4.50 from Paddington is a detective fiction novel by Agatha Christie, first published in November 1957 in the United Kingdom by Collins Crime Club. This work was published in the United States at the same time as What Mrs. McGillicuddy Saw!, by Dodd, Mead.[1] The novel was published in serial form before the book was released in each nation, and under different titles. The US edition retailed at $2.95.[1]

The UK title 4.50 from Paddington, specifies a train time departing in the afternoon from Paddington station, a major station in central London. In British style, the time is written as 4.50 (in later timetables it would be 16:50). The London railway stations were perhaps not considered well known by the US publisher, and thus the title in the US was changed to What Mrs McGillicuddy Saw!, which also refers to the moment on the train when the murder was seen.


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Fellow crime writer Anthony Berkeley Cox, writing under the pen name of Francis Iles, reviewed the novel in the 6 December 1957 issue of The Guardian, in which he confessed to being disappointed with the work: "I have only pity for those poor souls who cannot enjoy the sprightly stories of Agatha Christie; but though sprightliness is not the least of this remarkable writer's qualities, there is another that we look for in her, and that is detection: genuine, steady, logical detection, taking us step by step nearer to the heart of the mystery. Unfortunately it is that quality that is missing in 4.50 from Paddington. The police never seem to find out a single thing, and even Miss Marples (sic) lies low and says nuffin' to the point until the final dramatic exposure. There is the usual small gallery of interesting and perfectly credible characters and nothing could be easier to read. But please, Mrs Christie, a little more of that incomparable detection next time."[4]

The novel was published in the US under the title What Mrs. McGillicuddy Saw! by Dodd, Mead and Co. The UK version was to be titled 4.54 from Paddington until the last minute, when the title and text references were changed to 4.50 from Paddington. This change was not communicated to Dodd Mead until after the book was being printed, so the text references to the time show 4:54 rather than 4:50.[8]

Le crime est notre affaire is a French film directed by Pascal Thomas, released in 2008. Named after the book Partners in Crime, and, like the book, starring Tommy and Tuppence as the detective characters, the film is in fact an adaptation of 4.50 from Paddington. The locations and names differ, but the story is essentially the same. The film is a sequel to Mon petit doigt m'a dit..., a 2004 film by Pascal Thomas adapted from By the Pricking of My Thumbs. Both are set in Savoy in the present day.[citation needed]

On 17 June 2010, I-play released a downloadable hidden object game based on 4.50 from Paddington (see the external links). Dialogue interspersed with the hidden object puzzles follows the plot of the original story. Items mentioned in the dialogue are among those hidden in each round. The player finds locations on the map by textual clues, which makes the map a hidden object scene, too. At three points during play the player is asked to hypothesise on the identity of the murderer, but as in the novel there is little in the way of relevant evidence. Unlike the games based on Evil Under the Sun, Murder on the Orient Express, and And Then There Were None, this does not include any actual detection and unlike the latter two does not add an additional character to represent the player. This is the 4th in a series of Oberon Games' hidden object games based on Agatha Christie's novels, the first three were based on Death on the Nile, Peril at End House, and Dead Man's Folly.

4.50 from PaddingtonDetailsDirected by:Andy WilsonWritten by:Stephen ChurchettAdapted from:4.50 from PaddingtonSeries:Agatha Christie's MarpleSeason:Series 1Episode No.:3Starring:Geraldine McEwanNetwork:ITVRelease Date:26 December 2004Country of Origin:United KingdomIMDb: tt0443579Preceded by:The Murder at the VicarageFollowed by:A Murder is Announced4.50 from Paddington (US: 'What Mrs McGillicuddy Saw!') is the third episode of the first series of Agatha Christie's Marple. It was broadcast on ITV by Granada Television on 26 December 2004. The screenplay was written by Stephen Churchett, and the episode was directed by Andy Wilson. It an adaptation of the Agatha Christie novel of the same name.

