The main goal of this project is to rationally design an efficient and feasible photodynamic therapy (PDT) nano-platform, using conjugated polymers (CP) as photosensitizer and gold nanoparticles as nano-carriers and plasmon-mediated enhancers of the generation of cytotoxic agents, also allowing intracellular tracking by ultrasensitive spectroscopic methods. The proposed photodynamic nano-platform is schematically presented in the enclosed figure.