FLIM

Fluorescence lifetime microscopy (FLIM)

Fluorescence lifetime is a time constant of fluorescence decay, which is a kind of spontaneous emission. By measuring the fluorescence lifetime, bio-chemical changes in the micro-environment can be detected.

Analog mean delay (AMD)

By measuring the analog mean delay of the pulse, we developed a method, so-called analog mean delay (AMD) method, that can measure the fluorescence lifetime more efficiently and faster than the conventional method. Using the AMD method, we conducted a study to measure changes of the ratio of neutral to polar lipid in cells. In addition, using metal-induced energy transfer phenomenon and bi-exponential analysis, we measured cell-substance distance in a large field of view.

We cooperated with companies to transfer this technology, and through cooperation with Switzerland, we are developing next-generation medical equipment for early diagnosis of retinal diseases by commercializing it in a modular form.