Publication list (pubmed: JONCKHEERE N)
orcid.org/0000-0002-0496-0661
ORCID : https://orcid.org/0000-0002-0496-0661
2023
1. Quilbé A, Mustapha R, Duchêne B, Kumar A, Werkmeister E, Leteurtre E, Morales O, Jonckheere N, Van Seuningen I, Delhem N. Frontiers in Immunology 2023, doi: 10.3389/fimmu.2023.1267279
2. Jannin A, Dessein AF, Do Cao C, Vantyghem MC, Chevalier B, Van Seuningen I, Jonckheere N*, Coppin L*. Pancreatic neuroendocrine tumors and metabolism: What do we know after Omic approaches? Frontiers in Endocrinology 2023, 16;14:1248575.
2022
3. Auwercx, J.; Kischel, P.; Lefebvre, T.; Jonckheere, N.; Vanlaeys, A.; Guénin, S.; Radoslavova, S.; Van Seuningen, I.; Ouadid-Ahidouch, H.; Kocher, H.M.; Dhennin-Duthille, I.; Gautier, M. TRPM7 Modulates Human Pancreatic Stellate Cell Activation. Cells 2022, 11, 2255.
4. Foulon A, Rybarczyk P, Jonckheere N, Brabencova E, Sevestre H, Ouadid-Ahidouch H, Rodat-Despoix L. Inositol (1,4,5)-Trisphosphate Receptors in Invasive Breast Cancer: A New Prognostic Tool? Int J Mol Sci. 2022 Mar 9;23(6):2962. doi: 10.3390/ijms23062962
5. Bachir EH, Poiraud C, Paget S, Stoup N, Moghrabi SE, Duchêne B, Jouy N, Bongiovanni A, Tardivel M, Weiswald LB, Vandepeutte M, Beugniez C, Escande F, Leteurtre E; OrgaRES consortium, Poulain L, Lagadec C, Pigny P, Jonckheere N, Renaud F, Truant S, Van Seuningen I, Vincent A. A new pancreatic adenocarcinoma-derived organoid model of acquired chemoresistance to FOLFIRINOX: first insight of the underlying mechanisms. Biol Cell 2022, 114(1):32-55. doi: 10.1111/boc.202100003. Epub 2021 Oct 16. IF=3.9
6. Raab S, Very N, Duchêne B, Rybarczyk P, Jonckheere N, El Yazidi-Belkoura I, Lefebvre T. Evaluation of the expression of fatty acid synthase and O-GlcNAc transferase in patients with liver cancer by exploration of transcriptome databases and experimental approaches. Oncology letters. 2022 Apr;23(4):105.
2021
7. Boukrout N, Souidi M, Lahdaoui F, Duchêne B, Neve B, Coppin L, Leteurtre E, Torrisani J, Van Seuningen I and Jonckheere N. Antagonistic Roles of the Tumor Suppressor miR-210-3p and Oncomucin MUC4 Forming a Negative Feedback Loop in Pancreatic Adenocarcinoma. Cancers (Basel). 2021, 13(24):6197. doi: 10.3390/cancers13246197.
