2026年
Yamanashi Y, Kitani M, Kumamaru M, Fukaya T, Sugita R, Takada T
Dual functions of NPC1L1 for cholesterol transport: Cholesterol capture and regulation of inner-leaflet cholesterol accessibility.
iScience, 29, 117625, 2026
Yamamoto S, Inoue K, Yasujima T, Takei H, Yamashiro T, Asai K, Matake I, Uchiyama S, Ohta K, Kishimoto H, Higuchi K, Anayama H, Asao Y, Hirabayashi H, Amano N, Shimizu T, Takada T, Tamura T, Wakai K, Kawamura Y, Nakayama A, Toyoda Y, Matsuo H, Yuasa H
SLC52A1 Is a Neofunctionalized Primate Urate Transporter Enabling Intestinal Urate Secretion.
J. Biol. Chem.,111310, 2026.
Mimura Y, Sanda T, Unno R, Furukawa Y, Shizu R, Motokatsu K, Tashiro Y, Tasaki Y, Sugiyama Y, Yasujima T, Naiki T, Horita Y, Hotta Y, Yuasa H, Yoshinari K, Yasui T, Iida S, Furukawa-Hibi Y
Sustained Drug-Drug Interaction Between Cyclosporine and Apalutamide in a Patient With Metastatic Hormone-Sensitive Prostate Cancer: A Case Report and Evaluation of CYP3A4 Induction via Pregnane X Receptor Activation by Apalutamide.
Case Rep. Oncol. Med., 3539500, 2026.
Matake I, Yasujima T, Matsuo H, Nakayama A, Toyoda Y, Takada T, Inoue K, Yamashiro T, Yuasa H
ENT3: A lysosomal urate transporter regulating urate disposition and macrophage inflammation.
iScience, 28, 114249, 2025
Sakoda R, Saito T, Hirasawa A, Ishiuchi K, Yasujima T, Yuasa H, Makino T
Stereoisomerism at the 3-position of glycyrrhetinic acid affects pseudoaldosteronism-related toxicokinetics.
Drug Metab. Dispos., 53, 100180, 2025.
Yasujima T, Namba C, Azuma Y, Shinoda Y, Matake I, Yamasaki M, Morimoto H, Namai M, Kusuhara H, Inoue K, Yamashiro T, Yuasa H
The role of FLVCR1 and FLVCR2 in choline transport in the Caco-2 intestinal epithelial cell model and rat small intestine.
Biochim. Biophys. Acta. Mol. Basis. Dis., 1871, 167883, 2025.
Iida M , Tasaki Y, Kato A, Yasujima T, Yuasa H, Maeda Y, Mimura Y, Odagiri K, Kimura Y, Ito N, Horita Y, Sugiyama Y, Hotta Y, Toyama T, Furukawa-Hibi Y
Refractory diarrhea in a patient with metastatic breast cancer with ABCB1 polymorphism: A case report.
Curr. Probl. Cancer Case Rep., 18, 100367, 2025.
Matake I, Yasujima T, Matsuo H, Toyoda Y, Kawamura Y, Takada T, Inoue K, Yamashiro T, Yuasa H
Functional characteristics of equilibrative nucleoside transporter 2 (ENT2/SLC29A2) for the transport of urate as a newly identified substrate.
Drug Metab. Pharmacokinet., 62, 101048, 2025
Mimura Y, Yasujima T, Inoue K, Akino S, Namba C, Kusuhara H, Sekiguchi Y, Ohta K, Yamashiro T, Yuasa H
SLC35G1 is a highly chloride-sensitive transporter responsible for the basolateral membrane transport in intestinal citrate absorption.
eLife, 13, RP98853, 2024.
Hosooka A, Yasujima T, Murata A, Yamashiro T, Yuasa H
Identification of human-specific amino acid residues governing atenolol transport via organic cation transporter 2.
Biochem. Pharmacol., 229, 116514, 2024.
Akino S, Yasujima T, Shibutani R, Yamashiro T, Yuasa H
Involvement of Proton-Coupled SLC49A4-Mediated Transport in the Export of Lysosomally Trapped Pyrilamine.
Drug Metab. Dispos., 52, 19-25, 2023.
Akino S, Yasujima T, Yamashiro T, Yuasa H
Disrupted in renal carcinoma 2 (DIRC2/SLC49A4) is an H+-driven lysosomal pyridoxine exporter.
Life Sci. Alliance, 6, e202201629, 2023.
