NATPRO Journal

Accepted manuscript

HPLC Quantification and In Silico Analysis of Polyphenols from Moringa oleifera Targeting FPR2 in Epithelial Ovarian Cancer

NATPRO J (2026) 3: 9-16

https://doi.org/10.23177/NJ026.0404 

Authors: Chang-Dae Lee1 and Sanghyun Lee1,2*

Abstract: This study investigated the polyphenolic composition of Moringa oleifera and evaluated its potential biological relevance for epithelial ovarian cancer (EOC) using an integrated analytical and computational approach. High-performance liquid chromatography (HPLC) analysis revealed that (+)-catechin and quercetin 3-glucuronide were the major compounds, with concentrations of 32.12 mg/g and 19.14 mg/g, respectively. Network pharmacology and molecular docking were employed to predict the molecular targets and elucidate the pharmacological mechanisms of these compounds in the context of EOC. The results suggested that these compounds may interact with formyl peptide receptor 2 (FPR2), a key receptor highly implicated in EOC pathogenesis and inflammation-related signaling pathways. Both (+)-catechin and quercetin 3-glucuronide exhibited strong binding affinities to FPR2 in docking simulations, with scores of –8.7 and –10.7 kcal/mol, respectively, indicating possible involvement in modulating FPR2-related biological processes in EOC. These findings provide basic information on the polyphenolic profile of M. oleifera and suggest its potential as a source of bioactive compounds with potential applications to EOC-related biological processes. However, further experimental studies are required to validate these observations.

Received: April 6, 2026; Revised: April 30, 2026; Accepted: May 6, 2026; Published: May 7, 2026; E-mail: slee@cau.ac.kr

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