8. Stoup N, Liberelle M, Schulz C, Cavdarli S, Vasseur R, Magnez R, Lahdaoui F, Skrypek N, Peretti F, Frénois F, Thuru X, Melnyk P, Renault N, Jonckheere N, Lebègue N, Van Seuningen I. The EGF Domains of MUC4 Oncomucin Mediate HER2 Binding Affinity and Promote Pancreatic Cancer Cell Tumorigenesis. Cancers (Basel). 2021 Nov 16;13(22):5746. doi: 10.3390/cancers13225746. IF=6.6
2020
9. Jonckheere N, Auwercx J, Hadj Bachir E, Coppin L, Boukrout N, Vincent A, Neve B, Gautier M, Treviño V, Van Seuningen I. Unsupervised Hierarchical Clustering of Pancreatic Adenocarcinoma Dataset from TCGA Defines a Mucin Expression Profile that Impacts Overall Survival. Cancers (Basel). 2020 Nov 9;12(11):3309. IF=6.1
10. Siebert M, Ribeiro-Parenti L, Nguyen ND, Hourseau M, Duchêne B, Humbert L, Jonckheere N, Nuel G, Chevallier JM, Duboc H, Rainteau D, Msika S, Kapel N, Couvelard A, Bado A, Le Gall M. Long-term consequences of one anastomosis gastric bypass on esogastric mucosa in a preclinical rat model Scientific Reports. 2020 en révision IF=4.1
11. Liberelle M, Jonckheere N, Melnyk P, Van Seuningen I, Lebegue N. EGF-containing Membrane-bound Mucins: a hidden ErbB2 targeting pathway? Journal of Medicinal Chemistry. 2020 en révision IF=6.05
2018
12. Jonckheere N, Van Seuningen I. Integrative analysis of the cancer genome atlas and cancer cell lines encyclopedia large-scale genomic databases: MUC4/MUC16/MUC20 signature is associated with poor survival in human carcinomas. J Transl Med. 2018 Sep 20;16(1):259. doi: 10.1186/s12967-018-1632-2. IF=4.2
13. Drubay V*, Skrypek N*, Cordiez L*, Vasseur R, Schulz C, Boukrout N, Duchêne B, Coppin L, Van Seuningen I, Jonckheere N. TGF-βRII knock-down in pancreatic cancer cells promotes tumor growth and gemcitabine resistance. Importance of STAT3 phosphorylation on S727. Cancers. 2018 10(8). pii: E254. IF=6.2
2017
14. Lahdaoui F, Messager M, Vincent A, Hec F, Gandon A, Warlaumont M, Renaud F, Leteurtre E, Piessen G, Jonckheere N, Mariette C, Van Seuningen I. Depletion of MUC5B mucin in gastrointestinal cancer cells alters their biological properties: Implication of the Wnt/β-catenin pathway. Biochem J. 2017; 474(22):3733-3746 IF=3.8
15. Porte R, Van Maele L, Muñoz-Wolf N, Foligné B, Dumortier L, Tabareau J, Cayet D, Gosset P, Jonckheere N, Van Seuningen I, Chabalgoity JA, Simonet M, Lamkanfi M, Renauld JC, Sirard JC, Carnoy C. Flagellin-mediated protection against intestinal Yersinia pseudotuberculosis infection does not require interleukin-22. Infection and Immunity 2017 Jan 26;85(2). pii: e00806-16. IF= 3.2
2015
16. Vasseur R, Skrypek N, Duchêne B, Renaud F, Martinez-Maqueda D, Vincent A, Porchet N, Van Seuningen I and Jonckheere N. The mucin MUC4 is a transcriptional and post-transcriptional target of K-ras oncogene in pancreatic cancer. Implication of MAPK/AP-1, NF-<kappa>B and RalB signalling pathways. BBA – Gene Regulatory Mechanisms 2015, 1849(12):1375-1384. IF=5.4
17. Tréhoux S, Lahdaoui F, Delpu Y, Renaud F, Leteurtre E, Torrisani J, Jonckheere N and Van Seuningen I, Micro-RNAs miR-29a and miR-330-5p function as tumor suppressors by targeting the MUC1 mucin in pancreatic cancer cells. BBA - Molecular Cell Research. 2015 1853(10 Pt A):2392-403. IF=5.1
