Research Articles

61. A synthetic biomolecular condensate from plant proteins with controlled colloidal properties

 Pratyusha Ghosh, Nataliia Buhaichuka, Jenna Carr, Sakurako Tani, Raj Shankar Hazra, Sijo Mathew, Yongki Choi, Mohiuddin Quadir

Journal of Material Chemistry B, Advance Article, 2025 

60. Mechanistic underpinnings of epigenetic enzyme responsive nanoparticles

Raj Hazra, Debasmita Dutta, Rakib Khan, Sakurako Tani, Chowdhury Abdullah, Naznin Remex, Richa Aishwarya, Tamjid Islam, Zhongyu Yang, Sanku Mallik, Shenuarin Bhuiyan, Yongki Choi*, Mohiuddin Quadir*

ACS Applied Bio Materials, 8, 3845-3857, 2025 

59. Hypoxia-responsive polymersomes for stemness reduction in patient-derived solid tumor spheroids 

Connor Edvall, Narendra Kale, Sakurako Tani, Shubhashri Ambhore, Rayat Hossain, Chukwuebuka Ozoude, Karl Van Horsen, Jiyan Mohammad1 Daniel M. Tuvin, Santo Kalathingal, Jagadish Loganathan, Yongki Choi, Venkatachalem Sathish, James Brown, Sanku Mallik 

ACS Applied Bio Materials, 8, 2916-2926, 2025

58. Differential extracellular vesicle concentration and their biomarker expression of integrin αv/β5, EpCAM, and glypican-1 in pancreatic cancer models

Reed Jacobson, Sangdeuk Ha, Sakurako Tani, Shrinwanti Ghosh, Yagna P. R. Jarajapu, Randall E. Brand, Jiha Kim, Yongki Choi 

Scientific Report, 14, 14273, 2024

57. Colloidal 2D Layered SiC Quantum Dots from a Liquid Precursor: Surface Passivation, Bright Photoluminescence, and Planar Self-Assembly

Salim Thomas, Naif Alharthi, Reed Petersen, Ahmed Aldrees, Sakurako Tani, Kenneth Anderson, Joseph Granlie, Todd Pringle, Scott Payne, Yongki Choi, Dmitri Kilin, Erik Hobbie 

ACS Nano, 18, 26848-26857, 2024

56. Design and Evaluation of Nanoscale Materials with Programmed Responsivity towards Epigenetic Enzymes

Priyanka Ray,   Abbas Sedigh,   Matthew Confeld,   Lina Alhallahooly,   Kweeni Iduoku,   Gerardo Maikel Casañola Martin,   Hai Pham‑The,   Bakhtiyor Rasulev,   Yongki Choi,   Zhongyu Yang,   Sanku Mallik, Mohiuddin A. Quadir  

Journal of Materials Chemistry B, 12, 9905-9920, 2024 

55. Quadratic Fit Analysis of the Nonlinear Transconductance of Disordered Bilayer Graphene Field Effect Biosensors Functionalized with Pyrene Derivatives, in Graphene Field-Effect Transistors (Advanced Bioelectronic Devices for Sensing Application)

Sung Oh Woo, Sakurko Tani, Yongki Choi

Wiley-VCH, pp169-184, Aug 2023

54. Fabricating self-powered microfluidic devices via 3D printing for manipulating fluid flow

Sung Oh Woo, Myungkeun Oh, Yongki Choi

STAR Protocols, 3, 101376, 2022

53. Acquired aSMA expression in pericytes coincides with aberrant vascular structure and function in Pancreatic Ductal Adenocarcinoma  

Vikneshwari Natarajan, Sangdeuk Ha, Alexander Delgado, Reed Jacobson, Lina Alhalhooly, Yongki Choi, Jiha Kim 

Cancers, 14, 2448, 2022

52. Single Molecule Force Probing of RGD-binding Integrins on Pancreatic Cancer Cells  

Lina Alhalhooly, Matthew Confeld, Sung Oh Woo, Babak Mamnoon, Reed Jacobson, Shrinwanti Ghosh, Jiha Kim, Sanku Mallik, Yongki Choi

