopadhyay N. Extract and fraction of Ulmus wallichiana planchon promote peak bone achievement and have non-estrogenic osteoprotective effect. Menopause 2010; 17:393-402. IF-2.95

35. Rawat P, Kumar M, Sharan K, Chattopadhyay N, Maurya R. Ulmosides A and B: Flavonoid 6-C-glycosides from Ulmus wallichiana, stimulating osteoblast differentiation assessed by alkaline phosphatase. Bioorganic & Medicinal Chemistry Letters. 2009; 15;19(16):4684-7. IF-2.82

36. Sharan K*, Siddiqui JA, Swarnkar G, Maurya R, Chattopadhyay N. Role of phytochemicals in the prevention of menopausal bone loss: evidence from in vitro and in vivo, human interventional and pharma-cokinetic studies. Curr Med Chem 2009; 16:1138-1157. *-Corresponding author. IF- 4.53

37. Sharan K, Siddiqui JA, Swarnkar G, Chattopadhyay N. Role of calcium-sensing receptor in bone biology. Indian J Med Res March 2008; 127: 274-286. IF- 2.37