18. Skrypek N, Vasseur R, Vincent A, Duchêne B, Van Seuningen I and Jonckheere N. The oncogenic receptor ErbB2 modulates gemcitabine and irinotecan/SN-38 chemoresistance of human pancreatic cancer cells via hCNT1 transporter and multidrug-resistance associated protein MRP-2. Oncotarget 2015, 6(13):10853-67. IF=5.0
19. Desurmont T, Skrypek N, Duhamel A, Jonckheere N, Millet G, Leteurtre E, Gosset P, Duchene B, Ramdane N, Hebbar M, Van Seuningen I, Pruvot FR, Huet G and Truant S. CXCR2 and CXCL7 expression in liver metastases from colon cancer are correlated to shorter disease-free and overall survival. Cancer Sci. 2015 doi: 10.1111/cas.12603. IF=3.9
20. Tréhoux S, Duchêne B, Jonckheere N and Van Seuningen I. The MUC1 oncomucin regulates pancreatic cancer cell biological properties and chemoresistance. Implication of p42-44 MAPK, Akt, Bcl-2 and MMP13 pathways. Biochem Biophys Res Commun, 2015, 456(3):757-62. IF=2.4
21. Vincent A, Kazmierczak C, Duchêne B, Jonckheere N, Leteurtre E, Van Seuningen I Cryosectioning the intestinal crypt-villus axis: an ex vivo method to study the dynamics of epigenetic modifications from stem cells to differentiated cells. Stem Cell Research 2015 14(1):105-113. IF=3.9
22. Lahdaoui F, Delpu Y, Vincent A, Renaud F, Messager M, DuchêneB, Leteurtre E, Mariette C, Torrisani J, Jonckheere N and Van Seuningen I. miR-219-1-3p is a negative regulator of the mucin MUC4 expression and is a tumor suppressor in pancreatic cancer. Oncogene. 2015, 34(6):780-8. doi: 10.1038/onc.2014.11 IF=7.9
2014
23. Gronnier C, Bruyère E, Lahdaoui F, Jonckheere N, Perrais M, Leteurtre E, Piessen G, Mariette C, Van Seuningen I. The MUC1 mucin regulates the tumorigenic properties of human esophageal adenocarcinomatous cells. BBA - Molecular Cell Research. 2014 1843(11):2432-2437. IF=5.0
24. Perrais M, Rousseaux C, Ducourouble MP, Courcol C, Vincent P, Jonckheere N and Van Seuningen I. Helicobacter pylori urease and flagellin alter mucin gene expression in human gastric cancer cells. Gastric Cancer. 2014 17(2):235-46. IF=3.7
2013
25. Skrypek N, Duchêne B, Hebbar M, Leteurtre E, Van Seuningen I and Jonckheere N. The MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family. Oncogene, 2013 32(13):1714-1723. IF=8.6
2012
26. Jonckheere N, Vincent A, Ansart-Franquet H, Witte-Bouma J, Korteland-van Male A, Leteurtre E, Renes IB, and Van Seuningen I. GATA-4/-6 and HNF-1/-4 families of transcription factors play an important role in the spatio-temporal expression of the Muc5ac mucin in the stomach. BBA gene regulatory mechanisms. 2012, 1819(8):869-76..
27. Jonckheere N, Skrypek N, Merlin J, Dessein AF, Dumont P, Harris A, Desseyn JL, Susini C Frénois F, and Van Seuningen I. The mucin MUC4 and its membrane partner ErbB2 regulate biological properties of human CAPAN-2 pancreatic cancer cells via different signaling pathways. PLoS one, 2012;7(2):e32232.
28. Vincent DF, Gout J, Chuvin N, Arfi V, Pommier R, Bertolino P, Jonckheere N, Ripoche D, Kaniewski B, Martel S, Langlois JB, Goddard Léon S, Colombe A, Janier M, Van Seuningen I, Valcourt U, Treilleux I, Dubus P, Bardeesy N and Bartholin L. TIF1g and SMAD4 act in Separate Pathways to Suppress Kras-driven Pancreatic Tumorigenesis in Mouse. Am J Pathol, 180(6):2214-21
2011
29. Bruyère E, Jonckheere N, Frénois F, Mariette C, Van Seuningen I. The MUC4 membrane-bound mucin regulates esophageal cancer cell proliferation and migration properties: Implication for S100A4 protein. Biochem Biophys Res Commun, 2011, 23;413(2):325-9.