Miyake K, Yasujima T, Takahashi S, Yamashiro T, Yuasa H
Identification of the amino acid residues involved in the species-dependent differences in the pyridoxine transport function of SLC19A3.
J. Biol. Chem., 298, 102161, 2022.
Yamashiro T, Yasujima T, Yuasa H
Animal species differences in the pyridoxine transport function of SLC19A3: Absence of Slc19a3-mediated pyridoxine uptake in the rat small intestine.
Drug Metab. Pharmacokinet., 44, 100456, 2022.
Shinoda Y, Yamashiro T, Hosooka A, Yasujima T, Yuasa H
Functional characterization of human organic anion transporter 10 (OAT10/SLC22A13) as an orotate transporter.
Drug Metab. Pharmacokinet., 43, 100443, 2022.
Anandam KY, Srinivasan P, Yasujima T, Al-Juburi S, Said HM
Proinflammatory cytokines inhibit thiamin uptake by human and mouse pancreatic acinar cells: involvement of transcriptional mechanism(s).
Am. J. Physiol. Gastrointest. Liver Physiol., 320, G108-G116, 2021.
Ramamoorthy K, Anandam KY, Yasujima T, Srinivasan P, Said HM
Posttranscriptional regulation of thiamin transporter-1 expression by microRNA-200a-3p in pancreatic acinar cells.
Am. J. Physiol. Gastrointest. Liver Physiol., 319, G323-G332, 2020.
Yamashiro T, Yasujima T, Said HM, Yuasa H
pH-dependent pyridoxine transport by SLC19A2 and SLC19A3: Implications for absorption in acidic microclimates.
J. Biol. Chem., 295, 16998-17008, 2020.
Kabeya T, Mima S, Imakura Y, Miyashita T, Ogura I, Yamada T, Yasujima T, Yuasa H, Iwao T, Matsunaga T
Pharmacokinetic functions of human induced pluripotent stem cell-derived small intestinal epithelial cells.
Drug Metab. Pharmacokinet., 35, 374-382, 2020.
Takenaka R, Yasujima T,* Furukawa J, Hishikawa Y, Yamashiro T, Ohta K, Inoue K, Yuasa H
Functional Analysis of the Role of Equilibrative Nucleobase Transporter 1 (ENBT1/SLC43A3) in Adenine Transport in HepG2 Cells.
J. Pharm. Sci., 109, 2622-2628, 2020.
Yamashiro T, Yasujima T, Ohta K, Inoue K, Yuasa H
Identification of the amino acid residue responsible for the myricetin sensitivity of human proton-coupled folate transporter.
Sci. Rep., 9, 18105, 2019.
Ishiuchi K, Morinaga O, Ohkita T, Tian C, Hirasawa A, Mitamura M, Maki Y, Kondo T, Yasujima T, Yuasa H, Minamizawa K, Namiki T, Makino T
18β-glycyrrhetyl-3-O-sulfate would be a causative agent of licorice induced pseudoaldosteronism.
Sci. Rep., 9, 1587, 2019.
Morinaga O, Ishiuchi K, Ohkita T, Tian C, Hirasawa A, Mitamura M, Maki Y, Yasujima T, Yuasa H, Makino T
Isolation of a novel glycyrrhizin metabolite as a causal candidate compound for pseudoaldosteronism.
Sci. Rep., 8, 15568, 2018.
Yasujima T, Murata C, Mimura Y, Murata T, Ohkubo M, Ohta K, Inoue K, Yuasa H
Urate transport function of rat sodium-dependent nucleobase transporter 1.
Physiol. Rep., 6, e13714, 2018.
Furuya T, Takehara I, Shimura A, Kishimoto H, Yasujima T, Ohta K, Shirasaka Y, Yuasa H, Inoue K
Organic anion transporter 1 (OAT1/SLC22A6) enhances bioluminescence based on d-luciferin-luciferase reaction in living cells by facilitating the intracellular accumulation of d-luciferin.
Biochem. Biophys. Res. Commun., 495, 2152-2157, 2018.
Yamashiro T, Yasujima T, Ohta K, Inoue K, Yuasa H
Specific inhibitory effects of myricetin on human proton-coupled folate transporter: Comparison with its effects on rat proton-coupled folate transporter and human riboflavin transporter 3.
Drug Metab. Pharmacokinet., 32, 311-314, 2017.
