Publications
Selected Publications
Establishing Regulation of a Dynamic Process by Ypt/Rab GTPases : A Case for Cisternal Progression.
Kim JJ, Lipatova Z, Segev N. Methods Mol Biol. 2021;2293:189-199. doi: 10.1007/978-1-0716-1346-7_13.
Characterization of constitutive ER-phagy of excess membrane proteins.
Lipatova Z, Gyurkovska V, Zhao SF, Segev N. PLoS Genet. 2020 Dec 4;16(12):e1009255. doi: 10.1371/journal.pgen.1009255. eCollection 2020 Dec.
TRAPPing a neurological disorder: from yeast to humans.
Lipatova Z, Van Bergen N, Stanga D, Sacher M, Christodoulou J, Segev N. Autophagy. 2020 May;16(5):965-966. doi: 10.1080/15548627.2020.1736873. Epub 2020 Mar 6.
Van Bergen NJ, Guo Y, Al-Deri N, Lipatova Z, Stanga D, Zhao S, Murtazina R, Gyurkovska V, Pehlivan D, Mitani T, Gezdirici A, Antony J, Collins F, Willis MJH, Coban Akdemir ZH, Liu P, Punetha J, Hunter JV, Jhangiani SN, Fatih JM, Rosenfeld JA, Posey JE, Gibbs RA, Karaca E, Massey S, Ranasinghe TG, Sleiman P, Troedson C, Lupski JR, Sacher M, Segev N, Hakonarson H, Christodoulou J. Brain. 2020 Jan 1;143(1):112-130. doi: 10.1093/brain/awz374.
Ypt/Rab GTPases and their TRAPP GEFs at the Golgi.
Lipatova Z, Segev N. FEBS Lett. 2019 Sep;593(17):2488-2500. doi: 10.1002/1873-3468.13574. Epub 2019 Aug 21.
Rab5-dependent autophagosome closure by ESCRT.
Zhou F, Wu Z, Zhao M, Murtazina R, Cai J, Zhang A, Li R, Sun D, Li W, Zhao L, Li Q, Zhu J, Cong X, Zhou Y, Xie Z, Gyurkovska V, Li L, Huang X, Xue Y, Chen L, Xu H, Xu H, Liang Y, Segev N. J Cell Biol. 2019 Jun 3;218(6):1908-1927. doi: 10.1083/jcb.201811173. Epub 2019 Apr 22.
A Rab5 GTPase module is important for autophagosome closure.
Zhou F, Zou S, Chen Y, Lipatova Z, Sun D, Zhu X, Li R, Wu Z, You W, Cong X, Zhou Y, Xie Z, Gyurkovska V, Liu Y, Li Q, Li W, Cheng J, Liang Y, Segev N. PLoS Genet. 2017 Sep 21;13(9):e1007020. doi: 10.1371/journal.pgen.1007020. eCollection 2017 Sep
Trs33-Containing TRAPP IV: A Novel Autophagy-Specific Ypt1 GEF.
Lipatova Z, Majumdar U, Segev N. Genetics. 2016 Nov;204(3):1117-1128. doi: 10.1534/genetics.116.194910. Epub 2016 Sep 26.
TRAPP Complexes in Secretion and Autophagy.
Kim JJ, Lipatova Z, Segev N. Front Cell Dev Biol. 2016 Mar 30;4:20. doi: 10.3389/fcell.2016.00020. eCollection 2016.
Regulation of Golgi Cisternal Progression by Ypt/Rab GTPases.
Kim JJ, Lipatova Z, Majumdar U, Segev N. Dev Cell. 2016 Feb 22;36(4):440-52. doi: 10.1016/j.devcel.2016.01.016.
A Role for Macro-ER-Phagy in ER Quality Control.
Lipatova Z, Segev N. PLoS Genet. 2015 Jul 16;11(7):e1005390. doi: 10.1371/journal.pgen.1005390. eCollection 2015 Jul.
Lipatova Z, Kim JJ, Segev N. Methods Mol Biol. 2015;1298:107-16. doi: 10.1007/978-1-4939-2569-8_9.