ACS Applied Materials & Interfaces, 14, 7671-7679, 2022

51. Modified Bovine Milk Exosomes for Doxorubicin Delivery to Triple-Negative Breast Cancer Cells

Jessica Pullan, Kaitlin Dailey, Sangeeta Bhallamudi, Li Feng, Lina Alhalhooly, Jamie Froberg, Jenna Osborn, Kausik Sarkar, Todd Molden, Venkatachalem Sathish, Yongki Choi, Amanda Brooks, Sanku Mallik

ACS Applied Bio Materials, 5, 2163-2175, 2022

50. Dynamic cellular biomechanics in responses to chemotherapeutic drug in hypoxia probed by atomic force spectroscopy  

Lina Alhalhooly, Babak Mamnoon, Jiha Kim,  Sanku Mallik, Yongki Choi   

Oncotarget, 12, 1165-1177, 2021

49. Different single-enzyme conformational dynamics upon binding hydrolyzable or nonhydrolyzable ligands   

Sung Oh Woo, Myungkeun Oh, Lina Alhalhooly, Jasmin Farmakes, Arith Rajapakse, Zhongyu Yang, Philip G. Collins, Yongki Choi  

The Journal of Physical Chemistry B, 125, 5750-5756, 2021, Featured on the journal cover!

48. Targeting estrogen receptor-positive breast microtumors with endoxifen-conjugated, hypoxia-sensitive polymersomes

Babak Mamnoon, Li Feng, James Froberg, Yongki Choi, Venkatachalem Sathish, Oleh Taratula, Olena Taratula, and Sanku Mallik

ACS Omega, 6, 42, 27654-27667, 2021

47. Molecular diffusion analysis of dynamic blood flow and plasma separation driven by self-powered microfluidic devices  

Sung Oh Woo, Myungkeun Oh, Kyle Nietfeld, Bailey Boehler, Yongki Choi  

Biomicrofluidics, 15, 034106, 2021

46. Targeted polymer nanoparticles for drug delivery to hypoxic, triple-negative breast tumors 

Babak Mamnoon; Jagadish Loganathan; Matthew I Confeld; Nimesha De Fonseka; Li Feng; James Froberg; Yongki Choi; Daniel M Tuvin; Venkatachalem Sathish, Sanku Mallik  

ACS Applied Bio Materials, 4, 1450-1460, 2021

45. Hypoxia-responsive, polymeric nanocarriers for targeted drug delivery to estrogen receptor-positive breast cancer cell spheroids

Babak Mamnoon,  Li Feng, Jamie Froberg, Yongki Choi, Venkatachalem Sathish, Sanku Mallik

Molecular Pharmaceutics, 17, 4312-4322, 2020

44. Size-tunable Metal-Organic Framework Coated Magnetic Nanoparticles for Enzyme Encapsulation and Large-Substrate Biocatalysis

Qiaobin Li, Yanxiong Pan, Hui Li, Lina Alhalhooly, Yue Li, Bingcan Chen, Yongki Choi, Zhongyu Yang

ACS Applied Materials and Interfaces, 12, 41794-41801, 2020

43. Targeting the tumor core: hypoxia-responsive nanoparticles for delivery of chemotherapy to pancreatic tumors

M. Confeld, B. Mamnoon, L. Feng, H. Jensen, P. Roy, J. Froberg, J. Kim, M. Hollingsworth, M. Quadir, Y. Choi , S. Mallik

Molecular Pharmaceutics,  17, 2849-2863, 2020

42. Protein Detection Using Quadratic Fit Analysis near the Dirac Point of Graphene Field-Effect Biosensors

Sung Oh Woo, James Froberg, Yanxiong Pan, Sakurako Tani, Brett R. Goldsmith, Zhongyu Yang, and Yongki Choi