Mimura Y, Yasujima T,* Ohta K, Inoue K, Yuasa H
Functional identification of plasma membrane monoamine transporter (PMAT/SLC29A4) as an atenolol transporter sensitive to flavonoids contained in apple juice.
J. Pharm. Sci., 106, 2592-2598, 2017.
Nakayama A, Nakaoka H, Yamamoto K, Sakiyama M, Shaukat A, Toyoda Y, Okada Y, Kamatani Y, Nakamura T, Takada T, Inoue K, Yasujima T, Yuasa H, Shirahama Y, Nakashima H, Shimizu S, Higashino T, Kawamura Y, Ogata H, Kawaguchi M, Ohkawa Y, Danjoh I, Tokumasu A, Ooyama K, Ito T, Kondo T, Wakai K, Stiburkova B, Pavelka K, Stamp LK, Dalbeth N; Eurogout Consortium; Sakurai Y, Suzuki H, Hosoyamada M, Fujimori S, Yokoo T, Hosoya T, Inoue I, Takahashi A, Kubo M, Ooyama H, Shimizu T, Ichida K, Shinomiya N, Merriman TR, Matsuo H; Eurogout Consortium.
GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes.
Ann. Rheum. Dis., 76, 869-877, 2017.
Furukawa J, Inoue K, Ohta K, Yasujima T, Mimura Y, Yuasa H
Role of equilibrative nucleobase transporter 1/SLC43A3 as a ganciclovir transporter in the induction of cytotoxic effect of ganciclovir in a suicide gene therapy with herpes simplex virus thymidine kinase.
J. Pharmacol. Exp. Ther., 360, 59-68, 2017.
Yasujima T, Saito K, Moore R, Negishi M
Phenobarbital and Insulin Reciprocate Activation of the Nuclear Receptor Constitutive Androstane Receptor through the Insulin Receptor.
J. Pharmacol. Exp. Ther., 357, 367-374, 2016.
Furukawa J, Inoue K, Maeda J, Yasujima T, Ohta K, Kanai Y, Takada T, Matsuo H, Yuasa H
Functional identification of SLC43A3 as an equilibrative nucleobase transporter involved in purine salvage in mammals.
Sci. Rep., 5, 15057, 2015.
Mimura Y, Yasujima T, Ohta K, Inoue K, Yuasa H
Functional identification of organic cation transporter 1 as an atenolol transporter sensitive to flavonoids.
Biochem. Biophys. Rep., 2, 166-171, 2015.
Katano T, Ito Y, Ohta K, Yasujima T, Inoue K, Yuasa H
Competitive inhibition of AQP7-mediated glycerol transport by glycerol derivatives.
Drug Metab. Pharmacokinet., 29, 348-351, 2014.
Katano T, Ito Y, Ohta K, Yasujima T, Inoue K, Yuasa H
Functional characteristics of aquaporin 7 as a facilitative glycerol carrier.
Drug Metab. Pharmacokinet., 29, 244-248, 2014.
Yasujima T, Ohta K, Inoue K, Yuasa H
Characterization of human OCT1-mediated transport of DAPI as a fluorescent probe substrate.
J. Pharm. Sci., 100, 4006-4012, 2011.
Fujimura M, Yamamoto S, Murata T, Yasujima T, Inoue K, Ohta K, Yuasa H
Functional characteristics of the human ortholog of riboflavin transporter 2 and riboflavin-responsive expression of its rat ortholog in the small intestine indicate its involvement in riboflavin absorption.
J. Nutr., 140, 1722-1727, 2010.
Ohta KY, Inoue K, Yasujima T, Ishimaru M, Yuasa H
Functional characteristics of two human MATE transporters: kinetics of cimetidine transport and profiles of inhibition by various compounds.
J. Pharm. Pharm. Sci., 12, 388-396, 2009.
Yasujima T, Ohta KY, Inoue K, Ishimaru M, Yuasa H
Evaluation of 4',6-diamidino-2-phenylindole as a fluorescent probe substrate for rapid assays of the functionality of human multidrug and toxin extrusion proteins.
Drug Metab. Dispos., 38, 715-721, 2010.
Yamamoto S, Inoue K, Murata T, Kamigaso S, Yasujima T, Maeda J, Yoshida Y, Ohta K, Yuasa H
Identification and functional characterization of the first nucleobase transporters in mammals: implication in the species difference in the intestinal absorption mechanism of nucleobases and their analogs between higher primates and other mammals.
J. Biol. Chem., 285, 6522-6531, 2010.