Selected Publications
Embedded Files
T. Yamamuro, D. Katoh, G. M. Silva, H. Nishida, S. Oikawa, Y. Higuchi, D. Wang, M. Fujimoto, N. Yoshida, M. Li, J. Shin, Z. Zhao, J.-S. Yook, L. Sun, S. Kajimura, Mitochondrial control of glycerolipid synthesis by a PEP shuttle, Cell 189(10), 2988-3003.e23. (2026). https://doi.org/10.1016/j.cell.2026.02.017
T. Yamamuro, S. Nakamura, K. Yanagawa, A. Tokumura, T. Kawabata, A. Fukuhara, H. Teranishi, M. Hamasaki, I. Shimomura, T. Yoshimori, Loss of RUBCN/rubicon in adipocytes mediates the upregulation of autophagy to promote the fasting response. Autophagy 18(11), 2686-2696. (2022).
https://doi.org/10.1080/15548627.2022.2047341
T. Yamamuro, S. Nakamura, Y. Yamano, T. Endo, K. Yanagawa, A. Tokumura, T. Matsumura, K. Kobayashi, H. Mori, Y. Enokidani, G. Yoshida, H. Imoto, T. Kawabata, M. Hamasaki, A. Kuma, S. Kuribayashi, K. Takezawa, Y. Okada, M. Ozawa, S. Fukuhara, T. Shinohara, M. Ikawa, T. Yoshimori, Rubicon prevents autophagic degradation of GATA4 to promote Sertoli cell function. PLoS Genet. 17(8), e1009688. (2021).
https://doi.org/10.1371/journal.pgen.1009688
T. Yamamuro, T. Kawabata, A. Fukuhara, S. Saita, S. Nakamura, H. Takeshita, M. Fujiwara, Y. Enokidani, G. Yoshida, K. Tabata, M. Hamasaki, A. Kuma, K. Yamamoto, I. Shimomura, T. Yoshimori, Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy. Nat. Commun. 11(1), 4150 (2020).
All Publications
T. Yamamuro, D. Katoh, G. M. Silva, H. Nishida, S. Oikawa, Y. Higuchi, D. Wang, M. Fujimoto, N. Yoshida, M. Li, J. Shin, Z. Zhao, J.-S. Yook, L. Sun, S. Kajimura, Mitochondrial control of glycerolipid synthesis by a PEP shuttle, Cell 189(10), 2988-3003.e23. (2026). https://doi.org/10.1016/j.cell.2026.02.017
S. Oikawa, T. Yamamuro, H. Nishida, D. Katoh, D. Wang, M. Fujimoto, S. Kajimura, Mitochondrial control of amino acid catabolism by a fasting-inducible mitochondrial carrier, Science Advances 12(31), eaef0140. (2026).
https://doi.org/10.1126/sciadv.aef0140
D. Katoh, Y. Senga, K. Mizutani, K. Maruyama, D. Yamakawa, T. Yamamuro, M. Hiroe, K. Yamanaka, A. Sudo, N. Katayama, T. Yoshida, K. Imanaka-Yoshida, Negative regulation of lymphangiogenesis by Tenascin-C delays the resolution of inflammation, iScience 28(2), 111756. (2025).
https://doi.org/10.1016/j.isci.2025.111756
J. Nakamura, T. Yamamoto, Y. Takabatake, T. Namba-Hamano, A. Takahashi, J. Matsuda, S. Minami, S. Sakai, H. Yonishi, S. Maeda, S. Matsui, H. Kawai, I. Matsui, T. Yamamuro, R. Edahiro, S. Takashima, A. Takasawa, Y. Okada, T. Yoshimori, A. Ballabio, Y. Isaka, Age-related TFEB downregulation in proximal tubules causes systemic metabolic disorders and occasional apolipoprotein A4-related amyloidosis. JCI Insight 10(3), e184451. (2024).
https://doi.org/10.1172/jci.insight.184451
K. Yanagawa, A. Kuma, M. Hamasaki, S. Kita, T. Yamamuro, K. Nishino, S. Nakamura, H. Omori, T. Kaminishi, S. Oikawa, Y. Kato, R. Edahiro, R. Kawagoe, T. Taniguchi, Y. Tanaka, T. Shima, K. Tabata, M. Iwatani, N. Bekku, R. Hanayama, Y. Okada, T. Akimoto, H. Kosako, A. Takahashi, I. Shimomura, Y. Sakata, T. Yoshimori, The Rubicon–WIPI axis regulates exosome biogenesis during ageing. Nat. Cell Biol. 26(9), 1558–1570. (2024).
https://doi.org/10.1038/s41556-024-01481-0
A. R. P. Verkerke, X. Shi, M. Li, Y. Higuchi, T. Yamamuro, D. Katoh, H. Nishida, C. Auger, I. Abe, R. E. Gerszten, S. Kajimura, SLC25A48 controls mitochondrial choline import and metabolism. Cell Metab. 36(9), 2156-2166.e9. (2024).
