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The goal of this research is to develop a new technique for the detection of cancer in its early stage by taking advantage of recent advances in nano-technology and cancer-biomarker research. With cancer-specific molecular functionalization, our bio-transistor can selectively detect individual target cancer-derived molecules (e.g., exosome) and distinguish their subtype, both of which are not possible with the diagnostic tests available today.
The goal of this research is to develop a new technique for the detection of cancer in its early stage by taking advantage of recent advances in nano-technology and cancer-biomarker research. With cancer-specific molecular functionalization, our bio-transistor can selectively detect individual target cancer-derived molecules (e.g., exosome) and distinguish their subtype, both of which are not possible with the diagnostic tests available today.
Graphene Field Effect Biosensor
Graphene Field Effect Biosensor
AFM image of exosomes captured by the biosensors
AFM image of exosomes captured by the biosensors
Our plan is to validate the biosensor for a given clinical sample (i.e., blood) and integrate microfluidics to go beyond to the development of a prototype device for clinical tests. Our sensor will be able to reliably and precisely exosomes from benign and cancer patients, as well as integration of the sensors with microfluidics allow all-in-one separation, isolation, and detection of exosomes from unprocessed whole blood.
Our plan is to validate the biosensor for a given clinical sample (i.e., blood) and integrate microfluidics to go beyond to the development of a prototype device for clinical tests. Our sensor will be able to reliably and precisely exosomes from benign and cancer patients, as well as integration of the sensors with microfluidics allow all-in-one separation, isolation, and detection of exosomes from unprocessed whole blood.
Schematic diagram of the label-free, droplet, electronic exosome sensors which are fully integrated with the microfluidic system. All-in-one, three-stage process : plasma separation; exosome isolation; and exosome detection. Typical electronic detection signals with cancer exosomes (PANC1) and control exosomes (human serum).
Schematic diagram of the label-free, droplet, electronic exosome sensors which are fully integrated with the microfluidic system. All-in-one, three-stage process : plasma separation; exosome isolation; and exosome detection. Typical electronic detection signals with cancer exosomes (PANC1) and control exosomes (human serum).
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