ACS Applied Electronic Materials,  2, 913-919, 2020

41. Echogenic exosomes as ultrasound contrast agents 

J. Osborn, J. Pullan, J. Froberg, J. Shreffler, K. Gange, T. Molden, Y. Choi,  A. Brooks, S. Mallik, K. Sarkar 

Nanoscale Advances,  2, 3411-3422, 2020

40. Enzyme Immobilization on Graphite Oxide (GO) Surface via One-Pot Synthesis of GO/Metal–Organic Framework Composites for Large-Substrate Biocatalysis

Jasmin Farmakes, Isabelle Schuster, Amanda Overby, Lina Alhalhooly, Mary Lenertz, Qiaobin Li, Angel Ugrinov, Yongki Choi, Yanxiong Pan, and Zhongyu Yang

ACS Applied Materials and Interfaces,  12, 20, 23119-23126, 2020

39. Selective Manipulation of Biomolecules with Insulator-Based Dielectrophoretic Tweezers

Myungkeun Oh, Vidura Jayasooriya, Sung Oh Woo, Dharmakeerthi Nawarathna, and Yongki Choi

ACS Applied Nano Materials,  3, 797-805, 2020

38. Size-Transformable, Multifunctional Nanoparticles from Hyperbranched Polymers for Environment-Specific Therapeutic Delivery

P. Ray, L. Alhalhooly, A. Ghosh, Y. Choi , S. Banerjee, S. Mallik, S. Banerjee, M. Quadir

ACS Biomaterials Sci. Eng., 5, 1354-1365, 2019 

37. Electronic Structure and Properties of Lithium-Rich Complex Oxides

K. Hoang, M. Oh, Y. Choi 

ACS Applied Electronic Materials,  1, 75-81, 2019 

36. Real-time tracking of single-molecule collagenase on native collagen and partially structured collagen-mimic substrates

J. Froberg, W. Choi, A. Sedigh, T. Anajafi, J. Farmakes, Z. Yang, S. Mallik, D. Srivastava, Y. Choi

Chemical Communications, 54, 10248-10251, 2018, Featured on the journal back cover 

35. Nucleus-Targeted, Echogenic Polymersomes for Delivering a Cancer Stemness Inhibitor to Pancreatic Cancer Cells

F. Karandish, B. Mamnoon, L. Feng, M. Haldar, L. Xia, K. Gange, S. You, Y. Choi , K. Sarkar, S. Mallik

Biomacromolecules, 19, 4122-4132, 2018 

34. Insights on the structure, molecular weight, and activity of an antibacterial protein-polymer hybrid

Y. Pan, S. Neupane, J. Farmakes, M. Oh, K. Bentz, Y. Choi*, Z. Yang*

ChemPhysChem, 19, 651-658, 2018 

33. Electronic structure and polaron formation in transition-metal tungstates

K. Hoang, M. Oh, Y. Choi

RSC Advances, 8, 4191-4196, 2018 

32. Atomic Force Microscopy in Dielectrophoresis Applications in Atomic Force Microscopy: Principles, Developments and Applications

J. Froberg, M. Oh, V. Jayasooriya, D. Nawarathna, Y. Choi 

Nova Publishers, 21-46, 2018

31. Peptide-targeted, stimuli-responsive polymersomes for delivering a cancer stemness inhibitor to cancer stem cell microtumors

F. Karandish, J. Froberg, P. Borowics, J. Wilkinson, Y. Choi , S. Mallik

Collois and Surfaces B: Biointerface, 163, 225-235,2018 

30. Acoustic characterization of echogenic polymersomes prepared from amphiphilic block copolymers

L. Xia, F. Karandish, K. Kumar, J. Froberg, P. Kulkarni, K. Gange, Y. Choi , S. Mallik, K. Sarkar

Ultrasound in Medicine and Biology, 44, 447-457,2018 

29. Quantitative measurements of dielectrophoresis in a nanoscale electrode array with an atomic force microscopy

J. Froberg, V. Jayasooriya, S. You, D. Nawarathna, Y. Choi

Applied Physics Letters, 110, 203701, 2017 

28. Real-time monitoring of conformational transitions of single-molecule histone deacetylase 8 with nanocircuits

S. You, J. Froberg, J. Yu, M. Haldar, A. Sedigh, S. Mallik, D. Srivastava, Y. Choi

Chemical Communications, 53, 3307-3310, 2017

Featured on the journal back cover 

27. Probing the structural basis and adsorption mechanism of an enzyme on nano-sized protein carriers

Y. Pan, S. Neupane, J. Farmakes, M. Bridges, J. Froberg, J. Rao, S. Qian, G. Liu, Y. Choi, Z. Yang

Nanoscale, 9, 3512-3523, 2017 

26. Nuclear Localizing Peptide Conjugated, Redox Sensitive Polymersomes for Delivering Curcumin and Doxorubicin to Pancreatic Cancer Micro-tumors

