Contact:
Cancer Heterogeneity, Plasticity and Resistance to Therapy - CANTHER
INSERM UMR-S1277 - CNRS UMR9020
Team "Mucins, epithelial differentiation and carcinogenesis "
Batiment Cancer, 1 rue Polonovski
59045, Lille cedex
France
Phone: (+33) 320298865
E-Mail: Nicolas.Jonckheere(at)inserm.fr
2004 PhD Life and Health Sciences
"Transcriptional regulation of human and murin mucins by TGF-b and transcription factors involved in gastrointestinal differentiation"
Ecole doctorale Biologie-Santé de Lille, France
2001 DEA (Master) Life and Health Sciences
Ecole doctorale Biologie-Santé de Lille, France
1995 Scientific Baccalauréat Earth and Life Sciences
Lycée d'état Raymond Queneau, Villeneuve d'Ascq, France
2014 AUEC Experimental surgery applied to physiopathology models. Medecine Faculty of Lille
2014 Habilitation à Diriger des Recherches (HDR) MUC4 mucin in pancreatic carcinogenesis : In vivo and chemoresistance roles, Université Droit et Santé – Lille 2.
2008 Animal experimentation training, « From genetic modification to functional and compartmental exploration », Level I, Lille, France (agreement N° 59-350204)
Since 2020: Chargé de Recherche Inserm - CANTHER - Team "Mucins, epithelial differentiation and carcinogenesis" (Dir : Dr Isabelle Van Seuningen).
Research interests: My research is focused on roles of membrane bound mucin in pancreatic carcinogenesis. We are investigating (i) the role of MUC4 in vivo using transgenic mouse model and (ii) the impact of MUC4 in chemoresistance.
2012- 2019 : 1st class Chargé de Recherche CR1 Inserm UMR-S1172 Team mucins, epithelial differentiation and carcinogenesis (Dir : Dr Isabelle Van Seuningen), Centre de Recherche Jean-Pierre AUBERT– JPARC, Lille, France., Dir : Luc Buée
2007-12: Postdoctoral researcher Inserm UMR837 Team 5 " mucins, epithelial differentiation and carcinogenesis ", Centre de Recherche Jean-Pierre AUBERT– JPARC, Lille, France., Dir : Pierre Formstecher
Research interests: Role of MUC4-ErbB2 complex in pancreatic carcinogenesis
2005-07: Postdoctoral researcher University of California Irvine, Department of Developmental and Cell Biology, Irvine, USA,. Dir. : Dr Maike Sander
Research interests: Determination of the role of mPygo2 in pancreatic development using a knock-out mouse model mPygo2-/-
2004: Postdoctoral researcher (collaboration): Erasmus Medical Center, Laboratory of Pediatrics, Department of Neonatology, Rotterdam, The netherlands. Dir : Dr Ingrid B Renes
2001-04: PhD, INSERM U560 « Epithelial mucins, from genes to functions », Dir : Dr Jean-Pierre Aubert. Groupe « Cell signaling and transcriptional regulation », PhD mentor : Dr Isabelle Van Seuningen. Lille, France.
Research interests: Regulation of human and murin mucine genes by TGF-b and transcription factors involved in gastro-intestinal differentiation
2010-12 Postdoctoral fellowship of Ligue national contre le Cancer (LNCC)
2008-09 Postdoctoral fellowship of Institut National du Cancer (INCa)
2007 Scientific Award of Club Français du Pancréas – Solvay Pharma
2002-04 PhD fellowship of Centre Hospitalier Régional et Universitaire de Lille – Région Nord Pas de Calais
Molecular biology (PCR, qRT-PCR, gel shift assays EMSA, site directed mutagenesis, chromatine immunoprecipitation)
Biochemistry (western blotting, Immunohistochemistry, Immunofluorescence)
Cell biology (transient and stable cell transfections, proliferation, migration, invasion, flow cytometry)
Animal models (characterization of transgenic mice, experimental surgery)
Transcriptional regulation and cell signaling (promoters regulation, miRNA)
Epithelial carcinogenesis
French scientific societies:
President of Club d’Etude des Cellules Epithéliales Digestives (CECED).
Founding member of Association Française de la Recherche sur le Cancer Pancréatique (AFRCP).
former Member of the Executive Committee Club Français du Pancréas (CFP)
webpage Club Français du Pancréas
Membership :
- Société Française de Biochimie et Biologie Moléculaire (SFBBM),
- Société de Biologie Cellulaire de France (SBCF),
International: Membership of European Pancreatic Club (EPC)
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