NEUROBIOSYS

NEUROBIOSYS

NEUROBIOSYS is a research group recognised by the Diputación General de Aragón (DGA) that carries out its research at the Institute of Biocomputation and Physics of Complex Systems (BIFI) of the University of Zaragoza. Our goal is to understand the molecular basis of the mechanism of action of neuronal biological complexes related to the basic functioning of the nervous system and neuropathologies.

The human brain is the least known organ and its dysfunction generates neurological diseases that affect millions of people worldwide. Pathologies such as epilepsy, schizophrenia or depression, as well as neurodegenerative diseases diminish the quality of life of patients and their families.  The lack of basic knowledge means that most neurological disorders do not have adequate treatments. For this reason, the research groups belonging to NEUROBIOSYS study fundamental processes in brain function as well as the mechanisms that generate neuropathologies. Some examples are the mechanisms of amyloid aggregates in neurodegeneration, the functioning of receptors involved in neuronal communication and the mode of action of drugs used for the treatment of neuropathologies. Examples include the mechanisms of amyloid aggregates in neurodegeneration, the functioning of receptors involved in neuronal communication and the mode of action of drugs used for the treatment of neuropathologies. This is achieved by combining technologies encompassing single particle biophysical studies, molecular and cell biology, biophysics of molecular interactions, biochemical assays and high-resolution electron cryo-microscopy.