T. Anajafi, J. Yu, A. Sedigh, M. Haldar, W. Muhonen, S. Oberlander, H. Wasness, J. Froberg, S. Molla, K. Katti, Y. Choi, J. Shabb, D. Srivastava, S. Mallik

Molecular Pharmaceutics, 14, 1916-1928, 2017 

25. Prostate-specific membrane antigen targeted polymersomes for delivering mocetinostat and docetaxel to prostate cancer cell spheroids

F. Fataneh, M. Haldar, S. You, A. Brooks, B. Brooks, B. Guo, Y. Choi , S. Mallik

ACS Omega, 1, 952-962, 2016 

24. Hypoxia-responsive, tumor penetrating lipid nanoparticles for delivery of chemotherapeutics to pancreatic cancer cell spheroids

P. Kulkarni, M. Haldar, P. Katti, C. Dawes, S. You, Y. Choi , S. Mallik

Bioconjugate Chemistry, 27, 1830-1838, 2016 

23. Hypoxia-responsive polymersomes for drug delivery to hypoxic pancreatic cancer cells

P. Kulkarni, M. Haldar, S. You, Y. Choi , S. Mallik

Biomacromolecules, 17, 2507-2513, 2016 

22. Single Molecule Bioelectronics and Their Application to Amplification-Free Measurement of DNA Lengths

O. Gul*, K. Pugliese*, Y. Choi* , P. Sims, D. Pan, A. Rajapakes, G. Weiss, P. Collins

Biosensors, 6, 29, 2016 

21. Acridine orange Conjugated Polymersomes for Simultaneous Nuclear Delivery of Gemcitabine and Doxorubicin to Pancreatic Cancer Cells

T. Anajafi, M. Scott, S. You, X. Yang, Y. Choi , S. Qian, and S. Mallik

Bioconjugate Chemistry, 27, 762-771, 2016 

20. Processive Incorporation of Deoxynucleoside Triphosphate Analogs by Single-Molecule DNA Polymerase I (Knenow Fragment) Nancircuits

