that will help advance patient-oriented research.7 Canadians Seeking Solutions and Innovations to Overcome Chronic Kidney Disease (Can-SOLVE CKD) is one of 5 pan-Canadian chronic disease networks supported through SPOR. The vision of Can-SOLVE CKD is that by 2020, every Canadian with or at high risk for CKD will receive the best recommended care, experience optimal outcomes, and have the opportunity to participate in studies with novel therapies, regardless of age, sex, gender, location, or ethnicity. The network is led by a steering committee that includes a broad range of patients affected by a representative mix of medical conditions, policy makers, researchers, and charitable foundations. Its co-principal investigators are Dr Adeera Levin (University of British Columbia) and Dr Braden Manns (University of Calgary). This article serves to describe the Can-SOLVE CKD Network, a program of research projects and infrastructure that has excited patients and given them hope that we can truly transform the care they receive. Network Objective The overarching objective of Can-SOLVE CKD is to accelerate the translation of knowledge about CKD into clinical research and practice. To fulfill this objective, a coast-tocoast partnership of patients, health care providers, policyand decision-makers (herein referred to as policy makers), and researchers will build on key existing human resources, core infrastructure, and research partnerships to create a sustainable network. Network Development The Can-SOLVE CKD Network builds on an existing collaborative community that has emerged in Canada over the last 15 years and is committed to improving the quality of care and outcomes for CKD patients. Two planning conferences, in 2000 and 2007,8,9 involved key stakeholders from the kidney community. The first led to the development of a national interdisciplinary training program (Kidney Research Scientist Core Education and National Training [KRESCENT], www.krescent.ca)10 for allied health professionals, basic scientists, and clinician scientists. The second conference led to the formation in 2010 of the CAnadian 4 Canadian Journal of Kidney Health and Disease KidNey KNowledge TraNslation and Generation NeTwork (www.CANN-NET.ca)11 to enhance collaboration and exchange of information between researchers and knowledge users. The Can-SOLVE CKD Network, with its broad engagement of key stakeholders, is well positioned to consolidate and leverage these activities to overcome the limitations of existing networks and address the needs of all people with CKD, extending the benefits to Canadians with other chronic diseases. Patient-Oriented Research Program The goal of patient-oriented research is “to better ensure the translation of innovative diagnostic and therapeutic approaches to the point of care, as well as to help the provinces and territories meet the challenge of delivering high quality, cost-effective health care.”12 Patient-oriented research focuses on priorities that are important to patients, engages patients in the research process, and produces information that can be used in meaningful ways to improve health care practice. Using an established patient priority-setting framework by the James Lind Alliance,13 a 3-year national process of patient consultation was undertaken to identify the top 10 research priorities of individuals with early or more advanced CKD, their families, and care providers (Figure 1).9,14,15 Since the inception of the Can-SOLVE CKD Network in March 2014, patients have continued to meet regularly with researchers and policy makers. Two workshops were held with more than 30 patients, caregivers, Indigenous peoples, researchers, and policy makers to finalize research priorities using a modified Delphi process. These priorities informed the development of 18 multidisciplinary research projects spanning biomedical first-in-human studies, clinical research trials, population health research, and knowledge translation (KT). This research agenda forms the foundation of the network. Figure 1. Can-SOLVE CKD patient-oriented priority-setting process. Note. Can-SOLVE CKD = Canadians Seeking Solutions and Innovations to Overcome Chronic Kidney Disease; KFOC = Kidney Foundation of Canada; CKD = chronic kidney disease. Levin et al 5 The highest priority areas identified by patients and policy makers were those pertaining to early diagnosis and prognosis—improved understanding of pathobiology and stratifying patients based on risk (Theme 1); treatment options for CKD and comorbidities, and how best to address physical and emotional symptoms (Theme 2); and optimal models of care in chronic disease (Theme 3). Table 1 illustrates research priorities and projects that patients and policy makers included within each theme, connected by a common focus on stratification and personalization. Two examples of the research projects conducted under Can-SOLVE CKD are described in Table 2. Others are available at www.cansolveckd.ca. As the network executes the projects, patients have been integrated into the research teams, bringing the patient voice to all aspects of the research: design, development, recruitment, implementation, and KT. This partnership is a new way of doing research, requiring a culture change for all involved. To help effect this change,