Our research is aimed at understanding a basic cellular process, trafficking inside cells, in which proteins and membranes are shuttled between cellular organelles. This process is required for proper functioning of all cells, and therefore for every system of the human body. Elucidation of the mechanisms that regulate trafficking inside cells is relevant to a variety of diseases caused by impaired transport of substances that are either essential, such as insulin in diabetes, growth-factor receptors in cancer and CFTR in cystic fibrosis, or detrimental, such as β-amyloid in Alzheimer’s disease.
From Yeast to Human Cells and Disease:
Regulation and Coordination of Trafficking Inside Cells: secretion, endocytosis and autophagy
Neurological Disorders (neurodevelopmental and neurodegeneration)-associated mutations in highly conserved genes