Ypt/Rab GTPases: principles learned from yeast.
Lipatova Z, Hain AU, Nazarko VY, Segev N. Crit Rev Biochem Mol Biol. 2015;50(3):203-11. doi: 10.3109/10409238.2015.1014023. Epub 2015
Ypt/Rab GTPases regulate two intersections of the secretory and the endosomal/lysosomal pathways.
Lipatova Z, Segev N. Cell Logist. 2014 Jul 3;4(3):e954870. doi: 10.4161/21592780.2014.954870. eCollection 2014 Jul-Sep.
A Vps21 endocytic module regulates autophagy.
Chen Y, Zhou F, Zou S, Yu S, Li S, Li D, Song J, Li H, He Z, Hu B, Björn LO, Lipatova Z, Liang Y, Xie Z, Segev N. Mol Biol Cell. 2014 Oct 15;25(20):3166-77. doi: 10.1091/mbc.E14-04-0917. Epub 2014 Aug 20.
Trs20 is required for TRAPP III complex assembly at the PAS and its function in autophagy.
Taussig D, Lipatova Z, Segev N. Traffic. 2014 Mar;15(3):327-37. doi: 10.1111/tra.12145. Epub 2014 Jan 14.
Regulation of ER-phagy by a Ypt/Rab GTPase module.
Lipatova Z, Shah AH, Kim JJ, Mulholland JW, Segev N. Mol Biol Cell. 2013 Oct;24(19):3133-44. doi: 10.1091/mbc.E13-05-0269. Epub 2013 Aug 7.
Trs20 is required for TRAPP II assembly.
Taussig D, Lipatova Z, Kim JJ, Zhang X, Segev N. Traffic. 2013 Jun;14(6):678-90. doi: 10.1111/tra.12065. Epub 2013 Mar 25.
A Ypt/Rab GTPase module makes a PAS.
Lipatova Z, Segev N. Autophagy. 2012 Aug;8(8):1271-2. doi: 10.4161/auto.20872. Epub 2012 Jun 6.
Regulation of selective autophagy onset by a Ypt/Rab GTPase module.
Lipatova Z, Belogortseva N, Zhang XQ, Kim J, Taussig D, Segev N. Proc Natl Acad Sci U S A. 2012 May 1;109(18):6981-6. doi: 10.1073/pnas.1121299109. Epub 2012 Apr 16.
Ypt31/32 GTPases and their F-Box effector Rcy1 regulate ubiquitination of recycling proteins.
Chen SH, Shah AH, Segev N. Cell Logist. 2011 Jan;1(1):21-31. doi: 10.4161/cl.1.1.14695.
GTPases in intracellular trafficking: an overview.
Segev N. Semin Cell Dev Biol. 2011 Feb;22(1):1-2. doi: 10.1016/j.semcdb.2010.12.004. Epub 2010 Dec 9.
Coordination of intracellular transport steps by GTPases.
Segev N. Semin Cell Dev Biol. 2011 Feb;22(1):33-8. doi: 10.1016/j.semcdb.2010.11.005. Epub 2010 Dec 2
TRAPP II complex assembly requires Trs33 or Trs65.
Tokarev AA, Taussig D, Sundaram G, Lipatova Z, Liang Y, Mulholland JW, Segev N. Traffic. 2009 Dec;10(12):1831-44. doi: 10.1111/j.1600-0854.2009.00988.x. Epub 2009 Sep 14
The TRAPP complex: insights into its architecture and function.
Sacher M, Kim YG, Lavie A, Oh BH, Segev N. Traffic. 2008 Dec;9(12):2032-42. doi: 10.1111/j.1600-0854.2008.00833.x. Epub 2008 Oct 14.
Lipatova Z, Tokarev AA, Jin Y, Mulholland J, Weisman LS, Segev N. Mol Biol Cell. 2008 Oct;19(10):4177-87. doi: 10.1091/mbc.e08-02-0220. Epub 2008 Jul 23.