K. Pugliese, O. Gul, Y. Choi, T. Olsen, P. Collins, G. Weiss

Journal of the American Chemical Society, 137, 9587-9594, 2015 

19. Observing Lysozyme's Closing and Opening Motions by High-Resolution Single Molecule Enzymology

M. Akhterov, Y. Choi, T. Olsen, P. Sims, M. Iftikhar, O. Gul, B. Corso, G. Weiss, P. Collins

ACS Chemical Biology, 10, 1495-1501, 2015 

18. Single Molecule Bioelectronics in Handbook of Bioelectronics, Cambridge University Press, 66-85, 2015

Y. Choi, G. Weiss, and P. Collins 

17. Single Molecule Recordings of Lysozyme Activity

Y. Choi, G. Weiss, and P. Collins

Physical Chemistry Chemical Physics, 15, 14879-14895, 2013

Featured on the journal cover 

16. Single Molecule Sensing with Carbon Nanotube Devices

Y. Choi, P. Sims, T. Olsen, M. Iftikhar, B. Corso, O. Gul, G. Weiss, and P. Collins

Proc. SPIE, 8814, 8814Q, 2013 

15. Single Molecule Enzymology Using Carbon Nanotube Circuits

Y. Choi, P. Sims, T. Olsen, O. Gul, B. Corso, M. Iftikhar, G. Weiss, and P. Collins

IEEE Transducers, 17, 633-636, 2013 

14. Electronic Measurement of Single-Molecule Processing by DNA polymerase I (Knenow Fragment)

T. Olsen*, Y. Choi*, O. Gul, B. Corso, C. Dong, W. Brown, P. Collins, and G. Weiss

Journal of the American Chemical Society, 135, 7855-7860, 2013 

13. Electronic Measurement of the Single-Molecule Catalysis by cAMP-Dependent Protein Kinase A

P. Sims, I. Moody, Y. Choi, B. Corso, O. Gul, M. Iftikhar, P. Collins, and G. Weiss

Journal of the American Chemical Society, 135, 7861-7868, 2013 

12. “Dissecting Lysozyme by Single-Molecule Techniques” in Lysozymes, Sources, Functions and Role in Disease, Nova Publishers, 193-214, 2013

I. Moody, Y. Choi, T. Olsen, P. Sims, P. Collins, and G. Weiss

11. Dissecting Single-Molecule Signal Transduction by Carbon Nanotube Circuits with Protein Engineering

Y. Choi*, T. Olsen*, P. Sims, I. Moody, B. Corso, T. Dang, G. Weiss, and P. Collins

Nano Letters, 13, 625-631, 2013 

10. Single-Molecule Dynamics of Lysozyme Processing Distinguishes Linear and Cross-Linked Peptidoglycan Substrates

Y. Choi, I. Moody, P. Sims, S. Hunt, B. Corso, P. Collins, and G. Weiss,

Journal of the American Chemical Society, 134, 2032-2035, 2012

Highlighted in Nature Methods, 9, 226, 2012 “Single-molecule circuits”

JACS Select Collection “the Chemistry-glycobiology frontier” 

9. Single Molecule Lysozyme Dynamics Monitored by an Electronic Circuit

Y. Choi*, I. Moody*, P. Sims, S. Hunt, B. Corso, I. Perez, G. Weiss, and P. Collins,

Science, 335, 319-324, 2012

Highlighted in Science, 335, 300, 2012 “Enzyme in Coherent Motion”

Nature Methods, 9, 226, 2012 “Single-molecule circuits”

Nature Rev. Mol. Cell Bio., 13, 138, 2012 “Technique: Lysozyme get wired”

Chem. & Engineer. News, 90, 28, 2012, “Nanotube detects enzyme motion”

LA Times, Fox News, Popular Science, National Public Radio, Voice of America, etc

8. Field-Controlled Electron Transfer and Reaction Kinetics of the Biological Catalytic System of Microperoxidase-11 and Hydrogen Peroxide

Y. Choi and S.-T. Yau,

AIP Advances, 1, 042175, 2011 

7. Ultrasensitive biosensing on the zepto-molar level

Y. Choi and S.-T. Yau,

Biosensors and Bioelectronics, 26, 3386-3390, 2011 

6. Field-effect enzymatic amplifying detector with pico-molar detection limit

Y. Choi and S.-T. Yau,

Analytical Chemistry, 81, 7123-7126, 2009 

5. A hybrid biofuel cell based on electrocatalysis of glucose using ultra-small silicon nanoparticles

Y. Choi, M.H. Nayfeh, and S.-T. Yau,

Biosensors and Bioelectronics, 24, 3103-3107, 2009 

4. Electro-oxidation of organic fuels catalyzed by ultrasmall silicon nanoparticles

Y. Choi, G. Wang, M. H. Nayfeh, and S.-T. Yau,

Applied Physics Letters, 93, 164103, 200 

3. An electronic composite of sulfonated tetrafluorethylene copolymer with potassium ferricyanide exhibiting room-temperature negative differential resistance

Y. Choi, G. Wang, and S.-T. Yau,

Applied Physics Letters, 89, 233116, 2006 

2. Two-dimensional crystal of several millimeter size spheres

Y. Choi, K. Kim, and H. K. Pak,

Physica A, 281, 99-104, 2000 

1. Two Dimensional System of Several Millimeter Size Spheres Using Triboelectrification

Y. Choi, K. Kim, and H. K. Pak,

Journal of the Korean Physical Society, 35, S1155-S1158, 1999