Design of hybrid nanoplatforms based on conjugated polymers and gold nanoparticles for plasmon-enhanced photodynamic therapy (PDT)
PN-III-P1-1.1-PD-2016-1898
Results
1st stage: Sept-Dec 2019
Water-soluble conjugated polymer nanoparticles (CP-NP) based on MEH-PPV were successfully prepared by the emulsification method using Pluronic
Optical and morphological characterization of CP-NP was performed (UV-Vis absorption spectroscopy, fluorescence spectroscopy, DLS measurements)
2nd stage: Jan-Dec 2020
Water-soluble conjugated polymer nanoparticles (CP-NP) based on PCPDTBT were successfully prepared by two methods: (i) emulsification using Pluronic and (ii) nanoprecipitation; the CP-NP were optically and morphologically characterized;
Spherical gold nanoparticles were conjugated with PCPDTBT polymer and stabilized by Pluronic; the obtained nano-conjugates were optically characterized;
Gold nanoparticle aggregates (GNA) were synthesized through a previously developed method and characterized; GNA were coupled with PCPDTBT polymer and the conjugates were characterized;
Gold nanoparticle aggregates were prepared through a newly developed method using PCPDTBT polymer; The obtained conjugates were stabilized with Pluronic and optically characterized;
Spectroscopic measurements were carried out (fluorescence, Raman) on GNA-PCPDTBT and CP-NP (in progress);