PUBLICACIONES

2025

• Health position paper and redox perspectives - Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases. Redox Biology. DOI: 10.1016/j.redox.2025.103569

• Model organisms for investigating the functional involvement of NRF2 in non-communicable diseases. Redox Biology. DOI: 10.1016/j.redox.2024.103464

• Unveiling the interplay between soluble guanylate cyclase activation and redox signalling in stroke pathophysiology and treatment. Biomedicine & Pharmacotherapy. DOI: 10.1016/j.biopha.2025.117829

• Targeting CB2 Receptor with a Novel Antagonist Reverses Cognitive Decline, neurodegeneration and Pyroptosis in a TAU-Dependent Frontotemporal Dementia MOUSE Model. Brain Behavior and Immunity. DOI: 10.1016/j.bbi.2025.03.008

2024

• The mitochondrial Na+/Ca2+ exchanger NCLX is implied in the activation of hypoxia-inducible factors. Redox Biol. DOI: 10.1016/j.redox.2024.103364

• Discovery of a potent melatonin-based inhibitor of quinone reductase-2 with neuroprotective and neurogenic properties. Eur J Med Chem. DOI: 10.1016/j.ejmech.2024.116763

• Innovative pathological network-based multitarget approaches for Alzheimer’s disease treatment. Med Res Rev. DOI: 10.1002/med.22045

• Reduction in Hippocampal Aβ Content During Gly-Pro-Glu Co-Administration Is Associated with Changes in Inflammation and IGF-I Signaling. International Journal of Molecular Sciences. DOI: 1422-0067/25/11/5716

2023

• Adipose tissue as a therapeutic target for vascular damage in Alzheimer’s disease. Br J Pharmacol. DOI: 10.1111/bph.16243

• Small synthetic hyaluronan disaccharide BIS014 mitigates neuropathic pain in mice. J Pain. DOI: 10.1016/j.jpain.2022.07.014

• Cytotoxicity models in chromaffin cells to evaluate neuroprotective compounds. Methods Mol Biol. DOI: 10.1007/978-1-0716-2671-9_24

2022

• Microglial Hemoxygenase-1 deletion reduces inflammation in the retina of old mice with tauopathy. Antioxidants. DOI: 10.3390/antiox11112151

• KEAP1-NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential. Medicinal Research Reviews. DOI: 10.1002/med.21925

• Implication of type 4 NADPH oxidase (NOX4) in tauopathy. Redox Biology. DOI: 10.1016/j.redox.2021.102210

• Resveratrol-based MTDLs to stimulate defensive and regenerative pathways and block early events in neurodegenerative cascades. J. Med. Chem. DOI: 10.1021/acs.jmedchem.1c01883

• Un-biased housekeeping gene panel selection for high-validity gene expression analysis. Sci Rep. DOI: 10.1038/s41598-022-15989-8

2021

• Central Activation of Alpha7 Nicotinic Signaling Attenuates LPS-Induced Neuroinflammation and Sickness Behavior in Adult but Not in Aged Animals. Molecules. DOI: 10.3390/molecules26082107

• Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice. Nature Communcations. DOI: 10.1038/s41467-021-22501-9

• Cannabinoid receptor CB2 ablation protects against TAU induced neurodegeneration. Acta Neuropathol Commun. DOI: 10.1186/s40478-021-01196-5

• Intracellular calcium and inflammatory markers, mediated by purinergic stimulation, are differentially regulated in monocytes of patients with major depressive disorder. Neuroscience Letters. DOI: 10.1016/j.neulet.2021.136275

• Protective role of microglial HO-1 blockade in aging: implication of iron metabolism. Redox Biology. DOI: 10.1016/j.redox.2020.101789

• Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4th edition). Autophagy. DOI: 10.1080/15548627.2015.1100356

