S P Choukem; S A Dada; M R Davids; M H Ekat; R T Erasmus; J Fabian; J A George; Z Gouda; H Grosskurth; R Kalyesubula; S Kapiga; F F Kaze; R Kruger; L Lammertyn; T E Matsha; C M C Mels; O C A Okoye; R Oluyombo; C Osafo; R N Peck; N Peer; R O Phillips; Y R Raji; M Ramsay; B Rayner; A A Salawu; A E Schutte; I Ssinabulya; J W Stanifer; R Wanyama. Contributors CG, SS, IO, MW and APK, who formed the core Writing Committee, contributed to the preparation of the manuscript. All collaborators were sent the manuscript as prepared for submission and given the opportunity to comment on the draft manuscript. The Writing Committee accepts full responsibility for the content of this manuscript. Funding This work was supported by the National Research Foundation (NRF) with funds from the Thuthuka Funding instrument (grant number TTK170504229669) to (CG). Several sources have supported the studies contributing to the CKD-Africa Collaboration and are described in the relevant publications. 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Ethics approval Ethical clearance was obtained from the SAMRCs Human Research Ethics Committee for the establishment of the consortium (reference: EC016-8/2017) and further ethical clearance are sought for individual projects pertaining to the consortium. Provenance and peer review Not commissioned; externally peer reviewed. Data availability statement The datasets depicted in this manuscript are available from the corresponding author of each primary study on reasonble request. Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise. Open access This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. ORCID iDs Cindy George http://orcid.org/0000-0002-4561-0529 Ikechi Okpechi http://orcid.org/0000-0002-6545-9715 REFERENCES 1 GBD Chronic Kidney Disease Collaboration. Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the global burden of disease study 2017. Lancet 2020;395:709–33. 2 Ene-Iordache B, Perico N, Bikbov B, et al. Chronic kidney disease and cardiovascular risk in six regions of the world (ISN-KDDC): a cross-sectional study. Lancet Glob Health 2016;4:e307–19. 3 Kaze AD, Ilori T, Jaar BG, et al. Burden of chronic kidney disease on the African continent: a systematic review and meta-analysis. BMC Nephrol 2018;19:125. 4 Abd ElHafeez S, Bolignano D, D'Arrigo G, et al. Prevalence and burden of chronic kidney disease among the general population and high-risk groups in Africa: a systematic review. BMJ Open 2018;8:e015069. 5 Vos T, Lim SS, Abbafati C, et al. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the global burden of disease study 2019. The Lancet 2020;396:1204–22. 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