Regenerative Medicine

Regenerative medicine holds the promise of revolutionizing healthcare by harnessing the body's innate capacity for repair and regeneration to treat a wide range of diseases and injuries. By leveraging advances in stem cell biology, tissue engineering, biomaterials, and gene therapy, regenerative medicine offers novel approaches for addressing unmet medical needs, particularly in areas such as degenerative diseases. Through the integration of nanotechnology with biology and engineering principles, nanobioengineering also offers unique  opportunities to precisely control cellular behavior, deliver therapeutic agents, and create biomimetic scaffolds that mimic the native tissue microenvironment.

Representative research publications in this area

• Jung, M., Kim, H., Hwang, J.W., Choi, Y., Kang, M., Kim, C., Hong, J., Lee, N.K., Moon, S., Chang, J.W. and Choi, S.J., 2023. Iron oxide nanoparticle-incorporated mesenchymal stem cells for Alzheimer’s disease treatment. Nano Letters, 23(2), pp.476-490. https://pubs.acs.org/doi/full/10.1021/acs.nanolett.2c03682 

• Jung, M., Lee, S., Park, S., Hong, J., Kim, C., Cho, I., Sohn, H.S., Kim, K., Park, I.W., Yoon, S. and Kwon, S., 2023. A Therapeutic Nanovaccine that Generates Anti‐Amyloid Antibodies and Amyloid‐specific Regulatory T Cells for Alzheimer's Disease. Advanced Materials, 35(3), p.2207719. https://onlinelibrary.wiley.com/doi/full/10.1002/adma.202207719 

• Lim, S., An, S.B., Jung, M., Joshi, H.P., Kumar, H., Kim, C., Song, S.Y., Lee, J.R., Kang, M., Han, I. and Kim, B.S., 2022. Local delivery of senolytic drug inhibits intervertebral disc degeneration and restores intervertebral disc structure. Advanced healthcare materials, 11(2), p.2101483. https://onlinelibrary.wiley.com/doi/full/10.1002/adhm.202101483 

• Lee, J.R., Park, B.W., Kim, J., Choo, Y.W., Kim, H.Y., Yoon, J.K., Kim, H., Hwang, J.W., Kang, M., Kwon, S.P. and Song, S.Y., 2020. Nanovesicles derived from iron oxide nanoparticles–incorporated mesenchymal stem cells for cardiac repair. Science advances, 6(18), p.eaaz0952. https://www.science.org/doi/full/10.1126/sciadv.aaz0952