30. Jonckheere N, Renes IB, Velghe A, Ducourouble MP, Copin MC, and Van Seuningen I. The Muc5b mucin gene is transcriptionally regulated by transcription factors TTF-1 and GATA-6 in epithelial cancer cell lines. FEBS Journal, 2011, 278(2):282-94
2010
31. Dessein AF, Stechly L, Jonckheere N, Dumont P, Monté D, Leteurtre E, Truant S, Pruvot FR, Kerckaert JP, Hebbar M, Lecellier CH, Lessufleur T, Dessein R, Grard G, Dejonghe MJ, De Launoit Y, Furuichi Y, Prévost G, Porchet N, Gespach C and Huet G. Autocrine induction of invasive and metastatic phenotypes by the MIF-CXCR4 axis in drug resistant human colon cancer cells. Cancer Res 2010, 70(11):4644-54
2009
32. Jonckheere N, Fauquette V, Stechly L, Saint-Laurent N, Aubert S, Susini C, Huet G, Van Seuningen I and Pigny P. Tumour growth and resistance to gemcitabine of pancreatic cancer cells are decreased by AP-2α over-expression. British Journal of Cancer, Aug 18;101(4):637-44.
2008
33. Jonckheere N, Mayes E, Shih HP, Li B, Lioubinski O, Dai, X and Sander M. Analysis of mPygo2 mutant mice reveals a requirement for mesenchymal Wnt signaling in pancreatic growth and differentiation. Dev Biol. 2008 Jun 15;318(2):224-35.
2007
34. Jonckheere N, Vincent A, Perrais M, Ducourouble MP, Male AK, Aubert JP, Pigny P, Carraway KL, Freund JN, Renes IB, Van Seuningen I. The human mucin MUC4 is transcriptionally regulated by caudal-related homeobox, hepatocyte nuclear factors, forkhead box A, and GATA endodermal transcription factors in epithelial cancer cells. J Biol Chem. 2007 Aug 3;282(31):22638-50.
35. Piessen G, Jonckheere N, Vincent A, Hemon B, Ducourouble MP, Copin MC, Mariette C, Van Seuningen I. Regulation of the human mucin MUC4 by taurodeoxycholic and taurochenodeoxycholic bile acids in oesophageal cancer cells is mediated by hepatocyte nuclear factor 1alpha. Biochem J. 2007 Feb 15;402(1):81-91.
2006
36. Rat E, Billaut-Laden I, Allorge D, Lo-Guidice JM, Tellier M, Cauffiez C, Jonckheere N, van Seuningen I, Lhermitte M, Romano A, Gueant JL, Broly F. Evidence for a functional genetic polymorphism of the human retinoic acid-metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida. Birth Defects Res A Clin Mol Teratol. 2006 Jun;76(6):491-8.
2005
37. Fauquette V, Perrais M, Cerulis S, Jonckheere N, Ducourouble MP, Aubert JP, Pigny P and Van Seuningen I. The antagonistic regulation of MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells. Implications for the proliferation/differentiation balance in the cells. Biochem J 2005 Feb 15;386(Pt 1):35-45.
2004
38. Jonckheere N, Perrais M, Mariette C, Batra SK, Aubert JP, Pigny P and Van Seuningen I. A role for human MUC4 mucin gene, the ErbB2 ligand, as a target of TGF-b in pancreatic carcinogenesis. Oncogene. 2004 Jul 29;23(34):5729-38.
39. van der Sluis M, Melis MH, Jonckheere N, Ducourouble MP, Büller HA, Renes IB, Einerhand AWC and Van Seuningen I. The murine Muc2 mucin gene is transcriptionally regulated by the zinc-finger GATA-4 transcription factor in intestinal cells. Biochem Biophys Res Commun, 2004 Dec 17;325(3):952-960
40. Jonckheere N, Van der Sluis M, Velghe A, Buisine MP, Sutmuller M, Ducourouble MP, Pigny P, Büller HA, Aubert JP, Einerhand AWC and Van Seuningen I. Transcriptional activation of the murine Muc5ac mucin gene in epithelial cancer cells by TGF-b/Smad4 signaling pathway is potentiated by Sp1. Biochem J. 2004 Feb 1; 377(3): 797-808.
