• Results:

The research activities planned for Stage 1 of the project allowed us to achieve all the proposed objectives:

- synthesis of anisotropic, stable, and biocompatible nanoparticles for the fabrication of theranostic agent

- characterization of synthesized anisotropic nanoparticles by spectroscopic, optical, and microscopic methods

- the most suitable nanoparticles for the intrinsic therapeutic component of the theranostic agent have been selected

- the selected anisotropic nanoparticles were loaded with DOX drug by two different methods to obtain the extrinsic chemotherapeutic component of the theranostic agent

- the DOX loading capacity of nanoparticles was evaluated to select the most efficient system as a theranostic agent for future studies

- the results obtained were disseminated in a scientific conference

- the project' web page was created and updated

The research activities planned for Stage 2 of the project allowed us to achieve all the proposed objectives:

- evaluation of drug release as a function of medium pH and temperature

- evaluation of heat generated upon theranostic anisotropic nanoparticles irradiation

- evaluation of drug release upon temperature rise after theranostic anisotropic nanoparticles irradiation

- evaluation of theranostic anisotropic nanoparticles in biological phantoms

- the results obtained were disseminated in a scientific paper and an oral presentation at an international conference

For additional information please find the resume of the project here