2020

• Cognitive enhancement, tau phosphorylation reduction and neuronal protection by the treatment of a LRRK2 inhibitor in a taoupathy mouse model. Neurobiology of Aging. DOI: 10.1016/j.neurobiolaging.2020.09.006

• Melatonin-sulforaphane hybrid ITH12674 attenuates glial response in vivo by blocking LPS binding to MD2 and receptor oligomerization. Pharmacological Research. DOI: 10.1016/j.phrs.2019.104597

• Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties. Eur. J. Med. Chem. DOI: 10.1016/j.ejmech.2020.112090

• Aging and Progression of Beta-Amyloid Pathology in Alzheimer’s Disease Correlates with Microglial Heme-Oxygenase-1 Overexpression. Antioxidants. DOI: 10.3390/antiox9070644

• Na+ controls hypoxic signalling by the mitochondrial respiratory chain. Nature. DOI 10.1038/s41586-020-2551-y

• Antioxidant, anti-inflammatory and neuroprotective profiles of novel 1,4-dihydropyridine derivatives for the treatment of Alzheimer’s disease. Antioxidants. DOI: 0.3390/antiox9080650

• Protective role of microglial HO-1 blockade in aging: Implication of iron metabolism. Redox Biology. DOI: 10.1016/j.redox.2020.101789

• The molecular and pharmacological modulation of CALHM1 promotes neuroprotection against oxygen and glucose deprivation in a model of hippocampal slices.Cells. DOI: 10.3390/cells9030664

2019

• Pharmacological doses of melatonin impede cognitive decline in tau-related Alzheimer models, once tauopathy is initiated, by restoring the autophagic flux. Journal of Pineal research. DOI: 10.1111/jpi.12578

• Calcium-dependent reactive oxygen formation and blood-brain barrier breakdown by NOX5 limits post-reperfusion benefit in stroke. J Clin. Invest. DOI: 10.1172/JCI124283.

• From single drug targets to synergistic network pharmacology in ischemic stroke. Proc Natl Acad Sci U S A. DOI: 10.1073/pnas.1820799116 

• Neuroprotective effects of EpoL against oxidative stress induced by soluble oligomers of Aß peptide. Redox Biol. DOI: 10.1016/j.redox.2019.101187

• Improvement in inflammation is associated with the protective effect of Gly-Pro-Glu and cycloprolylglycine against Aβ-induced depletion of the hippocampal somatostatinergic system. Neuropharmacology. DOI: 10.1016/j.neuropharm.2019.04.008.

• Neuroprotective activity of isoquinoline alkaloids from of Chilean Amaryllidaceae plants against oxidative stress-induced cytotoxicity on human neuroblastoma SH-SY5Y cells and mouse hippocampal slice culture. Food and Chemical  Toxicology. DOI: 10.1016/j.fct.2019.110665 

• 1-(2’,5’-Dihydroxyphenyl)-3-(2-fluoro-4-hydroxyphenyl)-1-propanone (RGM079): A positive allosteric modulator of α7 nicotinic receptors with analgesic and neuroprotective activity. ACS Chemical Neuroscience. DOI: 10.1021/acschemneuro.9b00364 

2018

• Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach. Pharmacol Rev. DOI: 10.1124/pr.117.014753

• Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy. Redox Biol. DOI: 10.1016/j.redox.2018.07.006

• Chromaffin cells as a model to evaluate mechanisms of cell death and neuroprotective compounds. Pflügers Archiv - European Journal of Physiology. DOI: 10.1007/s00424-017-2044-5 

• A diseasome cluster-based drug repurposing of soluble guanylate cyclase activators from smooth muscle relaxation to direct neuroprotection. NPJ Systems Biology and Applications. DOI: 10.1038/s41540-017-0039-7

• The APPswe/PS1A246E mutations in an astrocytic cell line leads to increased vulnerability to oxygen and glucose deprivation, Ca2+ dysregulation and mitochondrial abnormalities. J. Neurochem. DOI: 10.1111/jnc.14293