41. Mariette C, Perrais M, Leteurtre E, Jonckheere N, Hémon B, Pigny P, Batra S, Aubert JP, Triboulet JP and Van Seuningen I. Transcriptional regulation of human mucin MUC4 by bile acids in oesophagus cancer cells is promoter dependent and involves activation of phosphatidylinositol 3-kinase signalling pathway. Biochem J. 2004 Feb 1; 377(3): 701-8.
2003
42. Mesquita P, Jonckheere N, Almeida R, Ducourouble MP, Serpa J, Silva E, Pigny P, Silva FS, Reis C, Silberg D, Van Seuningen I and David L. Human MUC2 mucin gene is transcriptionally regulated by Cdx homeodomain proteins in gastrointestinal carcinoma cell lines. J Biol Chem.2003 Dec 19;278(51):51549-56.
Jonckheere N, Lahdaoui F, Van Seuningen I. Targeting MUC4 in pancreatic cancer: miRNAs. Oncoscience. 2015; 2(10):799-800.
Jonckheere N, Vincent A, Van Seuningen I. Of autophagy and in vivo pancreatic carcinogenesis: the p53 status matters! Clin Res Hepatol Gastroenterol. 2014, S2210-7401(14)00104-1.
Jonckheere N, Van Seuningen I. Comment on: Functional MUC4 suppresses epithelial-mesenchymal transition in lung adenocarcinoma metastasis. Gao L, Liu J, Zhang B, Zhang H, Wang D, Zhang T, Liu Y, Wang C. Tumour Biol. 2013, in press. Tumour Biol. 2014, 35(4):3941-2.
Jonckheere N, Vasseur R, and Van Seuningen I. The cornerstone K-ras mutation in pancreatic adenocarcinoma: from cell signaling network, target genes, biological processes to therapeutic targeting. Critical Reviews Oncology and Hematology. 2017 Mar;111:7-19.
Jonckheere N, Skrypek N, and Van Seuningen I. Mucins and tumor resistance to chemotherapeutic drugs. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 2014 1846(1):142-151.
Jonckheere N, Skrypek N, Frénois F and Van Seuningen I. Membrane-bound mucin modular domains: from structure to function. Biochimie 2013 Jun;95(6):1077-86
Jonckheere N, Skrypek N and Van Seuningen I. Mucins and pancreatic cancer. Cancers 2010, 2, 1794-1812
Jonckheere N, Van Seuningen I. The membrane-bound mucins: From cell signalling to transcriptional regulation and expression in epithelial cancers. Biochimie. 2010 92(1):1-11.
Jonckheere N et Van Seuningen I. The membrane-bound mucins: How large O-glycoproteins play key roles in epithelial cancers and hold promise as biological tools for gene- and immuno-based therapies. Critical Reviews in Oncogenesis 2008; 14(2-3):177-96.
Van Seuningen I, Jonckheere N et Mariette C. Les mucines transmembranaires MUC1 et MUC4 : structure, fonction et rôle dans la carcinogenèse. Regard sur la Biochimie 2004;4:29-48
Jonckheere N et Van Seuningen I. Chapter VII “Promoter Reporters, Inducible Promoters, Synthetic Promoters”. The Analysis of Cis-elements: Current developments, knowledge and applications to gene networking. Bentham Science Publishers. Ed. K. Berendzen 2013, 149-161
Jonckheere N et Van Seuningen I. Chapter II “The ever growing family of membrane-bound mucins”. The epithelial mucins, structure/function. Roles in cancer and inflammatory diseases. Research Signpost, Kerala, India. Ed I. Van Seuningen, 2008, 17-38