Background:  More than 50% of patients with major depressive episode (MDE) fail to respond to initial treatment with first line pharmacological therapy. Altered receptor and serotonin transporter function are considered to be associated with mental disorders. Our investigation aimed on the density of the HT1A receptor in mesiotemporal cortex (MTC) and raphe measured by F18-Mefway in patients with MDD.

Methods:  Patients with untreated clinically suspected major depressive episode were recruited from June 2012 to May 2014. 49 patients were included into the study: 36 patients (73%) were identified as responders, whereas 13 (27%) were non-responders. Gender distribution was 26 men (56%) and 23 women (44%). For treatment, only a standard medication of a selective serotonin reuptake inhibitor (SSRI) with escitalopram in a range of 10-20 mg/day was permitted. Responders were defined by improvement of the MADRS>50%. Visually MTC had the highest uptake of F18-Mefway among all brain regions, an asymmetry could not be observed in any patient. An elliptical region was drawn over the amygdala and hippocampus area and a small circular region was drawn over the raphe nuclei. All data were calculated related to (unspecific) cerebellar uptake.

Results:  The quotient of the right MTC was 5.00 [4.33; 5.50] in all patients, in responders 5.00 [4.00; 5.75] and in non-responders 5.00 [4.50; 5.50] (P=0.56). The quotient of the left MTC presented with a median level of 4.50 [4.50; 5.50] in all persons. The responders had 4.50 [4.50; 5.75] which was not statistically significant to the data of the non-responders with 5.00 [4.50; 5.50] at P=0.64. The raphe had a median quotient of 2.50 [2.00; 3.00] in all and the cohort of responders, whereas non-responders had 2.50 [2.00; 2.50] (P=0.61). Also the absolute values of SUV in the three brain regions were not statistically different between the cohorts. Additionally, we did not find any sex-related differences in our patient group.

Absolutely loved the episode overall. The period after the fall of the Western Roman Empire has always been a favorite of mine and Dan handles it in a very interesting way. The biker gang comparison seemed a little much at times but, hey, sometimes if the shoe fits.

Modeled after Miss Marple in the original 1957 novel by Agatha Christie, Amano Touko used to be a capable police detective but now is a crisis management professional. She will work on a murder case on a moving train.(Source: MyDramaList)~~ Adapted from the novel "4.50 from Paddington" by Agatha Christie. Edit Translation

Polar SpecialSeasonEpisodeNoneSpecialAir date25th July, 2007Viewers4.50 millionStar(s)NoneEpisode guidePreviousNextSeries 9, Episode 6Series 10, Episode 1The Polar Special was a special episode of the BBC motoring show Top Gear, featuring the regular presenters Jeremy Clarkson, James May, and Richard Hammond. It is the show's third full-length special and was broadcast in July 2007, several months after the end of the ninth series. It was developed and released in order to lessen the drought of Top Gear during 2007 in the wake of Hammond's crash from September the year prior.

Making her Utah debut was Aoife Hickey finishing in the fourth spot with a throw of 54-06 feet. Destanae Howerton-Davis (48-11.00 feet) and freshman Sosina Salima (45-4.50 feet) finished seventh and ninth, respectively for the Utes. Competing unattached was Nikkie Rudder finishing fifth with a mark of 52-5.50 feet.

Martina Schneider is a psychologist and a teacher of Vipassana meditation. Her work with clients combines a therapeutic and a spiritual approach. In this episode, she talks with Andrew about her own spiritual journey, including intensive study of the Vedanta tradition in India and being ordained as a nun. Martina offers her thoughts on the time and the deep commitment it requires truly to understand the self and to be at peace with it.


For Emma George, it was just another high-flying routine. First, at the Australian national indoor competition in Adelaide on 26 March 1998, the former childhood trapeze artist soared over 4.50m. In doing so, she became the first female pole vaulter to achieve the feat indoors, 11 months after she had been the first to clear the mark outdoors. be457b7860

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