https://doi.org/10.1016/j.cmet.2024.07.010
Y. Ukon, T. Kaito, H. Hirai, T. Kitahara, M. Bun, J. Kodama, D. Tateiwa, S. Nakagawa, M. Ikuta, T. Furuichi, Y. Kanie, T. Fujimori, S. Takenaka, T. Yamamuro, S. Otsuru, S. Okada, M. Yamashita, T. Imamura, Cellular senescence by loss of Men1 in osteoblasts is critical for age-related osteoporosis. Aging Cell 23(10), e14254. (2024).
https://doi.org/10.1111/acel.14254
Q. Wang, H. Li, K. Tajima, A. R. P. Verkerke, Z. H. Taxin, Z. Hou, J. B. Cole, F. Li, J. Wong, I. Abe, R. N. Pradhan, T. Yamamuro, T. Yoneshiro, J. N. Hirschhorn, S. Kajimura, Post-translational control of beige fat biogenesis by PRDM16 stabilization. Nature 609(7925), 151–158. (2022).
https://doi.org/10.1038/s41586-022-05067-4
T. Yamamuro, S. Nakamura, K. Yanagawa, A. Tokumura, T. Kawabata, A. Fukuhara, H. Teranishi, M. Hamasaki, I. Shimomura, T. Yoshimori, Loss of RUBCN/rubicon in adipocytes mediates the upregulation of autophagy to promote the fasting response. Autophagy 18(11), 2686-2696. (2022).
https://doi.org/10.1080/15548627.2022.2047341
H. Yamamoto-Imoto, S. Minami, T. Shioda, Y. Yamashita, S. Sakai, S. Maeda, T. Yamamoto, S. Oki, M. Takashima, T. Yamamuro, K. Yanagawa, R. Edahiro, M. Iwatani, M. So, A. Tokumura, T. Abe, R. Imamura, N. Nonomura, Y. Okada, D. E. Ayer, H. Ogawa, E. Hara, Y. Takabatake, Y. Isaka, S. Nakamura, T. Yoshimori, Age-associated decline of MondoA drives cellular senescence through impaired autophagy and mitochondrial homeostasis. Cell Reports 38(9), 110444. (2022).
https://doi.org/10.1016/j.celrep.2022.110444
G. Yoshida, T. Kawabata, H. Takamatsu, S. Saita, S. Nakamura, K. Nishikawa, M. Fujiwara, Y. Enokidani, T. Yamamuro, K. Tabata, M. Hamasaki, M. Ishii, A. Kumanogoh, T. Yoshimori, Degradation of the NOTCH intracellular domain by elevated autophagy in osteoblasts promotes osteoblast differentiation and alleviates osteoporosis. Autophagy 18(10), 2323-2332. (2022).
https://doi.org/10.1080/15548627.2021.2017587
T. Yamamuro, S. Nakamura, Y. Yamano, T. Endo, K. Yanagawa, A. Tokumura, T. Matsumura, K. Kobayashi, H. Mori, Y. Enokidani, G. Yoshida, H. Imoto, T. Kawabata, M. Hamasaki, A. Kuma, S. Kuribayashi, K. Takezawa, Y. Okada, M. Ozawa, S. Fukuhara, T. Shinohara, M. Ikawa, T. Yoshimori, Rubicon prevents autophagic degradation of GATA4 to promote Sertoli cell function. PLoS Genet. 17(8), e1009688. (2021).
https://doi.org/10.1371/journal.pgen.1009688
T. Yamamuro, T. Kawabata, A. Fukuhara, S. Saita, S. Nakamura, H. Takeshita, M. Fujiwara, Y. Enokidani, G. Yoshida, K. Tabata, M. Hamasaki, A. Kuma, K. Yamamoto, I. Shimomura, T. Yoshimori, Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy. Nat. Commun. 11(1), 4150 (2020).
https://doi.org/10.1038/s41467-020-17985-w
T. Yamamuro, A. Fukuhara, J. Kang, J. Takamatsu, A case of necrotizing fasciitis following Edwardsiella tarda septicemia with gastroenteritis. J. Infect. Chemother. 25(12), 1053–1056 (2019).
https://doi.org/10.1016/j.jiac.2019.05.017
S. Nakamura, M. Oba, M. Suzuki, A. Takahashi, T. Yamamuro, M. Fujiwara, K. Ikenaka, S. Minami, N. Tabata, K. Yamamoto, S. Kubo, A. Tokumura, K. Akamatsu, Y. Miyazaki, T. Ka-wabata, M. Hamasaki, K. Fukui, K. Sango, Y. Watanabe, Y. Takabatake, T. S. Kitajima, Y. Okada, H. Mochizuki, Y. Isaka, A. Antebi, T. Yoshimori, Suppression of autophagic activity by Rubicon is a signature of aging. Nat. Commun. 10(1), 847 (2019).
https://doi.org/10.1038/s41467-019-08729-6
T. Yamamuro, K. Inoue, Y. Nagai, D. Azuma, A. Yamamoto, K. Hara, M. Kohara, T. Iwata, S. Nakatsuka, E. Morii, T. Yamamoto, A case of ectopic ACTH syndrome due to DDAVP-sensitive but V1b receptor-negative bronchial typical carcinoid with lymphatic metastasis and plasma ProGRP elevation. Endocr. J. 65(12), EJ18-0052 (2018).
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