Liang Y, Morozova N, Tokarev AA, Mulholland JW, Segev N. Mol Biol Cell. 2007 Jul;18(7):2533-41. doi: 10.1091/mbc.e07-03-0221. Epub 2007 May 2.
TRAPPII subunits are required for the specificity switch of a Ypt-Rab GEF.
Morozova N, Liang Y, Tokarev AA, Chen SH, Cox R, Andrejic J, Lipatova Z, Sciorra VA, Emr SD, Segev N. Nat Cell Biol. 2006 Nov;8(11):1263-9. doi: 10.1038/ncb1489. Epub 2006 Oct 15.
Ypt31/32 GTPases and their novel F-box effector protein Rcy1 regulate protein recycling.
Chen SH, Chen S, Tokarev AA, Liu F, Jedd G, Segev N. Mol Biol Cell. 2005 Jan;16(1):178-92. doi: 10.1091/mbc.e04-03-0258. Epub 2004 Nov 10
Ypt/rab gtpases: regulators of protein trafficking.
Segev N. Sci STKE. 2001 Sep 18;2001(100):re11. doi: 10.1126/stke.2001.100.re11.
Ypt and Rab GTPases: insight into functions through novel interactions.
Segev N. Curr Opin Cell Biol. 2001 Aug;13(4):500-11. doi: 10.1016/s0955-0674(00)00242-8.
The TRAPP complex is a nucleotide exchanger for Ypt1 and Ypt31/32.
Jones S, Newman C, Liu F, Segev N. Mol Biol Cell. 2000 Dec;11(12):4403-11. doi: 10.1091/mbc.11.12.4403.
Genetic interactions in yeast between Ypt GTPases and Arf guanine nucleotide exchangers.
Jones S, Jedd G, Kahn RA, Franzusoff A, Bartolini F, Segev N. Genetics. 1999 Aug;152(4):1543-56. doi: 10.1093/genetics/152.4.1543.
Identification of regulators for Ypt1 GTPase nucleotide cycling.
Jones S, Richardson CJ, Litt RJ, Segev N. Mol Biol Cell. 1998 Oct;9(10):2819-37. doi: 10.1091/mbc.9.10.2819.
GTP hydrolysis is not important for Ypt1 GTPase function in vesicular transport.
Richardson CJ, Jones S, Litt RJ, Segev N. Mol Cell Biol. 1998 Feb;18(2):827-38. doi: 10.1128/MCB.18.2.827.
Two new Ypt GTPases are required for exit from the yeast trans-Golgi compartment.
Jedd G, Mulholland J, Segev N. J Cell Biol. 1997 May 5;137(3):563-80. doi: 10.1083/jcb.137.3.563.
The Ypt1 GTPase is essential for the first two steps of the yeast secretory pathway.
Jedd G, Richardson C, Litt R, Segev N. J Cell Biol. 1995 Nov;131(3):583-90. doi: 10.1083/jcb.131.3.583.
Requirement of nucleotide exchange factor for Ypt1 GTPase mediated protein transport.
Jones S, Litt RJ, Richardson CJ, Segev N. J Cell Biol. 1995 Sep;130(5):1051-61. doi: 10.1083/jcb.130.5.1051.
Mediation of the attachment or fusion step in vesicular transport by the GTP-binding Ypt1 protein.
Segev N. Science. 1991 Jun 14;252(5012):1553-6. doi: 10.1126/science.1904626.
GTP-binding Ypt1 protein and Ca2+ function independently in a cell-free protein transport reaction.
Baker D, Wuestehube L, Schekman R, Botstein D, Segev N. Proc Natl Acad Sci U S A. 1990 Jan;87(1):355-9. doi: 10.1073/pnas.87.1.355.
Segev N, Mulholland J, Botstein D. Cell. 1988 Mar 25;52(6):915-24. doi: 10.1016/0092-8674(88)90433-3.
The ras-like yeast YPT1 gene is itself essential for growth, sporulation, and starvation response.
Segev N, Botstein D. Mol Cell Biol. 1987 Jul;7(7):2367-77. doi: 10.1128/mcb.7.7.2367-2377.1987.