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immunotherapy drugs that can help a person's immune system fight the cancer. 12 Immune checkpoint inhibitors: Cancer cells can sometimes avoid being attacked by the body’s immune system by using certain “checkpoints” that normally keep the immune system in check. For example, cancer cells often have a lot of a protein called PD-L1 on their surface that helps them evade the immune system. New drugs that block the PD-L1 protein, or the corresponding PD-1 protein on immune cells called T cells, can help the immune system recognize the cancer cells and attack them. Some of these drugs are now approved for use in advanced NSCLC. Studies are currently evaluating if giving an immunotherapy drug along with radiation therapy in people who can't have surgery, can improve shrinkage of the tumor and maybe help people live longer. Hyperlinks 1. www.cancer.org/healthy/stay-away-from-tobacco/guide-quitting-smoking.html 2. www.cancer.org/cancer/cancer-causes/radiation-exposure/radon.html 3. www.cancer.org/cancer/cancer-causes/diesel-exhaust-and-cancer.html www.cancer.org/healthy/eat-healthy-get-active/acs-guidelines-nutrition-physicalactivity-cancer-prevention.html 4. 5. www.cancer.org/cancer/lung-cancer/detection-diagnosis-staging/detection.html 6. www.cancer.org/cancer/lung-cancer/treating-non-small-cell/targeted-therapies.html 7. www.cancer.org/cancer/lung-cancer/treating-small-cell/radiation-therapy.html References Ahn MJ, Kim DW, Cho BC, Kim SW, Lee JS, Ahn JS, et al. Activity and safety of AZD3759 in EGFR-mutant non-small-cell lung cancer with CNS metastases (BLOOM): a phase 1, open-label, dose-escalation and dose-expansion study. Lancet Respir Med. 2017 Nov;5(11):891-902. Knight BS, Crosbie PA, Balata H, Chudziak J, Hussell T, Dive C. Progress and prospects of early detection in lung cancer. Open Biol. 2017;7(9):170070. KEYTRUDA is a medicine that may treat certain cancers by working with your immune system. KEYTRUDA can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. These problems may happen any time during treatment or even after your treatment has ended.Call or see your doctor right away if you develop any symptoms of the following problems or these symptoms get worse:Lung problems (pneumonitis). Symptoms of pneumonitis may include shortness of breath, chest pain, or new or worse cough.Intestinal problems (colitis) that can lead to tears or holes in your intestine. Signs and symptoms of colitis may include diarrhea or more bowel movements than usual; stools that are black, tarry, sticky, or have blood or mucus; or severe stomach-area (abdomen) pain or tenderness.Liver problems, including hepatitis. Signs and symptoms of liver problems may include yellowing of your skin or the whites of your eyes, nausea or vomiting, pain on the right side of your stomach area (abdomen), dark urine, or bleeding or bruising more easily than normal.Hormone gland problems (especially the thyroid, pituitary, adrenal glands, and pancreas). Signs and symptoms that your hormone glands are not working properly may include rapid heartbeat, weight loss or weight gain, increased sweating, feeling more hungry or thirsty, urinating more often than usual, hair loss, feeling cold, constipation, your voice gets
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